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Hyperhomocysteinemia and related genetic polymorphisms correlate with ulcerative colitis in Chinese Han population in Central China [corrected].
Cell Biochem Biophys 2012; 62(1):203-10CB

Abstract

Increased levels of homocysteine are found systemically and in intestinal mucosa of patients with inflammatory bowel disease, and, specifically, in ulcerative colitis (UC). However, there are controversial reports regarding the factors contributing to increased levels of homocysteine in UC. Furthermore, little information is available regarding the relationship between hyperhomocysteinemia (HHcy), vitamin status, and genetic polymorphisms of homocysteine-related enzymes in these patients. This study examined four functional polymorphisms linked to homocysteine metabolism (MTHFR C677T and A1298C, MTR A2756G and MTRR A66G), and evaluated plasma levels of homocysteine, folate, and vitamin B(12) in 310 consecutive patients with UC and 936 age- and sex-matched healthy controls from southeast China. The variant allele and genotypic frequencies in MTHFR A1298C, MTR A2756G and MTRR A66G genes were significantly higher in patients with UC compared to healthy controls. Further, HHcy and low levels of folate and vitamin B(12) were more frequent in patients with UC. The MTR 2756G allele, extent of the disease, and gender were the independent determinants of HHcy in these patients. These findings suggest that genetic and nutritional factors have a synergetic effect on HHcy in patients with UC. In conclusion, our data highlight a prevention strategy for moderation of HHcy and supplementation with folate and vitamine B(12) in patients with UC from Southeast China.

Authors+Show Affiliations

Department of Gastroenterology, Second Affiliated Hospital of Wenzhou Medical College, Wenzhou, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21947961

Citation

Jiang, Yi, et al. "Hyperhomocysteinemia and Related Genetic Polymorphisms Correlate With Ulcerative Colitis in Chinese Han Population in Central China [corrected]." Cell Biochemistry and Biophysics, vol. 62, no. 1, 2012, pp. 203-10.
Jiang Y, Xia X, Wang W, et al. Hyperhomocysteinemia and related genetic polymorphisms correlate with ulcerative colitis in Chinese Han population in Central China [corrected]. Cell Biochem Biophys. 2012;62(1):203-10.
Jiang, Y., Xia, X., Wang, W., Lin, L., Xu, C., Cai, Z., ... Xia, B. (2012). Hyperhomocysteinemia and related genetic polymorphisms correlate with ulcerative colitis in Chinese Han population in Central China [corrected]. Cell Biochemistry and Biophysics, 62(1), pp. 203-10. doi:10.1007/s12013-011-9283-4.
Jiang Y, et al. Hyperhomocysteinemia and Related Genetic Polymorphisms Correlate With Ulcerative Colitis in Chinese Han Population in Central China [corrected]. Cell Biochem Biophys. 2012;62(1):203-10. PubMed PMID: 21947961.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hyperhomocysteinemia and related genetic polymorphisms correlate with ulcerative colitis in Chinese Han population in Central China [corrected]. AU - Jiang,Yi, AU - Xia,Xuanping, AU - Wang,Wenxing, AU - Lin,Limiao, AU - Xu,Changlong, AU - Cai,Zhenzai, AU - Zheng,Bo, AU - Pei,Jihua, AU - Shen,Sujian, AU - Xia,Bing, PY - 2011/9/28/entrez PY - 2011/9/29/pubmed PY - 2012/5/5/medline SP - 203 EP - 10 JF - Cell biochemistry and biophysics JO - Cell Biochem. Biophys. VL - 62 IS - 1 N2 - Increased levels of homocysteine are found systemically and in intestinal mucosa of patients with inflammatory bowel disease, and, specifically, in ulcerative colitis (UC). However, there are controversial reports regarding the factors contributing to increased levels of homocysteine in UC. Furthermore, little information is available regarding the relationship between hyperhomocysteinemia (HHcy), vitamin status, and genetic polymorphisms of homocysteine-related enzymes in these patients. This study examined four functional polymorphisms linked to homocysteine metabolism (MTHFR C677T and A1298C, MTR A2756G and MTRR A66G), and evaluated plasma levels of homocysteine, folate, and vitamin B(12) in 310 consecutive patients with UC and 936 age- and sex-matched healthy controls from southeast China. The variant allele and genotypic frequencies in MTHFR A1298C, MTR A2756G and MTRR A66G genes were significantly higher in patients with UC compared to healthy controls. Further, HHcy and low levels of folate and vitamin B(12) were more frequent in patients with UC. The MTR 2756G allele, extent of the disease, and gender were the independent determinants of HHcy in these patients. These findings suggest that genetic and nutritional factors have a synergetic effect on HHcy in patients with UC. In conclusion, our data highlight a prevention strategy for moderation of HHcy and supplementation with folate and vitamine B(12) in patients with UC from Southeast China. SN - 1559-0283 UR - https://www.unboundmedicine.com/medline/citation/21947961/Hyperhomocysteinemia_and_related_genetic_polymorphisms_correlate_with_ulcerative_colitis_in_Chinese_Han_population_in_Central_China_[corrected]_ L2 - https://dx.doi.org/10.1007/s12013-011-9283-4 DB - PRIME DP - Unbound Medicine ER -