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Elevated levels of oxidized low-density lipoprotein correlate positively with C-reactive protein in patients with acute coronary syndrome.
Cell Biochem Biophys 2012; 62(2):365-72CB

Abstract

The relationship between oxidized low-density lipoprotein (Ox-LDL) and C-reactive protein (CRP) in patients with acute coronary syndrome (ACS) is unknown. We, therefore, measured serum levels of Ox-LDL and high-sensitivity (hs)-CRP in 90 ACS patients, 45 stable angina pectoris (SAP) patients, and 66 healthy controls using sandwich ELISA. ACS patients were subdivided into: (1) acute myocardial infarction (AMI; n = 45); (2) unstable angina pectoris (UAP; n = 45) groups. In AMI patients, Ox-LDL (177.5 mmol/l) and hs-CRP (25.40 mg/l) levels were significantly higher (P < 0.01) than in UAP (Ox-LDL:107.5 mmol/l, hs-CRP:10.7 mg/l) and SAP (Ox-LDL:82.3 mmol/l, hs-CRP:2.10 mg/l) patients as well as controls (Ox-LDL:41.4 mmol/l, hs-CRP:1.76 mg/l). Ox-LDL/hs-CRP levels in UAP patients were significantly higher (P < 0.01) than in SAP patients and controls. Importantly, a positive correlation was found between Ox-LDL and CRP (r = 0.622; P < 0.01) levels. Serum levels of total, HDL, and LDL cholesterol did not differ among these patient groups. In conclusion, our data show that Ox-LDL and hs-CRP levels correlate positively in ACS patients, supporting the hypothesis that Ox-LDL and CRP may play a direct role in promoting the inflammatory component of atherosclerosis in these individuals. We suggest that Ox-LDL/CRP elevated levels may serve as markers of the severity of the disease in evaluation and management of ACS patients.

Authors+Show Affiliations

Division of Cardiology, Xinhua Hospital School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China. zhangyachen65@yahoo.com.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21947962

Citation

Zhang, Ya-chen, et al. "Elevated Levels of Oxidized Low-density Lipoprotein Correlate Positively With C-reactive Protein in Patients With Acute Coronary Syndrome." Cell Biochemistry and Biophysics, vol. 62, no. 2, 2012, pp. 365-72.
Zhang YC, Wei JJ, Wang F, et al. Elevated levels of oxidized low-density lipoprotein correlate positively with C-reactive protein in patients with acute coronary syndrome. Cell Biochem Biophys. 2012;62(2):365-72.
Zhang, Y. C., Wei, J. J., Wang, F., Chen, M. T., & Zhang, M. Z. (2012). Elevated levels of oxidized low-density lipoprotein correlate positively with C-reactive protein in patients with acute coronary syndrome. Cell Biochemistry and Biophysics, 62(2), pp. 365-72. doi:10.1007/s12013-011-9295-0.
Zhang YC, et al. Elevated Levels of Oxidized Low-density Lipoprotein Correlate Positively With C-reactive Protein in Patients With Acute Coronary Syndrome. Cell Biochem Biophys. 2012;62(2):365-72. PubMed PMID: 21947962.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Elevated levels of oxidized low-density lipoprotein correlate positively with C-reactive protein in patients with acute coronary syndrome. AU - Zhang,Ya-chen, AU - Wei,Jing-jing, AU - Wang,Fei, AU - Chen,Man-tian, AU - Zhang,Mao-zhen, PY - 2011/9/28/entrez PY - 2011/9/29/pubmed PY - 2012/6/13/medline SP - 365 EP - 72 JF - Cell biochemistry and biophysics JO - Cell Biochem. Biophys. VL - 62 IS - 2 N2 - The relationship between oxidized low-density lipoprotein (Ox-LDL) and C-reactive protein (CRP) in patients with acute coronary syndrome (ACS) is unknown. We, therefore, measured serum levels of Ox-LDL and high-sensitivity (hs)-CRP in 90 ACS patients, 45 stable angina pectoris (SAP) patients, and 66 healthy controls using sandwich ELISA. ACS patients were subdivided into: (1) acute myocardial infarction (AMI; n = 45); (2) unstable angina pectoris (UAP; n = 45) groups. In AMI patients, Ox-LDL (177.5 mmol/l) and hs-CRP (25.40 mg/l) levels were significantly higher (P < 0.01) than in UAP (Ox-LDL:107.5 mmol/l, hs-CRP:10.7 mg/l) and SAP (Ox-LDL:82.3 mmol/l, hs-CRP:2.10 mg/l) patients as well as controls (Ox-LDL:41.4 mmol/l, hs-CRP:1.76 mg/l). Ox-LDL/hs-CRP levels in UAP patients were significantly higher (P < 0.01) than in SAP patients and controls. Importantly, a positive correlation was found between Ox-LDL and CRP (r = 0.622; P < 0.01) levels. Serum levels of total, HDL, and LDL cholesterol did not differ among these patient groups. In conclusion, our data show that Ox-LDL and hs-CRP levels correlate positively in ACS patients, supporting the hypothesis that Ox-LDL and CRP may play a direct role in promoting the inflammatory component of atherosclerosis in these individuals. We suggest that Ox-LDL/CRP elevated levels may serve as markers of the severity of the disease in evaluation and management of ACS patients. SN - 1559-0283 UR - https://www.unboundmedicine.com/medline/citation/21947962/Elevated_levels_of_oxidized_low_density_lipoprotein_correlate_positively_with_C_reactive_protein_in_patients_with_acute_coronary_syndrome_ L2 - https://dx.doi.org/10.1007/s12013-011-9295-0 DB - PRIME DP - Unbound Medicine ER -