Tags

Type your tag names separated by a space and hit enter

The structure and function of the macula in patients with advanced retinitis pigmentosa.
Invest Ophthalmol Vis Sci. 2011 Oct 28; 52(11):8425-32.IO

Abstract

PURPOSE

To assess the structure and function of the macula in advanced retinitis pigmentosa (RP).

METHODS

Twenty-nine eyes of 22 patients with RP were compared against 17 control eyes. Time-domain optical coherence tomography (OCT) data were processed using OCTRIMA (optical coherence tomography retinal image analysis) as a means of quantifying commercial OCT system images. The thickness of the retinal nerve fiber layer (RNFL), ganglion cell layer and inner plexiform layer complex (GCL+IPL), inner nuclear layer and outer plexiform layer complex (INL+OPL), and the outer nuclear layer (ONL) were measured. Multifocal electroretinography (mfERG) was performed; two groups were formed based on the mfERG findings. Fourteen eyes had no detectable central retinal function (NCRF) on mfERG; detectable but abnormal retinal function (DRF) was present in the mfERG of the other 15 eyes.

RESULTS

The thickness of the ONL in the central macular region was significantly less in the NCRF eyes compared with that in both DRF eyes and controls. The ONL was significantly thinner in the pericentral region in both patient groups compared with that in controls, whereas the thickness of the GCL+IPL and INL+OPL was significantly decreased only in the NCRF eyes. The RNFL in the peripheral region was significantly thicker, whereas the thickness of the GCL+IPL and ONL was significantly thinner in both patient groups compared with that in controls.

CONCLUSIONS

The results are consistent with degeneration of the outer retina preceding inner retinal changes in RP. OCT image segmentation enables objective evaluation of retinal structural changes in RP, with potential use in the planning of therapeutic interventions and conceivably as an outcome measure.

Authors+Show Affiliations

Department of Ophthalmology, Semmelweis University, Budapest, Hungary.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21948552

Citation

Vámos, Rita, et al. "The Structure and Function of the Macula in Patients With Advanced Retinitis Pigmentosa." Investigative Ophthalmology & Visual Science, vol. 52, no. 11, 2011, pp. 8425-32.
Vámos R, Tátrai E, Németh J, et al. The structure and function of the macula in patients with advanced retinitis pigmentosa. Invest Ophthalmol Vis Sci. 2011;52(11):8425-32.
Vámos, R., Tátrai, E., Németh, J., Holder, G. E., DeBuc, D. C., & Somfai, G. M. (2011). The structure and function of the macula in patients with advanced retinitis pigmentosa. Investigative Ophthalmology & Visual Science, 52(11), 8425-32. https://doi.org/10.1167/iovs.11-7780
Vámos R, et al. The Structure and Function of the Macula in Patients With Advanced Retinitis Pigmentosa. Invest Ophthalmol Vis Sci. 2011 Oct 28;52(11):8425-32. PubMed PMID: 21948552.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The structure and function of the macula in patients with advanced retinitis pigmentosa. AU - Vámos,Rita, AU - Tátrai,Erika, AU - Németh,János, AU - Holder,Graham E, AU - DeBuc,Delia Cabrera, AU - Somfai,Gábor Márk, Y1 - 2011/10/28/ PY - 2011/9/28/entrez PY - 2011/9/29/pubmed PY - 2012/1/5/medline SP - 8425 EP - 32 JF - Investigative ophthalmology & visual science JO - Invest Ophthalmol Vis Sci VL - 52 IS - 11 N2 - PURPOSE: To assess the structure and function of the macula in advanced retinitis pigmentosa (RP). METHODS: Twenty-nine eyes of 22 patients with RP were compared against 17 control eyes. Time-domain optical coherence tomography (OCT) data were processed using OCTRIMA (optical coherence tomography retinal image analysis) as a means of quantifying commercial OCT system images. The thickness of the retinal nerve fiber layer (RNFL), ganglion cell layer and inner plexiform layer complex (GCL+IPL), inner nuclear layer and outer plexiform layer complex (INL+OPL), and the outer nuclear layer (ONL) were measured. Multifocal electroretinography (mfERG) was performed; two groups were formed based on the mfERG findings. Fourteen eyes had no detectable central retinal function (NCRF) on mfERG; detectable but abnormal retinal function (DRF) was present in the mfERG of the other 15 eyes. RESULTS: The thickness of the ONL in the central macular region was significantly less in the NCRF eyes compared with that in both DRF eyes and controls. The ONL was significantly thinner in the pericentral region in both patient groups compared with that in controls, whereas the thickness of the GCL+IPL and INL+OPL was significantly decreased only in the NCRF eyes. The RNFL in the peripheral region was significantly thicker, whereas the thickness of the GCL+IPL and ONL was significantly thinner in both patient groups compared with that in controls. CONCLUSIONS: The results are consistent with degeneration of the outer retina preceding inner retinal changes in RP. OCT image segmentation enables objective evaluation of retinal structural changes in RP, with potential use in the planning of therapeutic interventions and conceivably as an outcome measure. SN - 1552-5783 UR - https://www.unboundmedicine.com/medline/citation/21948552/The_structure_and_function_of_the_macula_in_patients_with_advanced_retinitis_pigmentosa_ L2 - https://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.11-7780 DB - PRIME DP - Unbound Medicine ER -