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Pharmacological tests of hypotheses for acquired pendular nystagmus.
Ann N Y Acad Sci. 2011 Sep; 1233:320-6.AN

Abstract

Acquired pendular nystagmus (APN) occurs with multiple sclerosis (MS) and oculopalatal tremor (OPT); distinct features of the nystagmus have led to the development of separate models for their pathogenesis. APN in MS has been attributed to instability in the neural integrator, which normally ensures steady gaze. APN in OPT may result from electrotonic coupling between neurons in the hypertrophied inferior olivary nucleus, which induces maladaptive learning in cerebellar cortex. We tested these two hypotheses by analyzing the effects of gabapentin, memantine, and baclofen on both forms of nystagmus. No drug changed the dominant frequency of either form of APN, but the variability of frequency was affected with gabapentin and memantine in patients with OPT. The amplitude of APN in both MS and OPT was reduced with gabapentin and memantine, but not baclofen. Analyzing the effects of drug therapies on ocular oscillations provides a novel approach to test models of nystagmus.

Authors+Show Affiliations

Neurology Service, Veterans Medical Center and Case Western Reserve University, Cleveland, Ohio, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

21951011

Citation

Shaikh, Aasef G., et al. "Pharmacological Tests of Hypotheses for Acquired Pendular Nystagmus." Annals of the New York Academy of Sciences, vol. 1233, 2011, pp. 320-6.
Shaikh AG, Thurtell MJ, Optican LM, et al. Pharmacological tests of hypotheses for acquired pendular nystagmus. Ann N Y Acad Sci. 2011;1233:320-6.
Shaikh, A. G., Thurtell, M. J., Optican, L. M., & Leigh, R. J. (2011). Pharmacological tests of hypotheses for acquired pendular nystagmus. Annals of the New York Academy of Sciences, 1233, 320-6. https://doi.org/10.1111/j.1749-6632.2011.06118.x
Shaikh AG, et al. Pharmacological Tests of Hypotheses for Acquired Pendular Nystagmus. Ann N Y Acad Sci. 2011;1233:320-6. PubMed PMID: 21951011.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacological tests of hypotheses for acquired pendular nystagmus. AU - Shaikh,Aasef G, AU - Thurtell,Matthew J, AU - Optican,Lance M, AU - Leigh,R John, PY - 2011/9/29/entrez PY - 2011/9/29/pubmed PY - 2011/12/13/medline SP - 320 EP - 6 JF - Annals of the New York Academy of Sciences JO - Ann N Y Acad Sci VL - 1233 N2 - Acquired pendular nystagmus (APN) occurs with multiple sclerosis (MS) and oculopalatal tremor (OPT); distinct features of the nystagmus have led to the development of separate models for their pathogenesis. APN in MS has been attributed to instability in the neural integrator, which normally ensures steady gaze. APN in OPT may result from electrotonic coupling between neurons in the hypertrophied inferior olivary nucleus, which induces maladaptive learning in cerebellar cortex. We tested these two hypotheses by analyzing the effects of gabapentin, memantine, and baclofen on both forms of nystagmus. No drug changed the dominant frequency of either form of APN, but the variability of frequency was affected with gabapentin and memantine in patients with OPT. The amplitude of APN in both MS and OPT was reduced with gabapentin and memantine, but not baclofen. Analyzing the effects of drug therapies on ocular oscillations provides a novel approach to test models of nystagmus. SN - 1749-6632 UR - https://www.unboundmedicine.com/medline/citation/21951011/Pharmacological_tests_of_hypotheses_for_acquired_pendular_nystagmus_ L2 - https://doi.org/10.1111/j.1749-6632.2011.06118.x DB - PRIME DP - Unbound Medicine ER -