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Health-related quality of life, work productivity and health care resource use associated with constipation predominant irritable bowel syndrome.
Curr Med Res Opin. 2011 Nov; 27(11):2213-22.CM

Abstract

OBJECTIVES

Irritable bowel syndrome (IBS) is a common gastrointestinal disorder. Prevalence estimates of IBS vary widely, from 10 to 15%, in the U.S. However, few studies have examined constipation predominant IBS (IBS-C), a subtype of IBS. The aim of this study was to assess the effect of IBS-C on health-related quality of life (HRQOL), work productivity and activity impairment, and health care resource use.

METHODS

Using data from the 2007 U.S. National Health and Wellness Survey, IBS-C patients (n = 789) were compared to a propensity-score matched comparison group (n = 789). Differences between the groups were examined on HRQOL (SF-12v2), work productivity and activity impairment (WPAI questionnaire), and self-reported resource use in the last 6 months.

RESULTS

Patients with IBS-C reported significantly lower levels of HRQOL (physical component summary score: 41.55 [95% CI: 40.72-42.37] versus 44.49 [95% CI: 43.67-45.31]; mental component summary score: 40.58 [95% CI: 39.75-41.40] vs. 45.87 [95% CI: 45.04-46.70]) and significantly higher mean levels of presenteeism (31.72% [95% CI: 28.25%-35.61%] vs. 21.43% [95% CI: 19.03%-24.15%]), overall work impairment (35.54% [95% CI: 31.76%-39.76%] vs. 25.29% [95% CI: 22.59%-28.30%]), and activity impairment (45.78% [95% CI: 43.08%-48.66%] vs. 33.03% [95% CI: 31.08%-35.11%]) than matched comparators (all P values < 0.01). Patients with IBS-C reported significantly more provider visits (8.07 [95% CI: 7.38-8.82] vs. 5.55 [95% CI: 5.07-6.08]) and emergency room visits (0.57 [95% CI: 0.46-0.70] vs. 0.36 [95% CI: 0.29-0.45]) in the past 6 months (all Ps < 0.01). No statistically significant differences between the groups were observed in absenteeism or the number of the days hospitalized.

CONCLUSIONS

IBS-C was associated with poorer HRQOL, greater work productivity loss and activity impairment, and greater healthcare resource use. Limitations include the study's cross-sectional design and its self-reported nature. Nevertheless, improved management of IBS-C may reduce the humanistic and economic burden of the condition and benefit patients, employers, and the healthcare system.

Authors+Show Affiliations

Kantar Health, New York, NY 10010, USA. Marco.DiBonaventura@kantarhealth.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21951105

Citation

DiBonaventura, Marco, et al. "Health-related Quality of Life, Work Productivity and Health Care Resource Use Associated With Constipation Predominant Irritable Bowel Syndrome." Current Medical Research and Opinion, vol. 27, no. 11, 2011, pp. 2213-22.
DiBonaventura M, Sun SX, Bolge SC, et al. Health-related quality of life, work productivity and health care resource use associated with constipation predominant irritable bowel syndrome. Curr Med Res Opin. 2011;27(11):2213-22.
DiBonaventura, M., Sun, S. X., Bolge, S. C., Wagner, J. S., & Mody, R. (2011). Health-related quality of life, work productivity and health care resource use associated with constipation predominant irritable bowel syndrome. Current Medical Research and Opinion, 27(11), 2213-22. https://doi.org/10.1185/03007995.2011.623157
DiBonaventura M, et al. Health-related Quality of Life, Work Productivity and Health Care Resource Use Associated With Constipation Predominant Irritable Bowel Syndrome. Curr Med Res Opin. 2011;27(11):2213-22. PubMed PMID: 21951105.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Health-related quality of life, work productivity and health care resource use associated with constipation predominant irritable bowel syndrome. AU - DiBonaventura,Marco, AU - Sun,Shawn X, AU - Bolge,Susan C, AU - Wagner,Jan-Samuel, AU - Mody,Reema, Y1 - 2011/09/28/ PY - 2011/9/29/entrez PY - 2011/9/29/pubmed PY - 2012/6/8/medline SP - 2213 EP - 22 JF - Current medical research and opinion JO - Curr Med Res Opin VL - 27 IS - 11 N2 - OBJECTIVES: Irritable bowel syndrome (IBS) is a common gastrointestinal disorder. Prevalence estimates of IBS vary widely, from 10 to 15%, in the U.S. However, few studies have examined constipation predominant IBS (IBS-C), a subtype of IBS. The aim of this study was to assess the effect of IBS-C on health-related quality of life (HRQOL), work productivity and activity impairment, and health care resource use. METHODS: Using data from the 2007 U.S. National Health and Wellness Survey, IBS-C patients (n = 789) were compared to a propensity-score matched comparison group (n = 789). Differences between the groups were examined on HRQOL (SF-12v2), work productivity and activity impairment (WPAI questionnaire), and self-reported resource use in the last 6 months. RESULTS: Patients with IBS-C reported significantly lower levels of HRQOL (physical component summary score: 41.55 [95% CI: 40.72-42.37] versus 44.49 [95% CI: 43.67-45.31]; mental component summary score: 40.58 [95% CI: 39.75-41.40] vs. 45.87 [95% CI: 45.04-46.70]) and significantly higher mean levels of presenteeism (31.72% [95% CI: 28.25%-35.61%] vs. 21.43% [95% CI: 19.03%-24.15%]), overall work impairment (35.54% [95% CI: 31.76%-39.76%] vs. 25.29% [95% CI: 22.59%-28.30%]), and activity impairment (45.78% [95% CI: 43.08%-48.66%] vs. 33.03% [95% CI: 31.08%-35.11%]) than matched comparators (all P values < 0.01). Patients with IBS-C reported significantly more provider visits (8.07 [95% CI: 7.38-8.82] vs. 5.55 [95% CI: 5.07-6.08]) and emergency room visits (0.57 [95% CI: 0.46-0.70] vs. 0.36 [95% CI: 0.29-0.45]) in the past 6 months (all Ps < 0.01). No statistically significant differences between the groups were observed in absenteeism or the number of the days hospitalized. CONCLUSIONS: IBS-C was associated with poorer HRQOL, greater work productivity loss and activity impairment, and greater healthcare resource use. Limitations include the study's cross-sectional design and its self-reported nature. Nevertheless, improved management of IBS-C may reduce the humanistic and economic burden of the condition and benefit patients, employers, and the healthcare system. SN - 1473-4877 UR - https://www.unboundmedicine.com/medline/citation/21951105/Health_related_quality_of_life_work_productivity_and_health_care_resource_use_associated_with_constipation_predominant_irritable_bowel_syndrome_ L2 - https://www.tandfonline.com/doi/full/10.1185/03007995.2011.623157 DB - PRIME DP - Unbound Medicine ER -