Tags

Type your tag names separated by a space and hit enter

Reorganization of motor system in Parkinson's disease.
Eur Neurol. 2011; 66(4):220-6.EN

Abstract

BACKGROUND/AIMS

We investigated adaptive reorganization in Parkinson's disease (PD) by fMRI using a passive movement task and compared the brain activation patterns of 10 patients with left- versus right-sided dominant symptoms. Five healthy controls were also investigated with the same settings.

METHODS

We grouped patients according to the predominant side of symptoms; thus, a right-sided dominant and a left-sided dominant group was formed. The paradigm consisted of a 4-finger passive movement task, which altered with resting states. For each subject, this examination was performed twice: on the left and on the right hand separately.

RESULTS

In healthy controls, motor-related areas contralateral to the moving fingers showed activation on fMRI. Concerning PD patients, motor-related areas of the ipsilateral hemisphere - including the primary motor cortex, supplementary motor area, and basal ganglia - seemed to be involved in the motor reorganization in PD. However, we could only demonstrate this reorganization in patients with right-sided dominant symptoms.

CONCLUSIONS

We suggest that the human brain in PD tries to compensate for the failure of the basal ganglia motor loop by employing alternative (ipsilateral) motor pathways, indicating that a complex reorganization can also take place in disorders like PD which affect the whole motor-related network.

Authors+Show Affiliations

Department of Neurology, University of Pécs, Pécs, Hungary.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21952071

Citation

Kalmar, Zsuzsanna, et al. "Reorganization of Motor System in Parkinson's Disease." European Neurology, vol. 66, no. 4, 2011, pp. 220-6.
Kalmar Z, Kovacs N, Perlaki G, et al. Reorganization of motor system in Parkinson's disease. Eur Neurol. 2011;66(4):220-6.
Kalmar, Z., Kovacs, N., Perlaki, G., Nagy, F., Aschermann, Z., Kerekes, Z., Kaszas, B., Balas, I., Orsi, G., Komoly, S., Schwarcz, A., & Janszky, J. (2011). Reorganization of motor system in Parkinson's disease. European Neurology, 66(4), 220-6. https://doi.org/10.1159/000330658
Kalmar Z, et al. Reorganization of Motor System in Parkinson's Disease. Eur Neurol. 2011;66(4):220-6. PubMed PMID: 21952071.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reorganization of motor system in Parkinson's disease. AU - Kalmar,Zsuzsanna, AU - Kovacs,Norbert, AU - Perlaki,Gabor, AU - Nagy,Ferenc, AU - Aschermann,Zsuzsanna, AU - Kerekes,Zsuzsanna, AU - Kaszas,Beata, AU - Balas,Istvan, AU - Orsi,Gergely, AU - Komoly,Samuel, AU - Schwarcz,Attila, AU - Janszky,Jozsef, Y1 - 2011/09/23/ PY - 2010/12/10/received PY - 2011/06/22/accepted PY - 2011/9/29/entrez PY - 2011/9/29/pubmed PY - 2012/3/1/medline SP - 220 EP - 6 JF - European neurology JO - Eur. Neurol. VL - 66 IS - 4 N2 - BACKGROUND/AIMS: We investigated adaptive reorganization in Parkinson's disease (PD) by fMRI using a passive movement task and compared the brain activation patterns of 10 patients with left- versus right-sided dominant symptoms. Five healthy controls were also investigated with the same settings. METHODS: We grouped patients according to the predominant side of symptoms; thus, a right-sided dominant and a left-sided dominant group was formed. The paradigm consisted of a 4-finger passive movement task, which altered with resting states. For each subject, this examination was performed twice: on the left and on the right hand separately. RESULTS: In healthy controls, motor-related areas contralateral to the moving fingers showed activation on fMRI. Concerning PD patients, motor-related areas of the ipsilateral hemisphere - including the primary motor cortex, supplementary motor area, and basal ganglia - seemed to be involved in the motor reorganization in PD. However, we could only demonstrate this reorganization in patients with right-sided dominant symptoms. CONCLUSIONS: We suggest that the human brain in PD tries to compensate for the failure of the basal ganglia motor loop by employing alternative (ipsilateral) motor pathways, indicating that a complex reorganization can also take place in disorders like PD which affect the whole motor-related network. SN - 1421-9913 UR - https://www.unboundmedicine.com/medline/citation/21952071/Reorganization_of_motor_system_in_Parkinson's_disease_ L2 - https://www.karger.com?DOI=10.1159/000330658 DB - PRIME DP - Unbound Medicine ER -