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Abenquines A-D: aminoquinone derivatives produced by Streptomyces sp. strain DB634.
J Antibiot (Tokyo). 2011 Dec; 64(12):763-8.JA

Abstract

New bioactive secondary metabolites, called abenquines, were found in the fermentation broth of Streptomyces sp. strain DB634, which was isolated from the soils of the Chilean highland of the Atacama Desert. They are composed of an amino acid linked to an N-acetyl-aminobenzoquinone. Isolation of the abenquines (1-4), their structure elucidation by NMR analysis and MS, as well as the kinetics of their production are presented. The abenquines show inhibitory activity against bacteria, dermatophytic fungi and phosphodiesterase type 4b. The amino acid attached to the quinone is relevant to the enzyme inhibitory activity.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Schulz D
Kieler Wirkstoff-Zentrum at the Leibniz-Institute of Marine Sciences (IFM-GEOMAR), Kiel, Germany.
Beese P
No affiliation info available
Ohlendorf B
No affiliation info available
Erhard A
No affiliation info available
Zinecker H
No affiliation info available
Dorador C
No affiliation info available
Imhoff JF
No affiliation info available

MeSH

AnimalsAnti-Bacterial AgentsAntifungal AgentsCell SurvivalChileCyclic Nucleotide Phosphodiesterases, Type 4Desert ClimateEnzyme InhibitorsMiceMicrobial Sensitivity TestsNuclear Magnetic Resonance, BiomolecularOptical RotationQuinonesSoil MicrobiologySpectrometry, Mass, Electrospray IonizationSpectrophotometry, InfraredSpectrophotometry, UltravioletStreptomyces

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21952099

Citation

Schulz, Dirk, et al. "Abenquines A-D: Aminoquinone Derivatives Produced By Streptomyces Sp. Strain DB634." The Journal of Antibiotics, vol. 64, no. 12, 2011, pp. 763-8.
Schulz D, Beese P, Ohlendorf B, et al. Abenquines A-D: aminoquinone derivatives produced by Streptomyces sp. strain DB634. J Antibiot (Tokyo). 2011;64(12):763-8.
Schulz, D., Beese, P., Ohlendorf, B., Erhard, A., Zinecker, H., Dorador, C., & Imhoff, J. F. (2011). Abenquines A-D: aminoquinone derivatives produced by Streptomyces sp. strain DB634. The Journal of Antibiotics, 64(12), 763-8. https://doi.org/10.1038/ja.2011.87
Schulz D, et al. Abenquines A-D: Aminoquinone Derivatives Produced By Streptomyces Sp. Strain DB634. J Antibiot (Tokyo). 2011;64(12):763-8. PubMed PMID: 21952099.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Abenquines A-D: aminoquinone derivatives produced by Streptomyces sp. strain DB634. AU - Schulz,Dirk, AU - Beese,Pascal, AU - Ohlendorf,Birgit, AU - Erhard,Arlette, AU - Zinecker,Heidi, AU - Dorador,Cristina, AU - Imhoff,Johannes F, Y1 - 2011/09/28/ PY - 2011/9/29/entrez PY - 2011/9/29/pubmed PY - 2012/2/9/medline SP - 763 EP - 8 JF - The Journal of antibiotics JO - J Antibiot (Tokyo) VL - 64 IS - 12 N2 - New bioactive secondary metabolites, called abenquines, were found in the fermentation broth of Streptomyces sp. strain DB634, which was isolated from the soils of the Chilean highland of the Atacama Desert. They are composed of an amino acid linked to an N-acetyl-aminobenzoquinone. Isolation of the abenquines (1-4), their structure elucidation by NMR analysis and MS, as well as the kinetics of their production are presented. The abenquines show inhibitory activity against bacteria, dermatophytic fungi and phosphodiesterase type 4b. The amino acid attached to the quinone is relevant to the enzyme inhibitory activity. SN - 1881-1469 UR - https://www.unboundmedicine.com/medline/citation/21952099/Abenquines_A_D:_aminoquinone_derivatives_produced_by_Streptomyces_sp__strain_DB634_ L2 - https://doi.org/10.1038/ja.2011.87 DB - PRIME DP - Unbound Medicine ER -