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Effect of soy and milk protein supplementation on serum lipid levels: a randomized controlled trial.
Eur J Clin Nutr. 2012 Apr; 66(4):419-25.EJ

Abstract

BACKGROUND/OBJECTIVE

Previous clinical trials have documented that soy protein reduces low-density lipoprotein cholesterol and increases high-density lipoprotein (HDL) cholesterol compared with milk protein. However, the effect of soy protein on lipids compared with carbohydrate has not been not well studied. We examined the effect of soy and milk protein supplementation on lipids and lipoproteins compared with carbohydrate among adults without hypercholesterolemia.

SUBJECTS/METHODS

We conducted a randomized, double-blind, 3-phase crossover trial among 352 US adults with serum total cholesterol level of <240 mg/dl from September 2003 to April 2008. Trial participants were assigned to 40 g/day supplementation of soy protein, milk protein or complex carbohydrate from wheat each for 8 weeks in random order with a 3-week washout period between interventions. Overnight fasting blood samples were collected at the termination of each intervention phase.

RESULTS

Compared with carbohydrate, soy protein supplementation was significantly associated with a net change (95% confidence interval (CI)) in total cholesterol and total/HDL cholesterol ratio of -3.97 mg/dl (-7.63 to -0.31, P=0.03) and -0.12 (-0.23 to -0.01, P=0.03), respectively. Compared with milk protein, soy protein supplementation was significantly associated with a net change (95% CI) in HDL and total/HDL cholesterol ratio of 1.54 mg/dl (0.63 to 2.44, P=0.0009) and -0.14 (-0.22 to -0.05, P=0.001), respectively. Compared with carbohydrate, milk protein supplementation was significantly associated with a net change (95% CI) in HDL of -1.13 mg/dl (-2.05 to -0.22, P=0.02).

CONCLUSIONS

This randomized controlled trial indicates that soy protein, but not milk protein, supplementation improves the lipid profile among healthy individuals.

Authors+Show Affiliations

Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

21952693

Citation

Wofford, M R., et al. "Effect of Soy and Milk Protein Supplementation On Serum Lipid Levels: a Randomized Controlled Trial." European Journal of Clinical Nutrition, vol. 66, no. 4, 2012, pp. 419-25.
Wofford MR, Rebholz CM, Reynolds K, et al. Effect of soy and milk protein supplementation on serum lipid levels: a randomized controlled trial. Eur J Clin Nutr. 2012;66(4):419-25.
Wofford, M. R., Rebholz, C. M., Reynolds, K., Chen, J., Chen, C. S., Myers, L., Xu, J., Jones, D. W., Whelton, P. K., & He, J. (2012). Effect of soy and milk protein supplementation on serum lipid levels: a randomized controlled trial. European Journal of Clinical Nutrition, 66(4), 419-25. https://doi.org/10.1038/ejcn.2011.168
Wofford MR, et al. Effect of Soy and Milk Protein Supplementation On Serum Lipid Levels: a Randomized Controlled Trial. Eur J Clin Nutr. 2012;66(4):419-25. PubMed PMID: 21952693.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of soy and milk protein supplementation on serum lipid levels: a randomized controlled trial. AU - Wofford,M R, AU - Rebholz,C M, AU - Reynolds,K, AU - Chen,J, AU - Chen,C-S, AU - Myers,L, AU - Xu,J, AU - Jones,D W, AU - Whelton,P K, AU - He,J, Y1 - 2011/09/28/ PY - 2011/9/29/entrez PY - 2011/9/29/pubmed PY - 2012/7/31/medline SP - 419 EP - 25 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 66 IS - 4 N2 - BACKGROUND/OBJECTIVE: Previous clinical trials have documented that soy protein reduces low-density lipoprotein cholesterol and increases high-density lipoprotein (HDL) cholesterol compared with milk protein. However, the effect of soy protein on lipids compared with carbohydrate has not been not well studied. We examined the effect of soy and milk protein supplementation on lipids and lipoproteins compared with carbohydrate among adults without hypercholesterolemia. SUBJECTS/METHODS: We conducted a randomized, double-blind, 3-phase crossover trial among 352 US adults with serum total cholesterol level of <240 mg/dl from September 2003 to April 2008. Trial participants were assigned to 40 g/day supplementation of soy protein, milk protein or complex carbohydrate from wheat each for 8 weeks in random order with a 3-week washout period between interventions. Overnight fasting blood samples were collected at the termination of each intervention phase. RESULTS: Compared with carbohydrate, soy protein supplementation was significantly associated with a net change (95% confidence interval (CI)) in total cholesterol and total/HDL cholesterol ratio of -3.97 mg/dl (-7.63 to -0.31, P=0.03) and -0.12 (-0.23 to -0.01, P=0.03), respectively. Compared with milk protein, soy protein supplementation was significantly associated with a net change (95% CI) in HDL and total/HDL cholesterol ratio of 1.54 mg/dl (0.63 to 2.44, P=0.0009) and -0.14 (-0.22 to -0.05, P=0.001), respectively. Compared with carbohydrate, milk protein supplementation was significantly associated with a net change (95% CI) in HDL of -1.13 mg/dl (-2.05 to -0.22, P=0.02). CONCLUSIONS: This randomized controlled trial indicates that soy protein, but not milk protein, supplementation improves the lipid profile among healthy individuals. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/21952693/Effect_of_soy_and_milk_protein_supplementation_on_serum_lipid_levels:_a_randomized_controlled_trial_ L2 - http://dx.doi.org/10.1038/ejcn.2011.168 DB - PRIME DP - Unbound Medicine ER -