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Folate, vitamin B(6) , vitamin B(12) , methionine and alcohol intake in relation to ovarian cancer risk.
Int J Cancer 2012; 131(4):E518-29IJ

Abstract

Folate, methionine, vitamin B(6) and vitamin B(12) may influence carcinogenesis due to their roles in the one-carbon metabolism pathway, which is critical for DNA synthesis, methylation and repair. Low intake of these nutrients has been associated with an increased risk of breast, colon and endometrial cancers. Previous studies that have examined the relation between these nutrients and ovarian cancer risk have been inconsistent and have had limited power to examine the relation by histologic subtype. We investigated the association between folate, methionine, vitamin B(6) , vitamin B(12) and alcohol among 1910 women with ovarian cancer and 1989 controls from a case-control study conducted in eastern Massachusetts and New Hampshire from 1992 to 2008. Diet was assessed via food frequency questionnaire. Participants were asked to recall diet one-year before diagnosis or interview. Logistic regression models were used to calculate odds ratios (OR) and 95% confidence intervals (95% CIs). We also examined whether the associations varied by ovarian cancer histologies using polytomous logistic regression. We observed an inverse association between dietary vitamin B(6) (covariate-adjusted OR = 0.76, 95% CI 0.64-0.92; p(trend) = 0.002) and methionine intake (covariate-adjusted OR = 0.72, 95% CI = 0.60-0.87; p(trend) < 0.001) and ovarian cancer risk comparing the highest to lowest quartile. The association with dietary vitamin B(6) was strongest for serous borderline (covariate-adjusted OR = 0.49, 95% CI = 0.32-0.77; p(trend) = 0.001) and serous invasive (covariate-adjusted OR = 0.74, 95% CI = 0.58-0.94; p(trend) = 0.012) subtypes. Overall, we observed no significant association between folate and ovarian cancer risk. One-carbon metabolism related nutrients, especially vitamin B(6) and methionine, may lower ovarian cancer risk.

Authors+Show Affiliations

Brigham and Women's Hospital, Boston, MA, USA. holly.harris@channing.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

21953625

Citation

Harris, Holly R., et al. "Folate, Vitamin B(6) , Vitamin B(12) , Methionine and Alcohol Intake in Relation to Ovarian Cancer Risk." International Journal of Cancer, vol. 131, no. 4, 2012, pp. E518-29.
Harris HR, Cramer DW, Vitonis AF, et al. Folate, vitamin B(6) , vitamin B(12) , methionine and alcohol intake in relation to ovarian cancer risk. Int J Cancer. 2012;131(4):E518-29.
Harris, H. R., Cramer, D. W., Vitonis, A. F., DePari, M., & Terry, K. L. (2012). Folate, vitamin B(6) , vitamin B(12) , methionine and alcohol intake in relation to ovarian cancer risk. International Journal of Cancer, 131(4), pp. E518-29. doi:10.1002/ijc.26455.
Harris HR, et al. Folate, Vitamin B(6) , Vitamin B(12) , Methionine and Alcohol Intake in Relation to Ovarian Cancer Risk. Int J Cancer. 2012 Aug 15;131(4):E518-29. PubMed PMID: 21953625.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Folate, vitamin B(6) , vitamin B(12) , methionine and alcohol intake in relation to ovarian cancer risk. AU - Harris,Holly R, AU - Cramer,Daniel W, AU - Vitonis,Allison F, AU - DePari,Mary, AU - Terry,Kathryn L, Y1 - 2011/11/08/ PY - 2011/06/20/received PY - 2011/09/16/accepted PY - 2011/9/29/entrez PY - 2011/9/29/pubmed PY - 2012/9/1/medline SP - E518 EP - 29 JF - International journal of cancer JO - Int. J. Cancer VL - 131 IS - 4 N2 - Folate, methionine, vitamin B(6) and vitamin B(12) may influence carcinogenesis due to their roles in the one-carbon metabolism pathway, which is critical for DNA synthesis, methylation and repair. Low intake of these nutrients has been associated with an increased risk of breast, colon and endometrial cancers. Previous studies that have examined the relation between these nutrients and ovarian cancer risk have been inconsistent and have had limited power to examine the relation by histologic subtype. We investigated the association between folate, methionine, vitamin B(6) , vitamin B(12) and alcohol among 1910 women with ovarian cancer and 1989 controls from a case-control study conducted in eastern Massachusetts and New Hampshire from 1992 to 2008. Diet was assessed via food frequency questionnaire. Participants were asked to recall diet one-year before diagnosis or interview. Logistic regression models were used to calculate odds ratios (OR) and 95% confidence intervals (95% CIs). We also examined whether the associations varied by ovarian cancer histologies using polytomous logistic regression. We observed an inverse association between dietary vitamin B(6) (covariate-adjusted OR = 0.76, 95% CI 0.64-0.92; p(trend) = 0.002) and methionine intake (covariate-adjusted OR = 0.72, 95% CI = 0.60-0.87; p(trend) < 0.001) and ovarian cancer risk comparing the highest to lowest quartile. The association with dietary vitamin B(6) was strongest for serous borderline (covariate-adjusted OR = 0.49, 95% CI = 0.32-0.77; p(trend) = 0.001) and serous invasive (covariate-adjusted OR = 0.74, 95% CI = 0.58-0.94; p(trend) = 0.012) subtypes. Overall, we observed no significant association between folate and ovarian cancer risk. One-carbon metabolism related nutrients, especially vitamin B(6) and methionine, may lower ovarian cancer risk. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/21953625/Folate_vitamin_B_6___vitamin_B_12___methionine_and_alcohol_intake_in_relation_to_ovarian_cancer_risk_ L2 - https://doi.org/10.1002/ijc.26455 DB - PRIME DP - Unbound Medicine ER -