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Switching patients with uncontrolled hypertension on amlodipine 10 mg to single-pill combinations of telmisartan and amlodipine: results of the TEAMSTA-10 study.
Curr Med Res Opin. 2011 Nov; 27(11):2145-53.CM

Abstract

OBJECTIVE

To evaluate the efficacy and safety of two different strengths of single-pill combinations of the angiotensin II receptor blocker telmisartan 40 or 80 mg (T40 or T80) and the calcium channel blocker amlodipine 10 mg (A10) compared with that of A10 monotherapy in a hypertensive patient population whose blood pressure was not controlled by A10.

RESEARCH DESIGN AND METHODS

An 8-week, randomized, double-blind, controlled study to compare the efficacy and safety of single-pill combinations of T40/A10 or T80/A10 versus A10 monotherapy in 947 patients with uncontrolled hypertension (diastolic blood pressure [DBP] ≥90 mmHg after 6 weeks' A10).

MAIN OUTCOME MEASURES

The primary end point was change from baseline in seated in-clinic trough cuff DBP after 8 weeks. Secondary efficacy end points included change from baseline in seated in-clinic trough cuff systolic blood pressure (SBP), and the proportion of patients achieving SBP/DBP response (<140/90 mmHg or ≥10/15 mmHg reduction) and SBP/DBP goal (<140/90 mmHg) after 8 weeks' treatment. Adverse events were recorded throughout.

RESULTS

In a patient population who had failed to achieve DBP goal with A10, T40/A10 and T80/A10 resulted in significantly greater (P < 0.0001) reductions in seated trough SBP/DBP versus A10 (-3.7/-2.8 mmHg; -3.9/-2.8 mmHg), significantly higher SBP/DBP goal rates versus A10 (58.8/63.7% and 60.3/66.5% vs. 50.2/51.1%), and significantly higher SBP/DBP response rates with T40-80/A10 versus A10 (64.7/66.0% and 65.8/68.7% vs. 54.1/53.4%). T40-80/A10 were well tolerated. Rates of peripheral edema adverse events were low (6.7-8.5%) and not significantly different between the treatment groups; however, patients were pre-screened for intolerance to A10.

CONCLUSIONS

Switching patients who fail to achieve blood pressure goal with A10 to a single-pill combination of T40/A10 or T80/A10 results in superior SBP/DBP reductions, and SBP/DBP goal and response rates.

Authors+Show Affiliations

Rødovre Centrum, Rødovre, Denmark. neldam@dadlnet.dkNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21955225

Citation

Neldam, Steen, et al. "Switching Patients With Uncontrolled Hypertension On Amlodipine 10 Mg to Single-pill Combinations of Telmisartan and Amlodipine: Results of the TEAMSTA-10 Study." Current Medical Research and Opinion, vol. 27, no. 11, 2011, pp. 2145-53.
Neldam S, Edwards C, Jones R, et al. Switching patients with uncontrolled hypertension on amlodipine 10 mg to single-pill combinations of telmisartan and amlodipine: results of the TEAMSTA-10 study. Curr Med Res Opin. 2011;27(11):2145-53.
Neldam, S., Edwards, C., & Jones, R. (2011). Switching patients with uncontrolled hypertension on amlodipine 10 mg to single-pill combinations of telmisartan and amlodipine: results of the TEAMSTA-10 study. Current Medical Research and Opinion, 27(11), 2145-53. https://doi.org/10.1185/03007995.2011.624089
Neldam S, et al. Switching Patients With Uncontrolled Hypertension On Amlodipine 10 Mg to Single-pill Combinations of Telmisartan and Amlodipine: Results of the TEAMSTA-10 Study. Curr Med Res Opin. 2011;27(11):2145-53. PubMed PMID: 21955225.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Switching patients with uncontrolled hypertension on amlodipine 10 mg to single-pill combinations of telmisartan and amlodipine: results of the TEAMSTA-10 study. AU - Neldam,Steen, AU - Edwards,Colin, AU - Jones,Russell, AU - ,, Y1 - 2011/09/29/ PY - 2011/9/30/entrez PY - 2011/10/1/pubmed PY - 2012/6/8/medline SP - 2145 EP - 53 JF - Current medical research and opinion JO - Curr Med Res Opin VL - 27 IS - 11 N2 - OBJECTIVE: To evaluate the efficacy and safety of two different strengths of single-pill combinations of the angiotensin II receptor blocker telmisartan 40 or 80 mg (T40 or T80) and the calcium channel blocker amlodipine 10 mg (A10) compared with that of A10 monotherapy in a hypertensive patient population whose blood pressure was not controlled by A10. RESEARCH DESIGN AND METHODS: An 8-week, randomized, double-blind, controlled study to compare the efficacy and safety of single-pill combinations of T40/A10 or T80/A10 versus A10 monotherapy in 947 patients with uncontrolled hypertension (diastolic blood pressure [DBP] ≥90 mmHg after 6 weeks' A10). MAIN OUTCOME MEASURES: The primary end point was change from baseline in seated in-clinic trough cuff DBP after 8 weeks. Secondary efficacy end points included change from baseline in seated in-clinic trough cuff systolic blood pressure (SBP), and the proportion of patients achieving SBP/DBP response (<140/90 mmHg or ≥10/15 mmHg reduction) and SBP/DBP goal (<140/90 mmHg) after 8 weeks' treatment. Adverse events were recorded throughout. RESULTS: In a patient population who had failed to achieve DBP goal with A10, T40/A10 and T80/A10 resulted in significantly greater (P < 0.0001) reductions in seated trough SBP/DBP versus A10 (-3.7/-2.8 mmHg; -3.9/-2.8 mmHg), significantly higher SBP/DBP goal rates versus A10 (58.8/63.7% and 60.3/66.5% vs. 50.2/51.1%), and significantly higher SBP/DBP response rates with T40-80/A10 versus A10 (64.7/66.0% and 65.8/68.7% vs. 54.1/53.4%). T40-80/A10 were well tolerated. Rates of peripheral edema adverse events were low (6.7-8.5%) and not significantly different between the treatment groups; however, patients were pre-screened for intolerance to A10. CONCLUSIONS: Switching patients who fail to achieve blood pressure goal with A10 to a single-pill combination of T40/A10 or T80/A10 results in superior SBP/DBP reductions, and SBP/DBP goal and response rates. SN - 1473-4877 UR - https://www.unboundmedicine.com/medline/citation/21955225/Switching_patients_with_uncontrolled_hypertension_on_amlodipine_10_mg_to_single_pill_combinations_of_telmisartan_and_amlodipine:_results_of_the_TEAMSTA_10_study_ DB - PRIME DP - Unbound Medicine ER -