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Effects of inositol supplementation in a cohort of mothers at risk of producing an NTD pregnancy.
Birth Defects Res A Clin Mol Teratol. 2011 Nov; 91(11):962-5.BD

Abstract

Neural tube defects (NTDs), most commonly spina bifida and anencephaly, can be prevented with periconceptional intake of folic acid in about 70% of cases. Recurrence of NTDs despite supplementation of high dose of folic acid further suggests that a proportion of NTD cases might be resistant to folic acid. Moreover, heterogeneity of NTDs has been suggested in animal studies, indicating that only some sub-type of NTDs should be considered sensitive to folate intake. Inositol isomers (particularly myo- and chiro-inositol) can prevent folate-resistant NTDs in the curly-tail mutant mouse, suggesting that some cases of human NTDs might benefit from inositol supplementation. In humans, lower inositol blood concentration was found in pregnant women carrying NTD fetuses, whereas a periconceptional combination therapy with folic acid associated with inositol has been linked to normal live births, despite high NTD recurrence risk. Fifteen pregnancies from 12 Caucasian women from different parts of Italy with at least one previous NTD-affected pregnancy underwent periconceptional combined myo-inositol and folic acid supplementation. Maternal serum α-feto-protein levels were found in the normal range, and normal results on ultrasound examination were found in all the pregnancies that followed. No collateral effects or intense uterine contractions were demonstrated in this pilot study in any of the pregnancies after inositol supplementation, and seventeen babies were born without any type of NTD.

Authors+Show Affiliations

Servizio di Genetica, AO Istituti Ospitalieri, Cremona, Italy. p.cavalli@ospedale.cremona.itNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21956977

Citation

Cavalli, Pietro, et al. "Effects of Inositol Supplementation in a Cohort of Mothers at Risk of Producing an NTD Pregnancy." Birth Defects Research. Part A, Clinical and Molecular Teratology, vol. 91, no. 11, 2011, pp. 962-5.
Cavalli P, Tonni G, Grosso E, et al. Effects of inositol supplementation in a cohort of mothers at risk of producing an NTD pregnancy. Birth Defects Res A Clin Mol Teratol. 2011;91(11):962-5.
Cavalli, P., Tonni, G., Grosso, E., & Poggiani, C. (2011). Effects of inositol supplementation in a cohort of mothers at risk of producing an NTD pregnancy. Birth Defects Research. Part A, Clinical and Molecular Teratology, 91(11), 962-5. https://doi.org/10.1002/bdra.22853
Cavalli P, et al. Effects of Inositol Supplementation in a Cohort of Mothers at Risk of Producing an NTD Pregnancy. Birth Defects Res A Clin Mol Teratol. 2011;91(11):962-5. PubMed PMID: 21956977.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of inositol supplementation in a cohort of mothers at risk of producing an NTD pregnancy. AU - Cavalli,Pietro, AU - Tonni,Gabriele, AU - Grosso,Enrico, AU - Poggiani,Carlo, Y1 - 2011/09/28/ PY - 2011/02/23/received PY - 2011/07/05/revised PY - 2011/07/11/accepted PY - 2011/9/30/entrez PY - 2011/10/1/pubmed PY - 2012/3/16/medline SP - 962 EP - 5 JF - Birth defects research. Part A, Clinical and molecular teratology JO - Birth Defects Res A Clin Mol Teratol VL - 91 IS - 11 N2 - Neural tube defects (NTDs), most commonly spina bifida and anencephaly, can be prevented with periconceptional intake of folic acid in about 70% of cases. Recurrence of NTDs despite supplementation of high dose of folic acid further suggests that a proportion of NTD cases might be resistant to folic acid. Moreover, heterogeneity of NTDs has been suggested in animal studies, indicating that only some sub-type of NTDs should be considered sensitive to folate intake. Inositol isomers (particularly myo- and chiro-inositol) can prevent folate-resistant NTDs in the curly-tail mutant mouse, suggesting that some cases of human NTDs might benefit from inositol supplementation. In humans, lower inositol blood concentration was found in pregnant women carrying NTD fetuses, whereas a periconceptional combination therapy with folic acid associated with inositol has been linked to normal live births, despite high NTD recurrence risk. Fifteen pregnancies from 12 Caucasian women from different parts of Italy with at least one previous NTD-affected pregnancy underwent periconceptional combined myo-inositol and folic acid supplementation. Maternal serum α-feto-protein levels were found in the normal range, and normal results on ultrasound examination were found in all the pregnancies that followed. No collateral effects or intense uterine contractions were demonstrated in this pilot study in any of the pregnancies after inositol supplementation, and seventeen babies were born without any type of NTD. SN - 1542-0760 UR - https://www.unboundmedicine.com/medline/citation/21956977/Effects_of_inositol_supplementation_in_a_cohort_of_mothers_at_risk_of_producing_an_NTD_pregnancy_ L2 - https://doi.org/10.1002/bdra.22853 DB - PRIME DP - Unbound Medicine ER -