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Baicalein inhibits oxidative stress-induced cellular damage via antioxidant effects.
Toxicol Ind Health. 2012 Jun; 28(5):412-21.TI

Abstract

Baicalein (5,6,7-trihydroxyflavone) is a phenolic flavonoid compound derived mainly from the root of Scutellaria baicalensis Georgi, a medicinal plant traditionally used in oriental medicine. In our previous study, baicalein attenuated mitochondrial oxidative stress by scavenging reactive oxygen species (ROS) and by induction of nuclear factor erythroid 2-related factor 2 transcription factor-mediated manganese superoxide dismutase. In the present study, the protective effects of baicalein against oxidative stress-induced damage, especially cellular components including DNA, lipid, and protein, were studied. The results of this study showed that baicalein scavenged intracellular ROS. Baicalein inhibited the H₂O₂-induced DNA damage that was demonstrated by decreased phospho-H2A.X expression and DNA tail formation. In addition, it prevented the lipid peroxidation shown by the fluorescence intensity of diphenyl-1-pyrenylphosphine and the formation of thiobarbituric acid reactive substances. Moreover, baicalein inhibited protein oxidation demonstrated by protein carbonyl formation. Furthermore, baicalein protected cells via the inhibition of apoptosis induced by H₂O₂. The findings of this study suggest that baicalein provides protection for cellular components against oxidative damage via scavenging ROS and inhibiting apoptosis.

Authors+Show Affiliations

School of Medicine and Applied Radiological Science Research Institute, Jeju National University, Jeju, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21957089

Citation

Kang, Kyoung Ah, et al. "Baicalein Inhibits Oxidative Stress-induced Cellular Damage Via Antioxidant Effects." Toxicology and Industrial Health, vol. 28, no. 5, 2012, pp. 412-21.
Kang KA, Zhang R, Piao MJ, et al. Baicalein inhibits oxidative stress-induced cellular damage via antioxidant effects. Toxicol Ind Health. 2012;28(5):412-21.
Kang, K. A., Zhang, R., Piao, M. J., Chae, S., Kim, H. S., Park, J. H., Jung, K. S., & Hyun, J. W. (2012). Baicalein inhibits oxidative stress-induced cellular damage via antioxidant effects. Toxicology and Industrial Health, 28(5), 412-21. https://doi.org/10.1177/0748233711413799
Kang KA, et al. Baicalein Inhibits Oxidative Stress-induced Cellular Damage Via Antioxidant Effects. Toxicol Ind Health. 2012;28(5):412-21. PubMed PMID: 21957089.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Baicalein inhibits oxidative stress-induced cellular damage via antioxidant effects. AU - Kang,Kyoung Ah, AU - Zhang,Rui, AU - Piao,Mei Jing, AU - Chae,Sungwook, AU - Kim,Hee Sun, AU - Park,Jun Ho, AU - Jung,Kwang Sun, AU - Hyun,Jin Won, Y1 - 2011/09/28/ PY - 2011/9/30/entrez PY - 2011/10/1/pubmed PY - 2012/12/15/medline SP - 412 EP - 21 JF - Toxicology and industrial health JO - Toxicol Ind Health VL - 28 IS - 5 N2 - Baicalein (5,6,7-trihydroxyflavone) is a phenolic flavonoid compound derived mainly from the root of Scutellaria baicalensis Georgi, a medicinal plant traditionally used in oriental medicine. In our previous study, baicalein attenuated mitochondrial oxidative stress by scavenging reactive oxygen species (ROS) and by induction of nuclear factor erythroid 2-related factor 2 transcription factor-mediated manganese superoxide dismutase. In the present study, the protective effects of baicalein against oxidative stress-induced damage, especially cellular components including DNA, lipid, and protein, were studied. The results of this study showed that baicalein scavenged intracellular ROS. Baicalein inhibited the H₂O₂-induced DNA damage that was demonstrated by decreased phospho-H2A.X expression and DNA tail formation. In addition, it prevented the lipid peroxidation shown by the fluorescence intensity of diphenyl-1-pyrenylphosphine and the formation of thiobarbituric acid reactive substances. Moreover, baicalein inhibited protein oxidation demonstrated by protein carbonyl formation. Furthermore, baicalein protected cells via the inhibition of apoptosis induced by H₂O₂. The findings of this study suggest that baicalein provides protection for cellular components against oxidative damage via scavenging ROS and inhibiting apoptosis. SN - 1477-0393 UR - https://www.unboundmedicine.com/medline/citation/21957089/Baicalein_inhibits_oxidative_stress_induced_cellular_damage_via_antioxidant_effects_ L2 - https://journals.sagepub.com/doi/10.1177/0748233711413799?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -