Prime

Type your tag names separated by a space and hit enter

Relationship between occupation attributes and brain metabolism in frontotemporal dementia.

Abstract

Occupation has been associated with cognitive reserve in healthy aging and Alzheimer's disease. Here we assess the relationship between cerebral metabolic deficits in behavioral variant frontotemporal dementia (bvFTD) and occupation characteristics. Using factor analysis, we derived verbal, physical and visuospatial occupation scores from the US Department of Labor, Occupational Information Network and related these scores to regional cerebral metabolic rate of glucose utilization in 31 patients diagnosed with behavioral variant bvFTD, controlling for cognitive status (CERAD neuropsychological assessment battery), gender and education. Regression analyses showed a marked inverse association between glucose metabolism and (a) verbal occupation scores in left prefrontal cortex and, (b) physical occupation characteristics in right supplementary motor area. We concluded that, consistent with the cognitive reserve hypothesis, lifelong occupation characteristics are related to focal cerebral metabolic deficits in bvFTD. Specific occupation demands spanning decades may strengthen cognitive resistance to pathology.

Links

  • Publisher Full Text
  • Authors

    , , , , ,

    Source

    Neuropsychologia 49:13 2011 Nov pg 3699-703

    MeSH

    Aged
    Brain
    Brain Mapping
    Cognition Disorders
    Factor Analysis, Statistical
    Female
    Fluorodeoxyglucose F18
    Frontotemporal Dementia
    Humans
    Male
    Mental Status Schedule
    Middle Aged
    Motor Activity
    Neuropsychological Tests
    Occupations
    Photic Stimulation
    Positron-Emission Tomography
    Regression Analysis
    Space Perception
    Verbal Behavior

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21958648