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Relationship between occupation attributes and brain metabolism in frontotemporal dementia.
Neuropsychologia. 2011 Nov; 49(13):3699-703.N

Abstract

Occupation has been associated with cognitive reserve in healthy aging and Alzheimer's disease. Here we assess the relationship between cerebral metabolic deficits in behavioral variant frontotemporal dementia (bvFTD) and occupation characteristics. Using factor analysis, we derived verbal, physical and visuospatial occupation scores from the US Department of Labor, Occupational Information Network and related these scores to regional cerebral metabolic rate of glucose utilization in 31 patients diagnosed with behavioral variant bvFTD, controlling for cognitive status (CERAD neuropsychological assessment battery), gender and education. Regression analyses showed a marked inverse association between glucose metabolism and (a) verbal occupation scores in left prefrontal cortex and, (b) physical occupation characteristics in right supplementary motor area. We concluded that, consistent with the cognitive reserve hypothesis, lifelong occupation characteristics are related to focal cerebral metabolic deficits in bvFTD. Specific occupation demands spanning decades may strengthen cognitive resistance to pathology.

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Authors+Show Affiliations

Spreng RN
Department of Psychology, Harvard University, Cambridge, MA 02138, USA. nathan.spreng@gmail.com
Drzezga A
No affiliation info available
Diehl-Schmid J
No affiliation info available
Kurz A
No affiliation info available
Levine B
No affiliation info available
Perneczky R
No affiliation info available

MeSH

AgedBrainBrain MappingCognition DisordersFactor Analysis, StatisticalFemaleFluorodeoxyglucose F18Frontotemporal DementiaHumansMaleMental Status ScheduleMiddle AgedMotor ActivityNeuropsychological TestsOccupationsPhotic StimulationPositron-Emission TomographyRegression AnalysisSpace PerceptionVerbal Behavior

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21958648

Citation

Spreng, R Nathan, et al. "Relationship Between Occupation Attributes and Brain Metabolism in Frontotemporal Dementia." Neuropsychologia, vol. 49, no. 13, 2011, pp. 3699-703.
Spreng RN, Drzezga A, Diehl-Schmid J, et al. Relationship between occupation attributes and brain metabolism in frontotemporal dementia. Neuropsychologia. 2011;49(13):3699-703.
Spreng, R. N., Drzezga, A., Diehl-Schmid, J., Kurz, A., Levine, B., & Perneczky, R. (2011). Relationship between occupation attributes and brain metabolism in frontotemporal dementia. Neuropsychologia, 49(13), 3699-703. https://doi.org/10.1016/j.neuropsychologia.2011.09.025
Spreng RN, et al. Relationship Between Occupation Attributes and Brain Metabolism in Frontotemporal Dementia. Neuropsychologia. 2011;49(13):3699-703. PubMed PMID: 21958648.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between occupation attributes and brain metabolism in frontotemporal dementia. AU - Spreng,R Nathan, AU - Drzezga,Alexander, AU - Diehl-Schmid,Janine, AU - Kurz,Alexander, AU - Levine,Brian, AU - Perneczky,Robert, Y1 - 2011/09/21/ PY - 2011/02/15/received PY - 2011/07/28/revised PY - 2011/09/15/accepted PY - 2011/10/1/entrez PY - 2011/10/1/pubmed PY - 2012/3/6/medline SP - 3699 EP - 703 JF - Neuropsychologia JO - Neuropsychologia VL - 49 IS - 13 N2 - Occupation has been associated with cognitive reserve in healthy aging and Alzheimer's disease. Here we assess the relationship between cerebral metabolic deficits in behavioral variant frontotemporal dementia (bvFTD) and occupation characteristics. Using factor analysis, we derived verbal, physical and visuospatial occupation scores from the US Department of Labor, Occupational Information Network and related these scores to regional cerebral metabolic rate of glucose utilization in 31 patients diagnosed with behavioral variant bvFTD, controlling for cognitive status (CERAD neuropsychological assessment battery), gender and education. Regression analyses showed a marked inverse association between glucose metabolism and (a) verbal occupation scores in left prefrontal cortex and, (b) physical occupation characteristics in right supplementary motor area. We concluded that, consistent with the cognitive reserve hypothesis, lifelong occupation characteristics are related to focal cerebral metabolic deficits in bvFTD. Specific occupation demands spanning decades may strengthen cognitive resistance to pathology. SN - 1873-3514 UR - https://www.unboundmedicine.com/medline/citation/21958648/Relationship_between_occupation_attributes_and_brain_metabolism_in_frontotemporal_dementia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0028-3932(11)00432-5 DB - PRIME DP - Unbound Medicine ER -