Tags

Type your tag names separated by a space and hit enter

Digitized assessment of mammographic breast density--effects of continuous combined hormone therapy, tibolone and black cohosh compared to placebo.
Maturitas. 2011 Dec; 70(4):361-4.M

Abstract

OBJECTIVES

To determine the effects of continuous combined hormone therapy, tibolone, black cohosh, and placebo on digitized mammographic breast density in postmenopausal women.

STUDY DESIGN

A prospective, double-blind, placebo-controlled study of 154 postmenopausal women randomized to estradiol 2 mg/norethisterone acetate 1 mg (E2/NETA), tibolone 2.5 mg or placebo and a prospective, open, uncontrolled drug safety study, of which 65 postmenopausal women were treated with black cohosh. Mammograms, at baseline and after six months of treatment, were previously classified according to visual quantification scales.

MAIN OUTCOME MEASURES

Reanalysis of assessable mammograms by digitized quantification of breast density.

RESULTS

Treatment groups were comparable at baseline. During treatment, both E2/NETA and tibolone significantly increased breast density (mean increase 14.3%, p<0.001 and 2.3%, p<0.001, respectively), while black cohosh and placebo did not. Twenty-four out of the 43 women on E2/NETA had an increase in density exceeding 10% and 6 women had an increase of 30% or more. In the tibolone group, only one woman had an increase in density of more than 10%. The difference in increase in breast density between E2/NETA on the one hand and tibolone, black cohosh and placebo on the other was highly significant (p<0.0001).

CONCLUSIONS

Digitized mammographic breast density is a highly sensitive method confirming significant increase in density by standard E2/NETA treatment and to a lesser extent by tibolone, whereas black cohosh does not influence mammographic breast density during six months treatment. Digitized assessment also yields data on individual variation and small increases left undetectable by visual classification.

Authors+Show Affiliations

Department of Women's and Children's Health, Karolinska Institutet and University Hospital, Stockholm, Sweden. eva.lundstrom@karolinska.seNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21958943

Citation

Lundström, E, et al. "Digitized Assessment of Mammographic Breast Density--effects of Continuous Combined Hormone Therapy, Tibolone and Black Cohosh Compared to Placebo." Maturitas, vol. 70, no. 4, 2011, pp. 361-4.
Lundström E, Hirschberg AL, Söderqvist G. Digitized assessment of mammographic breast density--effects of continuous combined hormone therapy, tibolone and black cohosh compared to placebo. Maturitas. 2011;70(4):361-4.
Lundström, E., Hirschberg, A. L., & Söderqvist, G. (2011). Digitized assessment of mammographic breast density--effects of continuous combined hormone therapy, tibolone and black cohosh compared to placebo. Maturitas, 70(4), 361-4. https://doi.org/10.1016/j.maturitas.2011.08.009
Lundström E, Hirschberg AL, Söderqvist G. Digitized Assessment of Mammographic Breast Density--effects of Continuous Combined Hormone Therapy, Tibolone and Black Cohosh Compared to Placebo. Maturitas. 2011;70(4):361-4. PubMed PMID: 21958943.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Digitized assessment of mammographic breast density--effects of continuous combined hormone therapy, tibolone and black cohosh compared to placebo. AU - Lundström,E, AU - Hirschberg,A L, AU - Söderqvist,G, Y1 - 2011/09/29/ PY - 2011/03/16/received PY - 2011/08/24/revised PY - 2011/08/30/accepted PY - 2011/10/1/entrez PY - 2011/10/1/pubmed PY - 2012/3/31/medline SP - 361 EP - 4 JF - Maturitas JO - Maturitas VL - 70 IS - 4 N2 - OBJECTIVES: To determine the effects of continuous combined hormone therapy, tibolone, black cohosh, and placebo on digitized mammographic breast density in postmenopausal women. STUDY DESIGN: A prospective, double-blind, placebo-controlled study of 154 postmenopausal women randomized to estradiol 2 mg/norethisterone acetate 1 mg (E2/NETA), tibolone 2.5 mg or placebo and a prospective, open, uncontrolled drug safety study, of which 65 postmenopausal women were treated with black cohosh. Mammograms, at baseline and after six months of treatment, were previously classified according to visual quantification scales. MAIN OUTCOME MEASURES: Reanalysis of assessable mammograms by digitized quantification of breast density. RESULTS: Treatment groups were comparable at baseline. During treatment, both E2/NETA and tibolone significantly increased breast density (mean increase 14.3%, p<0.001 and 2.3%, p<0.001, respectively), while black cohosh and placebo did not. Twenty-four out of the 43 women on E2/NETA had an increase in density exceeding 10% and 6 women had an increase of 30% or more. In the tibolone group, only one woman had an increase in density of more than 10%. The difference in increase in breast density between E2/NETA on the one hand and tibolone, black cohosh and placebo on the other was highly significant (p<0.0001). CONCLUSIONS: Digitized mammographic breast density is a highly sensitive method confirming significant increase in density by standard E2/NETA treatment and to a lesser extent by tibolone, whereas black cohosh does not influence mammographic breast density during six months treatment. Digitized assessment also yields data on individual variation and small increases left undetectable by visual classification. SN - 1873-4111 UR - https://www.unboundmedicine.com/medline/citation/21958943/Digitized_assessment_of_mammographic_breast_density__effects_of_continuous_combined_hormone_therapy_tibolone_and_black_cohosh_compared_to_placebo_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5122(11)00318-5 DB - PRIME DP - Unbound Medicine ER -