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Impact of the look AHEAD intervention on NT-pro brain natriuretic peptide in overweight and obese adults with diabetes.
Obesity (Silver Spring) 2012; 20(7):1511-8O

Abstract

Look AHEAD (Action for Health in Diabetes) is a randomized trial determining whether intensive lifestyle intervention (ILI) aimed at long-term weight loss and increased physical fitness reduces cardiovascular morbidity and mortality in overweight and obese individuals with type 2 diabetes compared to control (diabetes support and education, DSE). We investigated the correlates of N-terminal pro-brain natriuretic peptide (NT-proBNP), a biomarker associated with heart failure (HF) risk, in a subsample from 15 of 16 participating centers and tested the hypothesis that ILI decreased NT-proBNP levels. Baseline and 1-year blood samples were assayed for NT-proBNP in a random sample of 1,500 without, and all 628 with, self-reported baseline CVD (cardiovascular disease) (N = 2,128). Linear models were used to assess relationships that log-transformed NT-proBNP had with CVD risk factors at baseline and that 1-year changes in NT-proBNP had with intervention assignment. At baseline, the mean (s.d.) age, BMI, and hemoglobin A(1c) (HbA(1c)) were 59.6 (6.8) years, 36.0 kg/m(2) (5.8), and 7.2% (1.1), respectively. Baseline geometric mean NT-proBNP was not different by condition (ILI 53.3 vs. DSE 51.5, P = 0.45), was not associated with BMI, and was inversely associated with HbA(1c). At 1 year, ILI participants achieved an average weight loss of 8.3% compared to 0.7% in DSE. At 1 year, NT-proBNP levels increased to a greater extent in the intervention arm (ILI +21.3% vs. DSE +14.2%, P = 0.046). The increased NT-proBNP associated with ILI was correlated with changes in HbA(1c), BMI, and body composition. In conclusion, among overweight and obese persons with diabetes, an ILI that reduced weight was associated with an increased NT-proBNP.

Authors+Show Affiliations

Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC, USA. abertoni@wakehealth.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21959345

Citation

Bertoni, Alain G., et al. "Impact of the Look AHEAD Intervention On NT-pro Brain Natriuretic Peptide in Overweight and Obese Adults With Diabetes." Obesity (Silver Spring, Md.), vol. 20, no. 7, 2012, pp. 1511-8.
Bertoni AG, Wagenknecht LE, Kitzman DW, et al. Impact of the look AHEAD intervention on NT-pro brain natriuretic peptide in overweight and obese adults with diabetes. Obesity (Silver Spring). 2012;20(7):1511-8.
Bertoni, A. G., Wagenknecht, L. E., Kitzman, D. W., Marcovina, S. M., Rushing, J. T., & Espeland, M. A. (2012). Impact of the look AHEAD intervention on NT-pro brain natriuretic peptide in overweight and obese adults with diabetes. Obesity (Silver Spring, Md.), 20(7), pp. 1511-8. doi:10.1038/oby.2011.296.
Bertoni AG, et al. Impact of the Look AHEAD Intervention On NT-pro Brain Natriuretic Peptide in Overweight and Obese Adults With Diabetes. Obesity (Silver Spring). 2012;20(7):1511-8. PubMed PMID: 21959345.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of the look AHEAD intervention on NT-pro brain natriuretic peptide in overweight and obese adults with diabetes. AU - Bertoni,Alain G, AU - Wagenknecht,Lynne E, AU - Kitzman,Dalane W, AU - Marcovina,Santica M, AU - Rushing,Julia T, AU - Espeland,Mark A, AU - ,, Y1 - 2011/09/29/ PY - 2011/10/1/entrez PY - 2011/10/1/pubmed PY - 2012/10/18/medline SP - 1511 EP - 8 JF - Obesity (Silver Spring, Md.) JO - Obesity (Silver Spring) VL - 20 IS - 7 N2 - Look AHEAD (Action for Health in Diabetes) is a randomized trial determining whether intensive lifestyle intervention (ILI) aimed at long-term weight loss and increased physical fitness reduces cardiovascular morbidity and mortality in overweight and obese individuals with type 2 diabetes compared to control (diabetes support and education, DSE). We investigated the correlates of N-terminal pro-brain natriuretic peptide (NT-proBNP), a biomarker associated with heart failure (HF) risk, in a subsample from 15 of 16 participating centers and tested the hypothesis that ILI decreased NT-proBNP levels. Baseline and 1-year blood samples were assayed for NT-proBNP in a random sample of 1,500 without, and all 628 with, self-reported baseline CVD (cardiovascular disease) (N = 2,128). Linear models were used to assess relationships that log-transformed NT-proBNP had with CVD risk factors at baseline and that 1-year changes in NT-proBNP had with intervention assignment. At baseline, the mean (s.d.) age, BMI, and hemoglobin A(1c) (HbA(1c)) were 59.6 (6.8) years, 36.0 kg/m(2) (5.8), and 7.2% (1.1), respectively. Baseline geometric mean NT-proBNP was not different by condition (ILI 53.3 vs. DSE 51.5, P = 0.45), was not associated with BMI, and was inversely associated with HbA(1c). At 1 year, ILI participants achieved an average weight loss of 8.3% compared to 0.7% in DSE. At 1 year, NT-proBNP levels increased to a greater extent in the intervention arm (ILI +21.3% vs. DSE +14.2%, P = 0.046). The increased NT-proBNP associated with ILI was correlated with changes in HbA(1c), BMI, and body composition. In conclusion, among overweight and obese persons with diabetes, an ILI that reduced weight was associated with an increased NT-proBNP. SN - 1930-739X UR - https://www.unboundmedicine.com/medline/citation/21959345/Impact_of_the_look_AHEAD_intervention_on_NT_pro_brain_natriuretic_peptide_in_overweight_and_obese_adults_with_diabetes_ L2 - https://doi.org/10.1038/oby.2011.296 DB - PRIME DP - Unbound Medicine ER -