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Preparation and in-vitro in-vivo evaluation of sustained release matrix diclofenac sodium tablets using PVP-K90 and natural gums.
Pak J Pharm Sci. 2011 Oct; 24(4):435-43.PJ

Abstract

Conventional dosage form is nowadays mostly replaced by sustained release formulation in order to increase drug efficacy and patient compliance. The sustained release properties of the PVP K90 alone and in combination with guar gum, xanthan gum and gum tragacanth were evaluated using diclofenac sodium (100 mg/tablet) as a model drug. Tablets were processed using wet granulation method and evaluated for sustained drug release properties. The drug release from the formulations was studied in relationship with Commercially available Diclofenac Sodium SR, used as a reference tablets and results were expressed as similarity (f1) and differential factor (f2). The tablets prepared using PVP K90 160 mg/tablet sustained the release of diclofenac sodium for 12 hours. Formulations where the PVP K90 was partially replaced with different gums also sustained the release of drug for 12 hours. The release of the drug from these formulations mainly followed Higuchi model and super case-II and Non-Fickian diffusion. The in-vivo drug release was studied in healthy human volunteers using non-blinded cross over, two period design using Diclofenac Sodium SR Tablets as a reference drug. The relative bioavailability of the formulation containing PVP K90 and gum tragacanth was 0.91. The studies showed that the use of the PVP K90 in combination with gum tragacanth both in-vitro and in-vivo sustained the release of the drug.

Authors+Show Affiliations

Department of Pharmacy, University of Peshawar, Peshawar, Pakistan. zafar_iqbal@upesh.edu.pkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21959802

Citation

Iqbal, Zafar, et al. "Preparation and In-vitro In-vivo Evaluation of Sustained Release Matrix Diclofenac Sodium Tablets Using PVP-K90 and Natural Gums." Pakistan Journal of Pharmaceutical Sciences, vol. 24, no. 4, 2011, pp. 435-43.
Iqbal Z, Khan R, Nasir F, et al. Preparation and in-vitro in-vivo evaluation of sustained release matrix diclofenac sodium tablets using PVP-K90 and natural gums. Pak J Pharm Sci. 2011;24(4):435-43.
Iqbal, Z., Khan, R., Nasir, F., Khan, J. A., Rashid, A., Khan, A., & Khan, A. (2011). Preparation and in-vitro in-vivo evaluation of sustained release matrix diclofenac sodium tablets using PVP-K90 and natural gums. Pakistan Journal of Pharmaceutical Sciences, 24(4), 435-43.
Iqbal Z, et al. Preparation and In-vitro In-vivo Evaluation of Sustained Release Matrix Diclofenac Sodium Tablets Using PVP-K90 and Natural Gums. Pak J Pharm Sci. 2011;24(4):435-43. PubMed PMID: 21959802.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preparation and in-vitro in-vivo evaluation of sustained release matrix diclofenac sodium tablets using PVP-K90 and natural gums. AU - Iqbal,Zafar, AU - Khan,Raza, AU - Nasir,Fazli, AU - Khan,Jamshaid Ali, AU - Rashid,Abdur, AU - Khan,Abbas, AU - Khan,Abad, PY - 2011/10/1/entrez PY - 2011/10/1/pubmed PY - 2012/3/3/medline SP - 435 EP - 43 JF - Pakistan journal of pharmaceutical sciences JO - Pak J Pharm Sci VL - 24 IS - 4 N2 - Conventional dosage form is nowadays mostly replaced by sustained release formulation in order to increase drug efficacy and patient compliance. The sustained release properties of the PVP K90 alone and in combination with guar gum, xanthan gum and gum tragacanth were evaluated using diclofenac sodium (100 mg/tablet) as a model drug. Tablets were processed using wet granulation method and evaluated for sustained drug release properties. The drug release from the formulations was studied in relationship with Commercially available Diclofenac Sodium SR, used as a reference tablets and results were expressed as similarity (f1) and differential factor (f2). The tablets prepared using PVP K90 160 mg/tablet sustained the release of diclofenac sodium for 12 hours. Formulations where the PVP K90 was partially replaced with different gums also sustained the release of drug for 12 hours. The release of the drug from these formulations mainly followed Higuchi model and super case-II and Non-Fickian diffusion. The in-vivo drug release was studied in healthy human volunteers using non-blinded cross over, two period design using Diclofenac Sodium SR Tablets as a reference drug. The relative bioavailability of the formulation containing PVP K90 and gum tragacanth was 0.91. The studies showed that the use of the PVP K90 in combination with gum tragacanth both in-vitro and in-vivo sustained the release of the drug. SN - 1011-601X UR - https://www.unboundmedicine.com/medline/citation/21959802/Preparation_and_in_vitro_in_vivo_evaluation_of_sustained_release_matrix_diclofenac_sodium_tablets_using_PVP_K90_and_natural_gums_ L2 - https://antibodies.cancer.gov/detail/CPTC-SNCG-3 DB - PRIME DP - Unbound Medicine ER -