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Acute tolerance to alcohol impairment of behavioral and cognitive mechanisms related to driving: drinking and driving on the descending limb.
Psychopharmacology (Berl). 2012 Apr; 220(4):697-706.P

Abstract

RATIONALE

Alcohol effects on behavioral and cognitive mechanisms influence impaired driving performance and decisions to drive after drinking (Barry 1973; Moskowitz and Robinson 1987). To date, research has focused on the ascending limb of the blood alcohol curve, and there is little understanding of how acute tolerance to impairment of these mechanisms might influence driving behavior on the descending limb.

OBJECTIVES

To provide an integrated examination of the degree to which alcohol impairment of motor coordination and inhibitory control contributes to driving impairment and decisions to drive on the ascending and descending limbs of the blood alcohol curve.

METHODS

Social-drinking adults (N = 20) performed a testing battery that measured simulated driving performance and willingness to drive, as well as mechanisms related to driving: motor coordination (grooved pegboard), inhibitory control (cued go/no-go task), and subjective intoxication. Performance was tested in response to placebo and a moderate dose of alcohol (0.65 g/kg) twice at comparable blood alcohol concentrations: once on the ascending limb and again on the descending limb.

RESULTS

Impaired motor coordination and subjective intoxication showed acute tolerance, whereas driving performance and inhibitory control showed no recovery from impairment. Greater motor impairment was associated with poorer driving performance under alcohol, and poorer inhibitory control was associated with more willingness to drive.

CONCLUSIONS

Findings suggest that acute tolerance to impairment of motor coordination is insufficient to promote recovery of driving performance and that the persistence of alcohol-induced disinhibition might contribute to risky decisions to drive on the descending limb.

Authors+Show Affiliations

Department of Psychology, University of Kentucky, Kastle Hall, Lexington, KY 40506-0044, USA.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

21960182

Citation

Weafer, Jessica, and Mark T. Fillmore. "Acute Tolerance to Alcohol Impairment of Behavioral and Cognitive Mechanisms Related to Driving: Drinking and Driving On the Descending Limb." Psychopharmacology, vol. 220, no. 4, 2012, pp. 697-706.
Weafer J, Fillmore MT. Acute tolerance to alcohol impairment of behavioral and cognitive mechanisms related to driving: drinking and driving on the descending limb. Psychopharmacology (Berl). 2012;220(4):697-706.
Weafer, J., & Fillmore, M. T. (2012). Acute tolerance to alcohol impairment of behavioral and cognitive mechanisms related to driving: drinking and driving on the descending limb. Psychopharmacology, 220(4), 697-706. https://doi.org/10.1007/s00213-011-2519-6
Weafer J, Fillmore MT. Acute Tolerance to Alcohol Impairment of Behavioral and Cognitive Mechanisms Related to Driving: Drinking and Driving On the Descending Limb. Psychopharmacology (Berl). 2012;220(4):697-706. PubMed PMID: 21960182.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute tolerance to alcohol impairment of behavioral and cognitive mechanisms related to driving: drinking and driving on the descending limb. AU - Weafer,Jessica, AU - Fillmore,Mark T, Y1 - 2011/09/30/ PY - 2011/06/14/received PY - 2011/09/19/accepted PY - 2011/10/1/entrez PY - 2011/10/1/pubmed PY - 2012/12/27/medline SP - 697 EP - 706 JF - Psychopharmacology JO - Psychopharmacology (Berl.) VL - 220 IS - 4 N2 - RATIONALE: Alcohol effects on behavioral and cognitive mechanisms influence impaired driving performance and decisions to drive after drinking (Barry 1973; Moskowitz and Robinson 1987). To date, research has focused on the ascending limb of the blood alcohol curve, and there is little understanding of how acute tolerance to impairment of these mechanisms might influence driving behavior on the descending limb. OBJECTIVES: To provide an integrated examination of the degree to which alcohol impairment of motor coordination and inhibitory control contributes to driving impairment and decisions to drive on the ascending and descending limbs of the blood alcohol curve. METHODS: Social-drinking adults (N = 20) performed a testing battery that measured simulated driving performance and willingness to drive, as well as mechanisms related to driving: motor coordination (grooved pegboard), inhibitory control (cued go/no-go task), and subjective intoxication. Performance was tested in response to placebo and a moderate dose of alcohol (0.65 g/kg) twice at comparable blood alcohol concentrations: once on the ascending limb and again on the descending limb. RESULTS: Impaired motor coordination and subjective intoxication showed acute tolerance, whereas driving performance and inhibitory control showed no recovery from impairment. Greater motor impairment was associated with poorer driving performance under alcohol, and poorer inhibitory control was associated with more willingness to drive. CONCLUSIONS: Findings suggest that acute tolerance to impairment of motor coordination is insufficient to promote recovery of driving performance and that the persistence of alcohol-induced disinhibition might contribute to risky decisions to drive on the descending limb. SN - 1432-2072 UR - https://www.unboundmedicine.com/medline/citation/21960182/Acute_tolerance_to_alcohol_impairment_of_behavioral_and_cognitive_mechanisms_related_to_driving:_drinking_and_driving_on_the_descending_limb_ L2 - https://dx.doi.org/10.1007/s00213-011-2519-6 DB - PRIME DP - Unbound Medicine ER -