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Acromegaly due to an ectopic pituitary adenoma in the clivus: case report and review of literature.
Pituitary. 2012 Dec; 15 Suppl 1:S53-6.P

Abstract

Pituitary adenomas rarely originate outside the sella turcica. Ectopic locations include the suprasellar region, sphenoid sinus, cavernous sinus and clivus. We describe a 50-year-old female who presented with clinical signs and biochemical evidence of acromegaly. Pituitary MRI demonstrated a 2 mm hypointense lesion on the right side of the pituitary gland. However upon drilling of the upper clival bone to expose the sella during endoscopic transsphenoidal surgery, soft tumor-like tissue was encountered within the clivus. Exploration of the sella, including the area of hypointensity noted on preoperative imaging, did not identify any other abnormality. Immunohistochemical examination of the fully resected tumor demonstrated growth hormone immunoreactivity. Failed preoperative diagnosis of this rare ectopic GH-producing tumor was compounded by the presence of a misleading pituitary abnormality consistent with a microadenoma. The epidemiology and pertinent literature of this uncommon condition is discussed.

Authors+Show Affiliations

Department of Medicine, David Geffen School of Medicine at UCLA, 9-240 N Factor Building, Los Angeles, CA 90095, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

21960210

Citation

Appel, Julia Goulart, et al. "Acromegaly Due to an Ectopic Pituitary Adenoma in the Clivus: Case Report and Review of Literature." Pituitary, vol. 15 Suppl 1, 2012, pp. S53-6.
Appel JG, Bergsneider M, Vinters H, et al. Acromegaly due to an ectopic pituitary adenoma in the clivus: case report and review of literature. Pituitary. 2012;15 Suppl 1:S53-6.
Appel, J. G., Bergsneider, M., Vinters, H., Salamon, N., Wang, M. B., & Heaney, A. P. (2012). Acromegaly due to an ectopic pituitary adenoma in the clivus: case report and review of literature. Pituitary, 15 Suppl 1, S53-6. https://doi.org/10.1007/s11102-011-0345-9
Appel JG, et al. Acromegaly Due to an Ectopic Pituitary Adenoma in the Clivus: Case Report and Review of Literature. Pituitary. 2012;15 Suppl 1:S53-6. PubMed PMID: 21960210.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acromegaly due to an ectopic pituitary adenoma in the clivus: case report and review of literature. AU - Appel,Julia Goulart, AU - Bergsneider,Marvin, AU - Vinters,Harry, AU - Salamon,Noriko, AU - Wang,Marilene B, AU - Heaney,Anthony P, PY - 2011/10/1/entrez PY - 2011/10/1/pubmed PY - 2013/5/8/medline SP - S53 EP - 6 JF - Pituitary JO - Pituitary VL - 15 Suppl 1 N2 - Pituitary adenomas rarely originate outside the sella turcica. Ectopic locations include the suprasellar region, sphenoid sinus, cavernous sinus and clivus. We describe a 50-year-old female who presented with clinical signs and biochemical evidence of acromegaly. Pituitary MRI demonstrated a 2 mm hypointense lesion on the right side of the pituitary gland. However upon drilling of the upper clival bone to expose the sella during endoscopic transsphenoidal surgery, soft tumor-like tissue was encountered within the clivus. Exploration of the sella, including the area of hypointensity noted on preoperative imaging, did not identify any other abnormality. Immunohistochemical examination of the fully resected tumor demonstrated growth hormone immunoreactivity. Failed preoperative diagnosis of this rare ectopic GH-producing tumor was compounded by the presence of a misleading pituitary abnormality consistent with a microadenoma. The epidemiology and pertinent literature of this uncommon condition is discussed. SN - 1573-7403 UR - https://www.unboundmedicine.com/medline/citation/21960210/Acromegaly_due_to_an_ectopic_pituitary_adenoma_in_the_clivus:_case_report_and_review_of_literature_ L2 - https://doi.org/10.1007/s11102-011-0345-9 DB - PRIME DP - Unbound Medicine ER -