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Vegetables and fruits consumption and risk of esophageal and gastric cancer subtypes in the Netherlands Cohort Study.

Abstract

Prospective epidemiologic data on vegetables and fruits consumption and risk of subtypes of esophageal and gastric cancer are sparse. We studied the association between vegetables and fruits consumption and risk of esophageal squamous cell carcinoma (ESCC), esophageal adenocarcinoma (EAC), gastric cardia adenocarcinoma (GCA) and gastric noncardia adenocarcinoma (GNCA) in the Netherlands Cohort Study. In 1986, 120,852 Dutch men and women aged 55-69 filled out a questionnaire on diet and other cancer risk factors. After 16.3 years of follow-up, 101 ESCC, 144 EAC, 156 GCA, 460 GNCA cases and 4,035 subcohort members were available for case-cohort analysis using Cox proportional hazards models. Multivariable adjusted incidence rate ratios (RRs) were generally below unity. Total vegetable consumption was nonsignificantly inversely associated with EAC and ESCC risk, but not with GCA and GNCA risk. Significant inverse associations were observed for raw vegetables and EAC risk [RR per 25 g/day: 0.81, 95% confidence interval (CI) 0.68-0.98], and Brassica vegetables and GCA risk (RR per 25 g/day: 0.72, 95% CI 0.54-0.95). Total fruit consumption was associated with a nonsignificantly decreased EAC risk. Citrus fruits were inversely associated with EAC and GCA risk (RRs for highest vs. lowest intake: 0.55, 95% CI 0.31-0.98 and 0.38, 95% CI 0.21-0.69, respectively). Specifically for current smokers, vegetables and possibly also fruits intake was inversely associated with ESCC and EAC risk. Consumption of (specific groups of) vegetables and fruits may protect against subtypes of esophageal and gastric cancer.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Centre +, Maastricht, The Netherlands.

    , ,

    Source

    International journal of cancer 129:11 2011 Dec 01 pg 2681-93

    MeSH

    Adenocarcinoma
    Aged
    Carcinoma, Squamous Cell
    Cardia
    Cohort Studies
    Esophageal Neoplasms
    Female
    Follow-Up Studies
    Fruit
    Humans
    Male
    Middle Aged
    Prognosis
    Prospective Studies
    Risk Factors
    Stomach Neoplasms
    Survival Rate
    Vegetables

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21960262

    Citation

    Steevens, Jessie, et al. "Vegetables and Fruits Consumption and Risk of Esophageal and Gastric Cancer Subtypes in the Netherlands Cohort Study." International Journal of Cancer, vol. 129, no. 11, 2011, pp. 2681-93.
    Steevens J, Schouten LJ, Goldbohm RA, et al. Vegetables and fruits consumption and risk of esophageal and gastric cancer subtypes in the Netherlands Cohort Study. Int J Cancer. 2011;129(11):2681-93.
    Steevens, J., Schouten, L. J., Goldbohm, R. A., & van den Brandt, P. A. (2011). Vegetables and fruits consumption and risk of esophageal and gastric cancer subtypes in the Netherlands Cohort Study. International Journal of Cancer, 129(11), pp. 2681-93. doi:10.1002/ijc.25928.
    Steevens J, et al. Vegetables and Fruits Consumption and Risk of Esophageal and Gastric Cancer Subtypes in the Netherlands Cohort Study. Int J Cancer. 2011 Dec 1;129(11):2681-93. PubMed PMID: 21960262.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Vegetables and fruits consumption and risk of esophageal and gastric cancer subtypes in the Netherlands Cohort Study. AU - Steevens,Jessie, AU - Schouten,Leo J, AU - Goldbohm,R Alexandra, AU - van den Brandt,Piet A, Y1 - 2011/08/24/ PY - 2010/10/24/received PY - 2010/12/20/accepted PY - 2011/10/1/entrez PY - 2011/10/1/pubmed PY - 2011/12/13/medline SP - 2681 EP - 93 JF - International journal of cancer JO - Int. J. Cancer VL - 129 IS - 11 N2 - Prospective epidemiologic data on vegetables and fruits consumption and risk of subtypes of esophageal and gastric cancer are sparse. We studied the association between vegetables and fruits consumption and risk of esophageal squamous cell carcinoma (ESCC), esophageal adenocarcinoma (EAC), gastric cardia adenocarcinoma (GCA) and gastric noncardia adenocarcinoma (GNCA) in the Netherlands Cohort Study. In 1986, 120,852 Dutch men and women aged 55-69 filled out a questionnaire on diet and other cancer risk factors. After 16.3 years of follow-up, 101 ESCC, 144 EAC, 156 GCA, 460 GNCA cases and 4,035 subcohort members were available for case-cohort analysis using Cox proportional hazards models. Multivariable adjusted incidence rate ratios (RRs) were generally below unity. Total vegetable consumption was nonsignificantly inversely associated with EAC and ESCC risk, but not with GCA and GNCA risk. Significant inverse associations were observed for raw vegetables and EAC risk [RR per 25 g/day: 0.81, 95% confidence interval (CI) 0.68-0.98], and Brassica vegetables and GCA risk (RR per 25 g/day: 0.72, 95% CI 0.54-0.95). Total fruit consumption was associated with a nonsignificantly decreased EAC risk. Citrus fruits were inversely associated with EAC and GCA risk (RRs for highest vs. lowest intake: 0.55, 95% CI 0.31-0.98 and 0.38, 95% CI 0.21-0.69, respectively). Specifically for current smokers, vegetables and possibly also fruits intake was inversely associated with ESCC and EAC risk. Consumption of (specific groups of) vegetables and fruits may protect against subtypes of esophageal and gastric cancer. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/21960262/Vegetables_and_fruits_consumption_and_risk_of_esophageal_and_gastric_cancer_subtypes_in_the_Netherlands_Cohort_Study_ L2 - https://doi.org/10.1002/ijc.25928 DB - PRIME DP - Unbound Medicine ER -