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Antiproliferative activity of xanthones isolated from Artocarpus obtusus.
J Biomed Biotechnol. 2012; 2012:130627.JB

Abstract

An investigation of the chemical constituents in Artocarpus obtusus species led to the isolation of three new xanthones, pyranocycloartobiloxanthone A (1), dihydroartoindonesianin C (2), and pyranocycloartobiloxanthone B (3). The compounds were subjected to antiproliferative assay against human promyelocytic leukemia (HL60), human chronic myeloid leukemia (K562), and human estrogen receptor (ER+) positive breast cancer (MCF7) cell lines. Pyranocycloartobiloxanthone A (1) consistently showed strong cytotoxic activity against the three cell lines compared to the other two with IC(50) values of 0.5, 2.0 and 5.0 μg/mL, respectively. Compound (1) was also observed to exert antiproliferative activity and apoptotic promoter towards HL60 and MCF7 cell lines at respective IC(50) values. The compound (1) was not toxic towards normal cell lines human nontumorigenic breast cell line (MCF10A) and human peripheral blood mononuclear cells (PBMCs) with IC(50) values of more than 30 μg/mL.

Authors+Show Affiliations

Department of Chemistry, Universiti Putra Malaysia, Selangor, 43400 Serdang, Malaysia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21960741

Citation

Hashim, Najihah Mohd, et al. "Antiproliferative Activity of Xanthones Isolated From Artocarpus Obtusus." Journal of Biomedicine & Biotechnology, vol. 2012, 2012, p. 130627.
Hashim NM, Rahmani M, Ee GC, et al. Antiproliferative activity of xanthones isolated from Artocarpus obtusus. J Biomed Biotechnol. 2012;2012:130627.
Hashim, N. M., Rahmani, M., Ee, G. C., Sukari, M. A., Yahayu, M., Oktima, W., Ali, A. M., & Go, R. (2012). Antiproliferative activity of xanthones isolated from Artocarpus obtusus. Journal of Biomedicine & Biotechnology, 2012, 130627. https://doi.org/10.1155/2012/130627
Hashim NM, et al. Antiproliferative Activity of Xanthones Isolated From Artocarpus Obtusus. J Biomed Biotechnol. 2012;2012:130627. PubMed PMID: 21960741.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antiproliferative activity of xanthones isolated from Artocarpus obtusus. AU - Hashim,Najihah Mohd, AU - Rahmani,Mawardi, AU - Ee,Gwendoline Cheng Lian, AU - Sukari,Mohd Aspollah, AU - Yahayu,Maizatulakmal, AU - Oktima,Winda, AU - Ali,Abd Manaf, AU - Go,Rusea, Y1 - 2011/09/22/ PY - 2011/06/17/received PY - 2011/07/15/revised PY - 2011/07/16/accepted PY - 2011/10/1/entrez PY - 2011/10/1/pubmed PY - 2012/2/4/medline SP - 130627 EP - 130627 JF - Journal of biomedicine & biotechnology JO - J Biomed Biotechnol VL - 2012 N2 - An investigation of the chemical constituents in Artocarpus obtusus species led to the isolation of three new xanthones, pyranocycloartobiloxanthone A (1), dihydroartoindonesianin C (2), and pyranocycloartobiloxanthone B (3). The compounds were subjected to antiproliferative assay against human promyelocytic leukemia (HL60), human chronic myeloid leukemia (K562), and human estrogen receptor (ER+) positive breast cancer (MCF7) cell lines. Pyranocycloartobiloxanthone A (1) consistently showed strong cytotoxic activity against the three cell lines compared to the other two with IC(50) values of 0.5, 2.0 and 5.0 μg/mL, respectively. Compound (1) was also observed to exert antiproliferative activity and apoptotic promoter towards HL60 and MCF7 cell lines at respective IC(50) values. The compound (1) was not toxic towards normal cell lines human nontumorigenic breast cell line (MCF10A) and human peripheral blood mononuclear cells (PBMCs) with IC(50) values of more than 30 μg/mL. SN - 1110-7251 UR - https://www.unboundmedicine.com/medline/citation/21960741/Antiproliferative_activity_of_xanthones_isolated_from_Artocarpus_obtusus_ L2 - https://doi.org/10.1155/2012/130627 DB - PRIME DP - Unbound Medicine ER -