Tags

Type your tag names separated by a space and hit enter

Influence of family history as a risk factor on primary angle closure and primary open angle glaucoma in a Chinese population.
Ophthalmic Epidemiol 2011; 18(5):226-32OE

Abstract

PURPOSE

To identify the likelihood of family history as a risk factor for the presence and severity of primary angle closure (PAC) and primary open angle glaucoma (POAG) in a Chinese population.

METHODS

All participants were asked to complete a questionnaire and undergo a comprehensive eye examination. Past history of hypertension, diabetes mellitus, hyperopia, high myopia, and family history of glaucoma were recorded. For those patients with a family history of glaucoma, the relationship between the patient and the affected relatives has been specified.

RESULTS

A total of 332 PAC patients, 228 POAG patients and 193 controls were included. Of the 332 PAC patients, 83 (25.00%) had glaucoma family history. Characteristic-adjusted odds ratio (OR) of family history for PAC was 4.82 [95% confidence interval (CI): 2.08-11.19] and for severity of PAC was 1.61 (95% CI: 1.05-2.49). Among first-relatives only parents account for the family history rate of PAC [OR 8.76 (95% CI: 2.00-38.32)]. Of the 228 POAG patients, 49 (21.49%) had a family history of glaucoma. Odds ratio for POAG was 8.38 (95% CI: 3.33-21.07) and for severity of POAG was 1.81 (95% CI: 1.05-3.14). Unlike patients with PAC, only siblings and offspring account for the family history rate of POAG [OR 8.99 (95% CI: 2.38-33.99) and OR 19.23 (95% CI: 1.53-241.24) respectively].

CONCLUSION

Our study showed that a family history of glaucoma is associated with the presence and severity of PAC and POAG. This supports the finding that screening first-degree relatives will be an effective way to detect glaucoma in a population.

Authors+Show Affiliations

Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21961512

Citation

Kong, Xiangmei, et al. "Influence of Family History as a Risk Factor On Primary Angle Closure and Primary Open Angle Glaucoma in a Chinese Population." Ophthalmic Epidemiology, vol. 18, no. 5, 2011, pp. 226-32.
Kong X, Chen Y, Chen X, et al. Influence of family history as a risk factor on primary angle closure and primary open angle glaucoma in a Chinese population. Ophthalmic Epidemiol. 2011;18(5):226-32.
Kong, X., Chen, Y., Chen, X., & Sun, X. (2011). Influence of family history as a risk factor on primary angle closure and primary open angle glaucoma in a Chinese population. Ophthalmic Epidemiology, 18(5), pp. 226-32. doi:10.3109/09286586.2011.595040.
Kong X, et al. Influence of Family History as a Risk Factor On Primary Angle Closure and Primary Open Angle Glaucoma in a Chinese Population. Ophthalmic Epidemiol. 2011;18(5):226-32. PubMed PMID: 21961512.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of family history as a risk factor on primary angle closure and primary open angle glaucoma in a Chinese population. AU - Kong,Xiangmei, AU - Chen,Yuhong, AU - Chen,Xueli, AU - Sun,Xinghuai, PY - 2011/10/4/entrez PY - 2011/10/4/pubmed PY - 2011/12/21/medline SP - 226 EP - 32 JF - Ophthalmic epidemiology JO - Ophthalmic Epidemiol VL - 18 IS - 5 N2 - PURPOSE: To identify the likelihood of family history as a risk factor for the presence and severity of primary angle closure (PAC) and primary open angle glaucoma (POAG) in a Chinese population. METHODS: All participants were asked to complete a questionnaire and undergo a comprehensive eye examination. Past history of hypertension, diabetes mellitus, hyperopia, high myopia, and family history of glaucoma were recorded. For those patients with a family history of glaucoma, the relationship between the patient and the affected relatives has been specified. RESULTS: A total of 332 PAC patients, 228 POAG patients and 193 controls were included. Of the 332 PAC patients, 83 (25.00%) had glaucoma family history. Characteristic-adjusted odds ratio (OR) of family history for PAC was 4.82 [95% confidence interval (CI): 2.08-11.19] and for severity of PAC was 1.61 (95% CI: 1.05-2.49). Among first-relatives only parents account for the family history rate of PAC [OR 8.76 (95% CI: 2.00-38.32)]. Of the 228 POAG patients, 49 (21.49%) had a family history of glaucoma. Odds ratio for POAG was 8.38 (95% CI: 3.33-21.07) and for severity of POAG was 1.81 (95% CI: 1.05-3.14). Unlike patients with PAC, only siblings and offspring account for the family history rate of POAG [OR 8.99 (95% CI: 2.38-33.99) and OR 19.23 (95% CI: 1.53-241.24) respectively]. CONCLUSION: Our study showed that a family history of glaucoma is associated with the presence and severity of PAC and POAG. This supports the finding that screening first-degree relatives will be an effective way to detect glaucoma in a population. SN - 1744-5086 UR - https://www.unboundmedicine.com/medline/citation/21961512/Influence_of_family_history_as_a_risk_factor_on_primary_angle_closure_and_primary_open_angle_glaucoma_in_a_Chinese_population_ L2 - http://www.tandfonline.com/doi/full/10.3109/09286586.2011.595040 DB - PRIME DP - Unbound Medicine ER -