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Comparison of bronchodilator response in patients with asthma and healthy subjects using spirometry and oscillometry.
Ann Allergy Asthma Immunol. 2011 Oct; 107(4):317-22.AA

Abstract

BACKGROUND

Impulse oscillometry (IOS) is an effort-independent and patient-friendly pulmonary function technique, but limited data are available that correlate the bronchodilator response using spirometry and IOS in adult asthmatic and healthy subjects.

OBJECTIVE

To compare spirometry and IOS in ongoing bronchodilator response.

METHODS

The study was a prospective evaluation of patients with asthma and healthy subjects attending screening at a research unit in a university teaching hospital. Reversibility testing was carried out using standardized American Thoracic Society/European Respiratory Society (ATS/ERS) criteria after administering 400 μg salbutamol by AccuhalerTM. Impulse oscillometry measurements (resistance at 5 Hz [R5], resistance at 20 Hz [R20], reactance at 5 Hz [X5]) and spirometry (forced expiratory volume in 1 second [FEV(1)], forced vital capacity [FVC], forced expiratory flow from 25% to 75% of vital capacity [FEF(25-75)]) were recorded pre and postbronchodilator.

RESULTS

Ninety-five asthmatic and 61 healthy subjects underwent screening. Mean percent (standard error of the mean [SEM]) baseline prebronchodilator FEV(1) was 83.99 (2.23) for patients with asthma, and 99.25 (1.72) for healthy subjects. Baseline percent predicted IOS indices in the group with asthma were 162.22 (7.5) for R5; 154.73 (4.71) for R20; and 441.72 (173.86) for X5. In healthy volunteers, corresponding values were 111.01 (3.96), 127.75 (4.12), and -229.80 (125.75). R5 was the only IOS measure that showed correlation with spirometry (FEV(1)) in both groups. The mean percent (SEM) predicted postbronchodilator change in FEV(1) and R5 in patients with asthma was 6.35 (0.65) and -33.78 (4.43); correspondingly in healthy subjects it was 2.24 (0.32) and -14.91 (2.48). A negative correlation was demonstrated (r = -0.40, P < .001 between the 2 indices in patients with asthma. Linear regression modeling demonstrated that 1 unit change in %FEV(1) corresponds to a 2.5% change in %R5.

CONCLUSIONS

Low-frequency IOS as R5 and spirometry as FEV(1) correlate in patients with asthma and healthy subjects, with changes that can be predicted by linear regression.

Authors+Show Affiliations

Asthma & Allergy Research Unit, Centre for Cardiovascular & Lung Biology, Ninewells Hospital & Medical School, University of Dundee, Scotland, UK.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21962091

Citation

Nair, Arun, et al. "Comparison of Bronchodilator Response in Patients With Asthma and Healthy Subjects Using Spirometry and Oscillometry." Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, vol. 107, no. 4, 2011, pp. 317-22.
Nair A, Ward J, Lipworth BJ. Comparison of bronchodilator response in patients with asthma and healthy subjects using spirometry and oscillometry. Ann Allergy Asthma Immunol. 2011;107(4):317-22.
Nair, A., Ward, J., & Lipworth, B. J. (2011). Comparison of bronchodilator response in patients with asthma and healthy subjects using spirometry and oscillometry. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, 107(4), 317-22. https://doi.org/10.1016/j.anai.2011.07.011
Nair A, Ward J, Lipworth BJ. Comparison of Bronchodilator Response in Patients With Asthma and Healthy Subjects Using Spirometry and Oscillometry. Ann Allergy Asthma Immunol. 2011;107(4):317-22. PubMed PMID: 21962091.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of bronchodilator response in patients with asthma and healthy subjects using spirometry and oscillometry. AU - Nair,Arun, AU - Ward,Julia, AU - Lipworth,Brian J, PY - 2011/04/08/received PY - 2011/07/14/revised PY - 2011/07/20/accepted PY - 2011/10/4/entrez PY - 2011/10/4/pubmed PY - 2011/12/13/medline SP - 317 EP - 22 JF - Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology JO - Ann. Allergy Asthma Immunol. VL - 107 IS - 4 N2 - BACKGROUND: Impulse oscillometry (IOS) is an effort-independent and patient-friendly pulmonary function technique, but limited data are available that correlate the bronchodilator response using spirometry and IOS in adult asthmatic and healthy subjects. OBJECTIVE: To compare spirometry and IOS in ongoing bronchodilator response. METHODS: The study was a prospective evaluation of patients with asthma and healthy subjects attending screening at a research unit in a university teaching hospital. Reversibility testing was carried out using standardized American Thoracic Society/European Respiratory Society (ATS/ERS) criteria after administering 400 μg salbutamol by AccuhalerTM. Impulse oscillometry measurements (resistance at 5 Hz [R5], resistance at 20 Hz [R20], reactance at 5 Hz [X5]) and spirometry (forced expiratory volume in 1 second [FEV(1)], forced vital capacity [FVC], forced expiratory flow from 25% to 75% of vital capacity [FEF(25-75)]) were recorded pre and postbronchodilator. RESULTS: Ninety-five asthmatic and 61 healthy subjects underwent screening. Mean percent (standard error of the mean [SEM]) baseline prebronchodilator FEV(1) was 83.99 (2.23) for patients with asthma, and 99.25 (1.72) for healthy subjects. Baseline percent predicted IOS indices in the group with asthma were 162.22 (7.5) for R5; 154.73 (4.71) for R20; and 441.72 (173.86) for X5. In healthy volunteers, corresponding values were 111.01 (3.96), 127.75 (4.12), and -229.80 (125.75). R5 was the only IOS measure that showed correlation with spirometry (FEV(1)) in both groups. The mean percent (SEM) predicted postbronchodilator change in FEV(1) and R5 in patients with asthma was 6.35 (0.65) and -33.78 (4.43); correspondingly in healthy subjects it was 2.24 (0.32) and -14.91 (2.48). A negative correlation was demonstrated (r = -0.40, P < .001 between the 2 indices in patients with asthma. Linear regression modeling demonstrated that 1 unit change in %FEV(1) corresponds to a 2.5% change in %R5. CONCLUSIONS: Low-frequency IOS as R5 and spirometry as FEV(1) correlate in patients with asthma and healthy subjects, with changes that can be predicted by linear regression. SN - 1534-4436 UR - https://www.unboundmedicine.com/medline/citation/21962091/Comparison_of_bronchodilator_response_in_patients_with_asthma_and_healthy_subjects_using_spirometry_and_oscillometry_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1081-1206(11)00557-6 DB - PRIME DP - Unbound Medicine ER -