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In vitro antifungal susceptibility of Malassezia pachydermatis from dogs with and without skin lesions.
Vet Microbiol. 2012 Mar 23; 155(2-4):395-8.VM

Abstract

Canine Malassezia dermatitis is frequently treated with systemic ketoconazole (KTZ) and itraconazole (ITZ). However, no information is available on the antifungal susceptibility to azoles and allilamine of Malassezia pachydermatis isolates from dogs with or without skin lesions. The present study was designed to evaluate the in vitro antifungal susceptibility of M. pachydermatis strains from dogs with or without skin lesions to KTZ, ITZ, miconazole (MICO), fluconazole (FLZ), posaconazole (POS), voriconazole (VOR) and terbinafine (TER) using the Clinical and Laboratory Standards Institute reference Broth Microdilution Method (CLSI M27-A2). The association between the susceptibility to antifungal compounds and the origin of M. pachydermatis, from skin with or without lesions has been also assessed. A total of 62 M. pachydermatis strains from healthy dogs (i.e., Group A=30) or with skin lesions (i.e., Group B=32) were tested. ITZ, KTZ and POS showed the highest activity against M. pachydermatis strains, whereas MICO TER and FLZ the lowest. A higher number of Malassezia resistant strains were registered among isolates from Group B than those from Group A. This study indicates that M. pachydermatis strains were susceptible to ITZ, KTZ, and POS. However, dogs with lesions may harbour strains with low susceptibility to antifungal agents and displaying cross-resistance phenomena to azole. The antifungal therapy in Malassezia infections requires careful appraisal of choice of drugs especially in cases of unresponsiveness to antifungal treatment or recurrent infections.

Authors+Show Affiliations

Dipartimento di Sanità Pubblica e Zootecnia, Facoltà di Medicina Veterinaria, Università degli Studi di Bari, Str. prov.le per Casamassima Km 3, 70010 Valenzano, Bari, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21962411

Citation

Cafarchia, Claudia, et al. "In Vitro Antifungal Susceptibility of Malassezia Pachydermatis From Dogs With and Without Skin Lesions." Veterinary Microbiology, vol. 155, no. 2-4, 2012, pp. 395-8.
Cafarchia C, Figueredo LA, Iatta R, et al. In vitro antifungal susceptibility of Malassezia pachydermatis from dogs with and without skin lesions. Vet Microbiol. 2012;155(2-4):395-8.
Cafarchia, C., Figueredo, L. A., Iatta, R., Montagna, M. T., & Otranto, D. (2012). In vitro antifungal susceptibility of Malassezia pachydermatis from dogs with and without skin lesions. Veterinary Microbiology, 155(2-4), 395-8. https://doi.org/10.1016/j.vetmic.2011.09.008
Cafarchia C, et al. In Vitro Antifungal Susceptibility of Malassezia Pachydermatis From Dogs With and Without Skin Lesions. Vet Microbiol. 2012 Mar 23;155(2-4):395-8. PubMed PMID: 21962411.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro antifungal susceptibility of Malassezia pachydermatis from dogs with and without skin lesions. AU - Cafarchia,Claudia, AU - Figueredo,Luciana A, AU - Iatta,Roberta, AU - Montagna,Maria Teresa, AU - Otranto,Domenico, Y1 - 2011/09/12/ PY - 2011/07/04/received PY - 2011/09/01/revised PY - 2011/09/05/accepted PY - 2011/10/4/entrez PY - 2011/10/4/pubmed PY - 2013/3/28/medline SP - 395 EP - 8 JF - Veterinary microbiology JO - Vet. Microbiol. VL - 155 IS - 2-4 N2 - Canine Malassezia dermatitis is frequently treated with systemic ketoconazole (KTZ) and itraconazole (ITZ). However, no information is available on the antifungal susceptibility to azoles and allilamine of Malassezia pachydermatis isolates from dogs with or without skin lesions. The present study was designed to evaluate the in vitro antifungal susceptibility of M. pachydermatis strains from dogs with or without skin lesions to KTZ, ITZ, miconazole (MICO), fluconazole (FLZ), posaconazole (POS), voriconazole (VOR) and terbinafine (TER) using the Clinical and Laboratory Standards Institute reference Broth Microdilution Method (CLSI M27-A2). The association between the susceptibility to antifungal compounds and the origin of M. pachydermatis, from skin with or without lesions has been also assessed. A total of 62 M. pachydermatis strains from healthy dogs (i.e., Group A=30) or with skin lesions (i.e., Group B=32) were tested. ITZ, KTZ and POS showed the highest activity against M. pachydermatis strains, whereas MICO TER and FLZ the lowest. A higher number of Malassezia resistant strains were registered among isolates from Group B than those from Group A. This study indicates that M. pachydermatis strains were susceptible to ITZ, KTZ, and POS. However, dogs with lesions may harbour strains with low susceptibility to antifungal agents and displaying cross-resistance phenomena to azole. The antifungal therapy in Malassezia infections requires careful appraisal of choice of drugs especially in cases of unresponsiveness to antifungal treatment or recurrent infections. SN - 1873-2542 UR - https://www.unboundmedicine.com/medline/citation/21962411/In_vitro_antifungal_susceptibility_of_Malassezia_pachydermatis_from_dogs_with_and_without_skin_lesions_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-1135(11)00502-5 DB - PRIME DP - Unbound Medicine ER -