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Fruit and vegetable consumption and the risk of proximal colon, distal colon, and rectal cancers in a case-control study in Western Australia.
J Am Diet Assoc 2011; 111(10):1479-90JA

Abstract

BACKGROUND

Fruits and vegetables (F/V) have been examined extensively in nutrition research in relation to colorectal cancer (CRC). However, their protective effect is subject to debate, possibly because of different effects on different subsites of the large bowel.

OBJECTIVE

To determine whether any association between F/V consumption and risk of CRC differed by subsite of the bowel (proximal colon, distal colon, and rectum).

DESIGN

The Western Australian Bowel Health Study is a population-based, case-control study conducted between June 2005 and August 2007. Complete food frequency questionnaire data were analysed from 834 CRC cases and 939 controls. Logistic regression analysis was used to estimate the effects of quartiles of F/V intake on risk of CRC at different subsites. Odds ratios (OR) and 95% confidence intervals (CI) were calculated for CRC overall and for the three separate subsites.

RESULTS

Risk of proximal colon cancer and rectal cancer was not associated with intakes of total F/V, total vegetable, or total fruit. Brassica vegetable intake was inversely related with proximal colon cancer (Q4 vs Q1 OR 0.62; 95% CI 0.41 to 0.93). For distal colon cancer, significant negative trends were seen for total F/V, and total vegetable intake. Distal colon cancer risk was significantly decreased for intake of dark yellow vegetables (Q4 vs Q1 OR 0.61; 95% CI 0.41 to 0.92) and apples (Q4 vs Q1 OR 0.51; 95% CI 0.34 to 0.77). An increased risk for CRC was found to be associated with intake of fruit juice (Q4 vs Q1 OR 1.74; 95% CI 1.24 to 2.45).

CONCLUSIONS

Our results suggest that different F/V may confer different risks for cancer of the proximal colon, distal colon, or rectum. Future studies might consider taking into account the location of the tumor when examining the relation between F/V consumption and risk of CRC.

Authors+Show Affiliations

Western Australian Institute for Medical Research, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21963014

Citation

Annema, Neeltje, et al. "Fruit and Vegetable Consumption and the Risk of Proximal Colon, Distal Colon, and Rectal Cancers in a Case-control Study in Western Australia." Journal of the American Dietetic Association, vol. 111, no. 10, 2011, pp. 1479-90.
Annema N, Heyworth JS, McNaughton SA, et al. Fruit and vegetable consumption and the risk of proximal colon, distal colon, and rectal cancers in a case-control study in Western Australia. J Am Diet Assoc. 2011;111(10):1479-90.
Annema, N., Heyworth, J. S., McNaughton, S. A., Iacopetta, B., & Fritschi, L. (2011). Fruit and vegetable consumption and the risk of proximal colon, distal colon, and rectal cancers in a case-control study in Western Australia. Journal of the American Dietetic Association, 111(10), pp. 1479-90. doi:10.1016/j.jada.2011.07.008.
Annema N, et al. Fruit and Vegetable Consumption and the Risk of Proximal Colon, Distal Colon, and Rectal Cancers in a Case-control Study in Western Australia. J Am Diet Assoc. 2011;111(10):1479-90. PubMed PMID: 21963014.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fruit and vegetable consumption and the risk of proximal colon, distal colon, and rectal cancers in a case-control study in Western Australia. AU - Annema,Neeltje, AU - Heyworth,Jane S, AU - McNaughton,Sarah A, AU - Iacopetta,Barry, AU - Fritschi,Lin, PY - 2010/10/20/received PY - 2011/05/09/accepted PY - 2011/10/4/entrez PY - 2011/10/4/pubmed PY - 2011/11/10/medline SP - 1479 EP - 90 JF - Journal of the American Dietetic Association JO - J Am Diet Assoc VL - 111 IS - 10 N2 - BACKGROUND: Fruits and vegetables (F/V) have been examined extensively in nutrition research in relation to colorectal cancer (CRC). However, their protective effect is subject to debate, possibly because of different effects on different subsites of the large bowel. OBJECTIVE: To determine whether any association between F/V consumption and risk of CRC differed by subsite of the bowel (proximal colon, distal colon, and rectum). DESIGN: The Western Australian Bowel Health Study is a population-based, case-control study conducted between June 2005 and August 2007. Complete food frequency questionnaire data were analysed from 834 CRC cases and 939 controls. Logistic regression analysis was used to estimate the effects of quartiles of F/V intake on risk of CRC at different subsites. Odds ratios (OR) and 95% confidence intervals (CI) were calculated for CRC overall and for the three separate subsites. RESULTS: Risk of proximal colon cancer and rectal cancer was not associated with intakes of total F/V, total vegetable, or total fruit. Brassica vegetable intake was inversely related with proximal colon cancer (Q4 vs Q1 OR 0.62; 95% CI 0.41 to 0.93). For distal colon cancer, significant negative trends were seen for total F/V, and total vegetable intake. Distal colon cancer risk was significantly decreased for intake of dark yellow vegetables (Q4 vs Q1 OR 0.61; 95% CI 0.41 to 0.92) and apples (Q4 vs Q1 OR 0.51; 95% CI 0.34 to 0.77). An increased risk for CRC was found to be associated with intake of fruit juice (Q4 vs Q1 OR 1.74; 95% CI 1.24 to 2.45). CONCLUSIONS: Our results suggest that different F/V may confer different risks for cancer of the proximal colon, distal colon, or rectum. Future studies might consider taking into account the location of the tumor when examining the relation between F/V consumption and risk of CRC. SN - 1878-3570 UR - https://www.unboundmedicine.com/medline/citation/21963014/Fruit_and_vegetable_consumption_and_the_risk_of_proximal_colon_distal_colon_and_rectal_cancers_in_a_case_control_study_in_Western_Australia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-8223(11)01215-6 DB - PRIME DP - Unbound Medicine ER -