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Antihyperglycemic activity and antidiabetic effect of methyl caffeate isolated from Solanum torvum Swartz. fruit in streptozotocin induced diabetic rats.
Eur J Pharmacol. 2011 Nov 30; 670(2-3):623-31.EJ

Abstract

Natural remedies from medicinal plants are considered to be effective and safe alternatives to treat diabetes mellitus. Solanum torvum Swartz. fruit is widely used in the traditional system of medicine to treat diabetes. In the present study methyl caffeate, isolated from S. torvum fruit, was screened for its efficacy in controlling diabetes in animal models. Antihyperglycemic effect of methyl caffeate was studied in normal glucose-fed rats. The effects of oral administration of methyl caffeate (10, 20 and 40 mg/kg) for 28 days on body weight, fasting blood glucose, plasma insulin, hemoglobin, glycated hemoglobin, total protein, hepatic glycogen and carbohydrate metabolism enzymes in streptozotocin induced diabetic rats were investigated. Histological observations in the pancreas and GLUT4 expression in skeletal muscles were also studied. Methyl caffeate at 40 mg/kg significantly prevented the increase in blood glucose level after glucose administration at 60 min in comparison to the hyperglycemic control group. In streptozotocin induced diabetic rats, methyl caffeate produced significant reduction in blood glucose and increased body weight. The levels and/or activities of other biochemical parameters were near normal due to treatment with methyl caffeate. Methyl caffeate treated diabetic rats showed upregulation of GLUT4 and regeneration of β-cells in the pancreas. These results substantiated that methyl caffeate possessed hypoglycemic effect, and it could be developed into a potent oral antidiabetic drug.

Authors+Show Affiliations

Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Chennai 600 034, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21963451

Citation

Gandhi, Gopalsamy Rajiv, et al. "Antihyperglycemic Activity and Antidiabetic Effect of Methyl Caffeate Isolated From Solanum Torvum Swartz. Fruit in Streptozotocin Induced Diabetic Rats." European Journal of Pharmacology, vol. 670, no. 2-3, 2011, pp. 623-31.
Gandhi GR, Ignacimuthu S, Paulraj MG, et al. Antihyperglycemic activity and antidiabetic effect of methyl caffeate isolated from Solanum torvum Swartz. fruit in streptozotocin induced diabetic rats. Eur J Pharmacol. 2011;670(2-3):623-31.
Gandhi, G. R., Ignacimuthu, S., Paulraj, M. G., & Sasikumar, P. (2011). Antihyperglycemic activity and antidiabetic effect of methyl caffeate isolated from Solanum torvum Swartz. fruit in streptozotocin induced diabetic rats. European Journal of Pharmacology, 670(2-3), 623-31. https://doi.org/10.1016/j.ejphar.2011.09.159
Gandhi GR, et al. Antihyperglycemic Activity and Antidiabetic Effect of Methyl Caffeate Isolated From Solanum Torvum Swartz. Fruit in Streptozotocin Induced Diabetic Rats. Eur J Pharmacol. 2011 Nov 30;670(2-3):623-31. PubMed PMID: 21963451.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antihyperglycemic activity and antidiabetic effect of methyl caffeate isolated from Solanum torvum Swartz. fruit in streptozotocin induced diabetic rats. AU - Gandhi,Gopalsamy Rajiv, AU - Ignacimuthu,Savarimuthu, AU - Paulraj,Michael Gabriel, AU - Sasikumar,Ponnusamy, Y1 - 2011/09/24/ PY - 2011/04/28/received PY - 2011/09/05/revised PY - 2011/09/11/accepted PY - 2011/10/4/entrez PY - 2011/10/4/pubmed PY - 2012/3/1/medline SP - 623 EP - 31 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 670 IS - 2-3 N2 - Natural remedies from medicinal plants are considered to be effective and safe alternatives to treat diabetes mellitus. Solanum torvum Swartz. fruit is widely used in the traditional system of medicine to treat diabetes. In the present study methyl caffeate, isolated from S. torvum fruit, was screened for its efficacy in controlling diabetes in animal models. Antihyperglycemic effect of methyl caffeate was studied in normal glucose-fed rats. The effects of oral administration of methyl caffeate (10, 20 and 40 mg/kg) for 28 days on body weight, fasting blood glucose, plasma insulin, hemoglobin, glycated hemoglobin, total protein, hepatic glycogen and carbohydrate metabolism enzymes in streptozotocin induced diabetic rats were investigated. Histological observations in the pancreas and GLUT4 expression in skeletal muscles were also studied. Methyl caffeate at 40 mg/kg significantly prevented the increase in blood glucose level after glucose administration at 60 min in comparison to the hyperglycemic control group. In streptozotocin induced diabetic rats, methyl caffeate produced significant reduction in blood glucose and increased body weight. The levels and/or activities of other biochemical parameters were near normal due to treatment with methyl caffeate. Methyl caffeate treated diabetic rats showed upregulation of GLUT4 and regeneration of β-cells in the pancreas. These results substantiated that methyl caffeate possessed hypoglycemic effect, and it could be developed into a potent oral antidiabetic drug. SN - 1879-0712 UR - https://www.unboundmedicine.com/medline/citation/21963451/Antihyperglycemic_activity_and_antidiabetic_effect_of_methyl_caffeate_isolated_from_Solanum_torvum_Swartz__fruit_in_streptozotocin_induced_diabetic_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(11)01142-3 DB - PRIME DP - Unbound Medicine ER -