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Regulation of angiotensin-(1-7) and angiotensin II type 1 receptor by telmisartan and losartan in adriamycin-induced rat heart failure.
Acta Pharmacol Sin. 2011 Nov; 32(11):1345-50.AP

Abstract

AIM

To investigate the possible effects of telmisartan and losartan on cardiac function in adriamycin (ADR)-induced heart failure in rats, and to explore the changes in plasma level of angiotensin-(1-7)[Ang-(1-7)] and myocardial expression of angiotensin II type 1/2 receptors (AT(1)R / AT(2)R) and Mas receptor caused by the two drugs.

METHODS

Male Sprague-Dawley rats were randomly divided into 4 groups: the control group, ADR-treated heart failure group (ADR-HF), telmisartan plus ADR-treated group (Tel+ADR) and losartan plus ADR-treated group (Los+ADR). ADR was administrated (2.5 mg/kg, ip, 6 times in 2 weeks). The rats in the Tel+ADR and Los+ADR groups were treated orally with telmisartan (10 mg/kg daily po) and losartan (30 mg/kg daily), respectively, for 6 weeks. The plasma level of Ang-(1-7) was determined using ELISA. The mRNA and protein expression of myocardial Mas receptor, AT(1)R and AT(2)R were measured using RT-PCR and Western blotting, respectively.

RESULTS

ADR significantly reduced the plasma level of Ang-(1-7) and the expression of myocardial Mas receptor and myocardial AT(2)R, while significantly increased the expression of myocardial AT(1)R. Treatment with telmisartan and losartan effectively increased the plasma level of Ang-(1-7) and suppressed myocardial AT(1)R expression, but did not influence the expression of Mas receptor and AT(2)R.

CONCLUSION

The protective effects of telmisartan and losartan in ADR-induced heart failure may be partially due to regulation of circulating Ang-(1-7) and myocardial AT(1)R expression.

Authors+Show Affiliations

Department of Cardiology, First Affiliated Hospital, Nanjing Medical University, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21963897

Citation

Zong, Wen-na, et al. "Regulation of Angiotensin-(1-7) and Angiotensin II Type 1 Receptor By Telmisartan and Losartan in Adriamycin-induced Rat Heart Failure." Acta Pharmacologica Sinica, vol. 32, no. 11, 2011, pp. 1345-50.
Zong WN, Yang XH, Chen XM, et al. Regulation of angiotensin-(1-7) and angiotensin II type 1 receptor by telmisartan and losartan in adriamycin-induced rat heart failure. Acta Pharmacol Sin. 2011;32(11):1345-50.
Zong, W. N., Yang, X. H., Chen, X. M., Huang, H. J., Zheng, H. J., Qin, X. Y., Yong, Y. H., Cao, K., Huang, J., & Lu, X. Z. (2011). Regulation of angiotensin-(1-7) and angiotensin II type 1 receptor by telmisartan and losartan in adriamycin-induced rat heart failure. Acta Pharmacologica Sinica, 32(11), 1345-50. https://doi.org/10.1038/aps.2011.96
Zong WN, et al. Regulation of Angiotensin-(1-7) and Angiotensin II Type 1 Receptor By Telmisartan and Losartan in Adriamycin-induced Rat Heart Failure. Acta Pharmacol Sin. 2011;32(11):1345-50. PubMed PMID: 21963897.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regulation of angiotensin-(1-7) and angiotensin II type 1 receptor by telmisartan and losartan in adriamycin-induced rat heart failure. AU - Zong,Wen-na, AU - Yang,Xiao-hui, AU - Chen,Xiu-mei, AU - Huang,Hong-juan, AU - Zheng,Hong-jian, AU - Qin,Xiao-yi, AU - Yong,Yong-hong, AU - Cao,Kejiang, AU - Huang,Jun, AU - Lu,Xin-zheng, Y1 - 2011/10/03/ PY - 2011/10/4/entrez PY - 2011/10/4/pubmed PY - 2012/3/3/medline SP - 1345 EP - 50 JF - Acta pharmacologica Sinica JO - Acta Pharmacol Sin VL - 32 IS - 11 N2 - AIM: To investigate the possible effects of telmisartan and losartan on cardiac function in adriamycin (ADR)-induced heart failure in rats, and to explore the changes in plasma level of angiotensin-(1-7)[Ang-(1-7)] and myocardial expression of angiotensin II type 1/2 receptors (AT(1)R / AT(2)R) and Mas receptor caused by the two drugs. METHODS: Male Sprague-Dawley rats were randomly divided into 4 groups: the control group, ADR-treated heart failure group (ADR-HF), telmisartan plus ADR-treated group (Tel+ADR) and losartan plus ADR-treated group (Los+ADR). ADR was administrated (2.5 mg/kg, ip, 6 times in 2 weeks). The rats in the Tel+ADR and Los+ADR groups were treated orally with telmisartan (10 mg/kg daily po) and losartan (30 mg/kg daily), respectively, for 6 weeks. The plasma level of Ang-(1-7) was determined using ELISA. The mRNA and protein expression of myocardial Mas receptor, AT(1)R and AT(2)R were measured using RT-PCR and Western blotting, respectively. RESULTS: ADR significantly reduced the plasma level of Ang-(1-7) and the expression of myocardial Mas receptor and myocardial AT(2)R, while significantly increased the expression of myocardial AT(1)R. Treatment with telmisartan and losartan effectively increased the plasma level of Ang-(1-7) and suppressed myocardial AT(1)R expression, but did not influence the expression of Mas receptor and AT(2)R. CONCLUSION: The protective effects of telmisartan and losartan in ADR-induced heart failure may be partially due to regulation of circulating Ang-(1-7) and myocardial AT(1)R expression. SN - 1745-7254 UR - https://www.unboundmedicine.com/medline/citation/21963897/Regulation_of_angiotensin__1_7__and_angiotensin_II_type_1_receptor_by_telmisartan_and_losartan_in_adriamycin_induced_rat_heart_failure_ L2 - https://doi.org/10.1038/aps.2011.96 DB - PRIME DP - Unbound Medicine ER -