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Addressing potent single molecule AFM study in prediction of swelling and dissolution rate in polymer matrix tablets.
Eur J Pharm Biopharm. 2012 Jan; 80(1):217-25.EJ

Abstract

Our goal was to understand and thus be able to predict the swelling behavior of xanthan matrix tablets in media of various pH and ionic strengths using data obtained from single xanthan molecules and films with atomic force microscopy. Imaging was performed in 1-butanol using contact mode AFM in order to characterize single xanthan chains prepared from various solutions. Image analysis was used to calculate the molecular contour, persistence length, and radius of gyration. Nanoindentation measurements of xanthan films were carried out to evaluate their mechanical properties. Increasing the ionic strength of solutions induced reductions in chain parameters such as molecular contour, persistence length, and radius of gyration. Nanomechanical measurements demonstrated that Young's moduli of xanthan films prepared from solutions with higher ionic strengths are twice as large as those prepared at lower ionic strengths. This may help explain xanthan matrix tablets' reduced degree of swelling and faster dissolution rate in the presence of salts or ions. We successfully come to conclusion that microscopic polymer properties such as radius of gyration and persistence length are responsible for the macroscopic polymer behavior. For instance, longer persistence lengths and radius of gyration of xanthan's chains result in a higher degree of swelling, corresponding to softer polymer films, increased gel layers in matrix, and a slower release rate of the incorporated drug from the tablets.

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Authors+Show Affiliations

Govedarica B
Department of Pharmaceutical Technology, University of Ljubljana, Ljubljana, Slovenia. biljana.govedarica@ffa.uni-lj.si
Sovány T
No affiliation info available
Pintye-Hódi K
No affiliation info available
Skarabot M
No affiliation info available
Baumgartner S
No affiliation info available
Muševič I
No affiliation info available
Srčič S
No affiliation info available

MeSH

1-ButanolDelayed-Action PreparationsHydrogen-Ion ConcentrationMechanical PhenomenaMicroscopy, Atomic ForceNanotechnologyOsmolar ConcentrationPolymersPolysaccharides, BacterialSolubilitySolutionsStatistics as TopicTablets

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21964202

Citation

Govedarica, Biljana, et al. "Addressing Potent Single Molecule AFM Study in Prediction of Swelling and Dissolution Rate in Polymer Matrix Tablets." European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, vol. 80, no. 1, 2012, pp. 217-25.
Govedarica B, Sovány T, Pintye-Hódi K, et al. Addressing potent single molecule AFM study in prediction of swelling and dissolution rate in polymer matrix tablets. Eur J Pharm Biopharm. 2012;80(1):217-25.
Govedarica, B., Sovány, T., Pintye-Hódi, K., Skarabot, M., Baumgartner, S., Muševič, I., & Srčič, S. (2012). Addressing potent single molecule AFM study in prediction of swelling and dissolution rate in polymer matrix tablets. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, 80(1), 217-25. https://doi.org/10.1016/j.ejpb.2011.09.008
Govedarica B, et al. Addressing Potent Single Molecule AFM Study in Prediction of Swelling and Dissolution Rate in Polymer Matrix Tablets. Eur J Pharm Biopharm. 2012;80(1):217-25. PubMed PMID: 21964202.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Addressing potent single molecule AFM study in prediction of swelling and dissolution rate in polymer matrix tablets. AU - Govedarica,Biljana, AU - Sovány,Tamás, AU - Pintye-Hódi,Klara, AU - Skarabot,Miha, AU - Baumgartner,Saša, AU - Muševič,Igor, AU - Srčič,Stane, Y1 - 2011/09/21/ PY - 2011/07/03/received PY - 2011/09/12/accepted PY - 2011/10/4/entrez PY - 2011/10/4/pubmed PY - 2012/7/3/medline SP - 217 EP - 25 JF - European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V JO - Eur J Pharm Biopharm VL - 80 IS - 1 N2 - Our goal was to understand and thus be able to predict the swelling behavior of xanthan matrix tablets in media of various pH and ionic strengths using data obtained from single xanthan molecules and films with atomic force microscopy. Imaging was performed in 1-butanol using contact mode AFM in order to characterize single xanthan chains prepared from various solutions. Image analysis was used to calculate the molecular contour, persistence length, and radius of gyration. Nanoindentation measurements of xanthan films were carried out to evaluate their mechanical properties. Increasing the ionic strength of solutions induced reductions in chain parameters such as molecular contour, persistence length, and radius of gyration. Nanomechanical measurements demonstrated that Young's moduli of xanthan films prepared from solutions with higher ionic strengths are twice as large as those prepared at lower ionic strengths. This may help explain xanthan matrix tablets' reduced degree of swelling and faster dissolution rate in the presence of salts or ions. We successfully come to conclusion that microscopic polymer properties such as radius of gyration and persistence length are responsible for the macroscopic polymer behavior. For instance, longer persistence lengths and radius of gyration of xanthan's chains result in a higher degree of swelling, corresponding to softer polymer films, increased gel layers in matrix, and a slower release rate of the incorporated drug from the tablets. SN - 1873-3441 UR - https://www.unboundmedicine.com/medline/citation/21964202/Addressing_potent_single_molecule_AFM_study_in_prediction_of_swelling_and_dissolution_rate_in_polymer_matrix_tablets_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-6411(11)00269-4 DB - PRIME DP - Unbound Medicine ER -