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Vitamin D deficiency and rickets in children and adolescents with ichthyosiform erythroderma in type IV and V skin.
Br J Dermatol 2012; 166(3):608-15BJ

Abstract

BACKGROUND

Ichthyosiform erythroderma due to keratinizing disorders may suppress cutaneous vitamin D synthesis, leading to vitamin D deficiency and rickets.

OBJECTIVES

To determine the prevalence of vitamin D deficiency and rickets in children and adolescents with congenital ichthyosis and other keratinizing disorders with erythroderma and scaling.

PATIENTS AND METHODS

In this cross-sectional study, 45 children and adolescents with ichthyosiform erythroderma due to keratinizing disorders, and 66 controls (group 1: age and sex matched, with skin diseases other than keratinizing disorders; group 2: age and sex matched, healthy volunteers) were included. Evidence of rickets was determined clinically (physical examination and radiographs) and biochemically {serum calcium, phosphorus, alkaline phosphatase, 25-hydroxy vitamin D [25(OH)D] and parathyroid hormone (PTH)}.

RESULTS

All patients in the disease group had clinical, radiological or biochemical evidence of rickets [25(OH)D<20ngmL(-1) ], and analysis was done for all subjects with the available biochemical reports. The mean serum 25(OH)D levels of the disease group was 8·38±5·23ngmL(-1) and was significantly lower than in control group 1 (11·1±5·8ngmL(-1) ) (P<0·01) and control group 2 (13·5±6·9ngmL(-1) ) (P<0·001). The prevalence of vitamin D deficiency [25(OH)D<20ngmL(-1) ] was significantly higher in the disease group (n=38 of 39, 97·4%) than in control group 2 (n=12, 70·6%) (P<0·01), and total controls (n=56, 84·8%) (P=0·04). The frequency of hyperparathyroidism (PTH>65pgmL(-1) ) was also significantly higher in the disease group than in controls (P<0·01).

CONCLUSIONS

Children and adolescents with various forms of ichthyosiform erythroderma, especially those with pigmented skin (types IV-VI), are at increased risk of developing vitamin D deficiency and clinical rickets.

Authors+Show Affiliations

Departments of Dermatology, Endocrinology and Metabolism, Paediatrics, Biostatistics and Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21967076

Citation

Chouhan, K, et al. "Vitamin D Deficiency and Rickets in Children and Adolescents With Ichthyosiform Erythroderma in Type IV and V Skin." The British Journal of Dermatology, vol. 166, no. 3, 2012, pp. 608-15.
Chouhan K, Sethuraman G, Gupta N, et al. Vitamin D deficiency and rickets in children and adolescents with ichthyosiform erythroderma in type IV and V skin. Br J Dermatol. 2012;166(3):608-15.
Chouhan, K., Sethuraman, G., Gupta, N., Sharma, V. K., Kabra, M., Khaitan, B. K., ... Paller, A. S. (2012). Vitamin D deficiency and rickets in children and adolescents with ichthyosiform erythroderma in type IV and V skin. The British Journal of Dermatology, 166(3), pp. 608-15. doi:10.1111/j.1365-2133.2011.10672.x.
Chouhan K, et al. Vitamin D Deficiency and Rickets in Children and Adolescents With Ichthyosiform Erythroderma in Type IV and V Skin. Br J Dermatol. 2012;166(3):608-15. PubMed PMID: 21967076.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D deficiency and rickets in children and adolescents with ichthyosiform erythroderma in type IV and V skin. AU - Chouhan,K, AU - Sethuraman,G, AU - Gupta,N, AU - Sharma,V K, AU - Kabra,M, AU - Khaitan,B K, AU - Sreenivas,V, AU - Ramam,M, AU - Kusumakar,S, AU - Thulkar,S, AU - Paller,A S, PY - 2011/10/5/entrez PY - 2011/10/5/pubmed PY - 2012/4/28/medline SP - 608 EP - 15 JF - The British journal of dermatology JO - Br. J. Dermatol. VL - 166 IS - 3 N2 - BACKGROUND: Ichthyosiform erythroderma due to keratinizing disorders may suppress cutaneous vitamin D synthesis, leading to vitamin D deficiency and rickets. OBJECTIVES: To determine the prevalence of vitamin D deficiency and rickets in children and adolescents with congenital ichthyosis and other keratinizing disorders with erythroderma and scaling. PATIENTS AND METHODS: In this cross-sectional study, 45 children and adolescents with ichthyosiform erythroderma due to keratinizing disorders, and 66 controls (group 1: age and sex matched, with skin diseases other than keratinizing disorders; group 2: age and sex matched, healthy volunteers) were included. Evidence of rickets was determined clinically (physical examination and radiographs) and biochemically {serum calcium, phosphorus, alkaline phosphatase, 25-hydroxy vitamin D [25(OH)D] and parathyroid hormone (PTH)}. RESULTS: All patients in the disease group had clinical, radiological or biochemical evidence of rickets [25(OH)D<20ngmL(-1) ], and analysis was done for all subjects with the available biochemical reports. The mean serum 25(OH)D levels of the disease group was 8·38±5·23ngmL(-1) and was significantly lower than in control group 1 (11·1±5·8ngmL(-1) ) (P<0·01) and control group 2 (13·5±6·9ngmL(-1) ) (P<0·001). The prevalence of vitamin D deficiency [25(OH)D<20ngmL(-1) ] was significantly higher in the disease group (n=38 of 39, 97·4%) than in control group 2 (n=12, 70·6%) (P<0·01), and total controls (n=56, 84·8%) (P=0·04). The frequency of hyperparathyroidism (PTH>65pgmL(-1) ) was also significantly higher in the disease group than in controls (P<0·01). CONCLUSIONS: Children and adolescents with various forms of ichthyosiform erythroderma, especially those with pigmented skin (types IV-VI), are at increased risk of developing vitamin D deficiency and clinical rickets. SN - 1365-2133 UR - https://www.unboundmedicine.com/medline/citation/21967076/Vitamin_D_deficiency_and_rickets_in_children_and_adolescents_with_ichthyosiform_erythroderma_in_type_IV_and_V_skin_ L2 - https://doi.org/10.1111/j.1365-2133.2011.10672.x DB - PRIME DP - Unbound Medicine ER -