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Antiallodynic effect and side effects of Phα1β, a neurotoxin from the spider Phoneutria nigriventer: comparison with ω-conotoxin MVIIA and morphine.
Toxicon. 2011 Dec 01; 58(8):626-33.T

Abstract

Phα1β is a potent toxin obtained from the spider Phoneutria nigriventer that blocks neuronal voltage-sensitive Ca(2+) channels. This study compared the antiallodynic effects of Phα1β, ω-conotoxin MVIIA and morphine in mice and their side effects in rats. Mechanical allodynia was measured in mice receiving single intrathecal administration of Phα1β, ω-conotoxin MVIIA or morphine before or after the incisional plantar procedure. The effect of the treatments on cardiovascular profile and global neurological were evaluated in rats. The expression of pro or anti-inflammatory cytokines of human polymorph mononuclear cells was also evaluated. Preemptive use of ω-conotoxin MVIIA (1.0 or 10 pmol/site) or morphine (1000 pmol/site) induced shorter antiallodynic effect than Phα1β (100 pmol/site) in mice. Post-incision administration of Phα1β (200 pmol/site) induced longer mechanical antiallodynic effect than ω-conotoxin MVIIA (1.0 or 10 pmol/site) or morphine (1000 pmol/site). Intrathecal injection of Phα1β (200 pmol/site) and morphine (433 pmol/site) did not change while ω-conotoxin MVIIA (100 pmol/site) increased the heart rate in rats 3 h after its administration. Phα1β (200 pmol/site), ω-conotoxin MVIIA (100 pmol/site) and morphine (433 pmol/site) did not change mean arterial pressure 0.5 and 3 h after their administration. The treatments did not alter neurological performance assessed by global neurological evaluation and open-field test. The tested drugs did not induced expression of pro or anti-inflammatory cytokines in CD4 monocytes. In conclusion, preemptive administration Phα1β in mice induced longer antiallodynic effect than ω-conotoxin MVIIA and morphine. Phα1β also induced a longer mechanical antiallodynic effect than ω-conotoxin MVIIA and morphine when used after the surgical incision. The present results suggest that Phα1β has a potential application in the management of postoperative pain with low side effects.

Authors+Show Affiliations

Laboratório de Neurociência, UFMG, Belo Horizonte, Minas Gerais, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21967810

Citation

de Souza, A H., et al. "Antiallodynic Effect and Side Effects of Phα1β, a Neurotoxin From the Spider Phoneutria Nigriventer: Comparison With Ω-conotoxin MVIIA and Morphine." Toxicon : Official Journal of the International Society On Toxinology, vol. 58, no. 8, 2011, pp. 626-33.
de Souza AH, Lima MC, Drewes CC, et al. Antiallodynic effect and side effects of Phα1β, a neurotoxin from the spider Phoneutria nigriventer: comparison with ω-conotoxin MVIIA and morphine. Toxicon. 2011;58(8):626-33.
de Souza, A. H., Lima, M. C., Drewes, C. C., da Silva, J. F., Torres, K. C., Pereira, E. M., de Castro Junior, C. J., Vieira, L. B., Cordeiro, M. N., Richardson, M., Gomez, R. S., Romano-Silva, M. A., Ferreira, J., & Gomez, M. V. (2011). Antiallodynic effect and side effects of Phα1β, a neurotoxin from the spider Phoneutria nigriventer: comparison with ω-conotoxin MVIIA and morphine. Toxicon : Official Journal of the International Society On Toxinology, 58(8), 626-33. https://doi.org/10.1016/j.toxicon.2011.09.008
de Souza AH, et al. Antiallodynic Effect and Side Effects of Phα1β, a Neurotoxin From the Spider Phoneutria Nigriventer: Comparison With Ω-conotoxin MVIIA and Morphine. Toxicon. 2011 Dec 1;58(8):626-33. PubMed PMID: 21967810.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antiallodynic effect and side effects of Phα1β, a neurotoxin from the spider Phoneutria nigriventer: comparison with ω-conotoxin MVIIA and morphine. AU - de Souza,A H, AU - Lima,M C, AU - Drewes,C C, AU - da Silva,J F, AU - Torres,K C L, AU - Pereira,E M R, AU - de Castro Junior,C J, AU - Vieira,L B, AU - Cordeiro,M N, AU - Richardson,M, AU - Gomez,R S, AU - Romano-Silva,M A, AU - Ferreira,J, AU - Gomez,M V, Y1 - 2011/09/24/ PY - 2011/06/30/received PY - 2011/09/13/revised PY - 2011/09/20/accepted PY - 2011/10/5/entrez PY - 2011/10/5/pubmed PY - 2012/3/16/medline SP - 626 EP - 33 JF - Toxicon : official journal of the International Society on Toxinology JO - Toxicon VL - 58 IS - 8 N2 - Phα1β is a potent toxin obtained from the spider Phoneutria nigriventer that blocks neuronal voltage-sensitive Ca(2+) channels. This study compared the antiallodynic effects of Phα1β, ω-conotoxin MVIIA and morphine in mice and their side effects in rats. Mechanical allodynia was measured in mice receiving single intrathecal administration of Phα1β, ω-conotoxin MVIIA or morphine before or after the incisional plantar procedure. The effect of the treatments on cardiovascular profile and global neurological were evaluated in rats. The expression of pro or anti-inflammatory cytokines of human polymorph mononuclear cells was also evaluated. Preemptive use of ω-conotoxin MVIIA (1.0 or 10 pmol/site) or morphine (1000 pmol/site) induced shorter antiallodynic effect than Phα1β (100 pmol/site) in mice. Post-incision administration of Phα1β (200 pmol/site) induced longer mechanical antiallodynic effect than ω-conotoxin MVIIA (1.0 or 10 pmol/site) or morphine (1000 pmol/site). Intrathecal injection of Phα1β (200 pmol/site) and morphine (433 pmol/site) did not change while ω-conotoxin MVIIA (100 pmol/site) increased the heart rate in rats 3 h after its administration. Phα1β (200 pmol/site), ω-conotoxin MVIIA (100 pmol/site) and morphine (433 pmol/site) did not change mean arterial pressure 0.5 and 3 h after their administration. The treatments did not alter neurological performance assessed by global neurological evaluation and open-field test. The tested drugs did not induced expression of pro or anti-inflammatory cytokines in CD4 monocytes. In conclusion, preemptive administration Phα1β in mice induced longer antiallodynic effect than ω-conotoxin MVIIA and morphine. Phα1β also induced a longer mechanical antiallodynic effect than ω-conotoxin MVIIA and morphine when used after the surgical incision. The present results suggest that Phα1β has a potential application in the management of postoperative pain with low side effects. SN - 1879-3150 UR - https://www.unboundmedicine.com/medline/citation/21967810/Antiallodynic_effect_and_side_effects_of_Phα1β_a_neurotoxin_from_the_spider_Phoneutria_nigriventer:_comparison_with_ω_conotoxin_MVIIA_and_morphine_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0041-0101(11)00284-4 DB - PRIME DP - Unbound Medicine ER -