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Berberine prevents 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis: a biochemical approach.
Eur J Cancer Prev. 2012 Mar; 21(2):182-92.EJ

Abstract

Chemoprevention, a novel and useful approach in experimental oncology, deals with the prevention, suppression, or inhibition of carcinogenesis using natural or synthetic entities. This study evaluated the chemopreventive potential of berberine on 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch carcinogenesis. Oral squamous cell carcinoma was developed in the buccal pouch of golden Syrian hamsters by painting with 0.5% DMBA in liquid paraffin three times a week for 14 weeks. Tumor incidence, tumor volume, tumor burden, phase I and phase II carcinogen detoxification agents, lipid peroxidation, antioxidant status, and histopathological changes were assessed in hamsters treated with DMBA alone and in DMBA+berberine-treated animals. Hundred percent tumor incidences with an imbalance in carcinogen-metabolizing enzymes and cellular redox status were observed in hamsters treated with DMBA alone. Oral administration of berberine at a dose of 75 mg/kg body weight (bw) to DMBA-treated hamsters completely prevented tumor incidence and restored the status of the above-mentioned biochemical markers. Berberine, a traditional drug from Southeast Asia, shows promising chemopreventive efficacy in hamster buccal pouch carcinogenesis.

Authors+Show Affiliations

Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Tamil Nadu, India. rasmanshisak@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21968688

Citation

Manoharan, Shanmugam, et al. "Berberine Prevents 7,12-dimethylbenz[a]anthracene-induced Hamster Buccal Pouch Carcinogenesis: a Biochemical Approach." European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), vol. 21, no. 2, 2012, pp. 182-92.
Manoharan S, Sindhu G, Vinothkumar V, et al. Berberine prevents 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis: a biochemical approach. Eur J Cancer Prev. 2012;21(2):182-92.
Manoharan, S., Sindhu, G., Vinothkumar, V., & Kowsalya, R. (2012). Berberine prevents 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis: a biochemical approach. European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), 21(2), 182-92. https://doi.org/10.1097/CEJ.0b013e32834c9c3c
Manoharan S, et al. Berberine Prevents 7,12-dimethylbenz[a]anthracene-induced Hamster Buccal Pouch Carcinogenesis: a Biochemical Approach. Eur J Cancer Prev. 2012;21(2):182-92. PubMed PMID: 21968688.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Berberine prevents 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis: a biochemical approach. AU - Manoharan,Shanmugam, AU - Sindhu,Ganapathy, AU - Vinothkumar,Veerasamy, AU - Kowsalya,Raju, PY - 2011/10/5/entrez PY - 2011/10/5/pubmed PY - 2012/5/9/medline SP - 182 EP - 92 JF - European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) JO - Eur J Cancer Prev VL - 21 IS - 2 N2 - Chemoprevention, a novel and useful approach in experimental oncology, deals with the prevention, suppression, or inhibition of carcinogenesis using natural or synthetic entities. This study evaluated the chemopreventive potential of berberine on 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch carcinogenesis. Oral squamous cell carcinoma was developed in the buccal pouch of golden Syrian hamsters by painting with 0.5% DMBA in liquid paraffin three times a week for 14 weeks. Tumor incidence, tumor volume, tumor burden, phase I and phase II carcinogen detoxification agents, lipid peroxidation, antioxidant status, and histopathological changes were assessed in hamsters treated with DMBA alone and in DMBA+berberine-treated animals. Hundred percent tumor incidences with an imbalance in carcinogen-metabolizing enzymes and cellular redox status were observed in hamsters treated with DMBA alone. Oral administration of berberine at a dose of 75 mg/kg body weight (bw) to DMBA-treated hamsters completely prevented tumor incidence and restored the status of the above-mentioned biochemical markers. Berberine, a traditional drug from Southeast Asia, shows promising chemopreventive efficacy in hamster buccal pouch carcinogenesis. SN - 1473-5709 UR - https://www.unboundmedicine.com/medline/citation/21968688/Berberine_prevents_712_dimethylbenz[a]anthracene_induced_hamster_buccal_pouch_carcinogenesis:_a_biochemical_approach_ L2 - https://doi.org/10.1097/CEJ.0b013e32834c9c3c DB - PRIME DP - Unbound Medicine ER -