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Effect of a dietary supplement containing glucosamine hydrochloride, chondroitin sulfate and quercetin glycosides on symptomatic knee osteoarthritis: a randomized, double-blind, placebo-controlled study.
J Sci Food Agric 2012; 92(4):862-9JS

Abstract

BACKGROUND

Oral glucosamine and chondroitin sulfate, alone and in combination, have been used worldwide for the treatment of osteoarthritis (OA), but their efficacy is controversial. This clinical study was aimed at investigating the potential of a dietary supplement containing glucosamine and chondroitin sulfate in combination with derivatives of quercetin, a naturally occurring flavonoid, (GCQ supplement) for knee OA care.

RESULTS

A randomized, double-blind, placebo-controlled study was conducted in 40 Japanese subjects with symptomatic knee OA. Subjects were randomly assigned to GCQ supplement (1200 mg glucosamine hydrochloride, 60 mg chondroitin sulfate and 45 mg quercetin glycosides per day) or placebo and the treatment and follow-up were continued for 16 weeks. The results of symptomatic efficacy assessment based on Japanese Orthopaedic Association criteria showed that scores for two of the four symptom/function subscales, as well as the aggregate scores, were significantly improved at week 16 or earlier in the GCQ group compared to the placebo group. Moreover, analyses of cartilage metabolism biomarkers showed a trend of improvement in type II collagen synthesis/degradation balance in the GCQ group during follow-up.

CONCLUSION

GCQ supplement was thought to be more effective than placebo in decreasing the intensity of knee OA-associated clinical symptoms.

Authors+Show Affiliations

Institute for Health Care Science, Suntory Wellness Ltd, Mishima-gun, Osaka, Japan. Noriyuki_Kanzaki@suntory.co.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

21969261

Citation

Kanzaki, Noriyuki, et al. "Effect of a Dietary Supplement Containing Glucosamine Hydrochloride, Chondroitin Sulfate and Quercetin Glycosides On Symptomatic Knee Osteoarthritis: a Randomized, Double-blind, Placebo-controlled Study." Journal of the Science of Food and Agriculture, vol. 92, no. 4, 2012, pp. 862-9.
Kanzaki N, Saito K, Maeda A, et al. Effect of a dietary supplement containing glucosamine hydrochloride, chondroitin sulfate and quercetin glycosides on symptomatic knee osteoarthritis: a randomized, double-blind, placebo-controlled study. J Sci Food Agric. 2012;92(4):862-9.
Kanzaki, N., Saito, K., Maeda, A., Kitagawa, Y., Kiso, Y., Watanabe, K., ... Yamaguchi, H. (2012). Effect of a dietary supplement containing glucosamine hydrochloride, chondroitin sulfate and quercetin glycosides on symptomatic knee osteoarthritis: a randomized, double-blind, placebo-controlled study. Journal of the Science of Food and Agriculture, 92(4), pp. 862-9. doi:10.1002/jsfa.4660.
Kanzaki N, et al. Effect of a Dietary Supplement Containing Glucosamine Hydrochloride, Chondroitin Sulfate and Quercetin Glycosides On Symptomatic Knee Osteoarthritis: a Randomized, Double-blind, Placebo-controlled Study. J Sci Food Agric. 2012 Mar 15;92(4):862-9. PubMed PMID: 21969261.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of a dietary supplement containing glucosamine hydrochloride, chondroitin sulfate and quercetin glycosides on symptomatic knee osteoarthritis: a randomized, double-blind, placebo-controlled study. AU - Kanzaki,Noriyuki, AU - Saito,Kayo, AU - Maeda,Akifumi, AU - Kitagawa,Yoshinori, AU - Kiso,Yoshinobu, AU - Watanabe,Keita, AU - Tomonaga,Akihito, AU - Nagaoka,Isao, AU - Yamaguchi,Hideyo, Y1 - 2011/10/03/ PY - 2011/04/27/received PY - 2011/08/09/revised PY - 2011/08/19/accepted PY - 2011/10/5/entrez PY - 2011/10/5/pubmed PY - 2012/6/22/medline SP - 862 EP - 9 JF - Journal of the science of food and agriculture JO - J. Sci. Food Agric. VL - 92 IS - 4 N2 - BACKGROUND: Oral glucosamine and chondroitin sulfate, alone and in combination, have been used worldwide for the treatment of osteoarthritis (OA), but their efficacy is controversial. This clinical study was aimed at investigating the potential of a dietary supplement containing glucosamine and chondroitin sulfate in combination with derivatives of quercetin, a naturally occurring flavonoid, (GCQ supplement) for knee OA care. RESULTS: A randomized, double-blind, placebo-controlled study was conducted in 40 Japanese subjects with symptomatic knee OA. Subjects were randomly assigned to GCQ supplement (1200 mg glucosamine hydrochloride, 60 mg chondroitin sulfate and 45 mg quercetin glycosides per day) or placebo and the treatment and follow-up were continued for 16 weeks. The results of symptomatic efficacy assessment based on Japanese Orthopaedic Association criteria showed that scores for two of the four symptom/function subscales, as well as the aggregate scores, were significantly improved at week 16 or earlier in the GCQ group compared to the placebo group. Moreover, analyses of cartilage metabolism biomarkers showed a trend of improvement in type II collagen synthesis/degradation balance in the GCQ group during follow-up. CONCLUSION: GCQ supplement was thought to be more effective than placebo in decreasing the intensity of knee OA-associated clinical symptoms. SN - 1097-0010 UR - https://www.unboundmedicine.com/medline/citation/21969261/Effect_of_a_dietary_supplement_containing_glucosamine_hydrochloride_chondroitin_sulfate_and_quercetin_glycosides_on_symptomatic_knee_osteoarthritis:_a_randomized_double_blind_placebo_controlled_study_ L2 - https://doi.org/10.1002/jsfa.4660 DB - PRIME DP - Unbound Medicine ER -