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Chemopreventive potential of apigenin in 7,12-dimethylbenz(a)anthracene induced experimental oral carcinogenesis.
Eur J Pharmacol. 2011 Nov 30; 670(2-3):571-7.EJ

Abstract

Aim was to investigate the chemopreventive potential of apigenin by analyzing the tumor incidence as well as monitoring lipid peroxidation, antioxidants and phase I and phase II detoxification as biomarkers during DMBA induced hamster buccal pouch carcinogenesis. Oral tumors were developed in the buccal pouches of golden Syrian hamsters using topical application of 0.5% DMBA (DMBA) three times a week for 14weeks. Tumor incidence, tumor volume and burden were measured in hamsters treated with 7,12-dimethylbenz(a)anthracene and DMBA+apigenin (2.5mg/kg body weight) treated hamsters. Oral administration of apigenin not only completely prevented the formation of oral tumors, it also brought back the status of lipid peroxidation, antioxidants and phase I and phase II detoxification agents to near normal range during DMBA induced oral carcinogenesis. The present study thus concludes that apigenin might have inhibited oral carcinogenesis by improving the status of antioxidant defense mechanism and modulated the activities of phase I and phase II detoxification cascade toward increased excretion of active metabolite of DMBA, during DMBA induced hamster buccal pouch carcinogenesis.

Authors+Show Affiliations

Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu 608002, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21970806

Citation

Silvan, Simon, et al. "Chemopreventive Potential of Apigenin in 7,12-dimethylbenz(a)anthracene Induced Experimental Oral Carcinogenesis." European Journal of Pharmacology, vol. 670, no. 2-3, 2011, pp. 571-7.
Silvan S, Manoharan S, Baskaran N, et al. Chemopreventive potential of apigenin in 7,12-dimethylbenz(a)anthracene induced experimental oral carcinogenesis. Eur J Pharmacol. 2011;670(2-3):571-7.
Silvan, S., Manoharan, S., Baskaran, N., Anusuya, C., Karthikeyan, S., & Prabhakar, M. M. (2011). Chemopreventive potential of apigenin in 7,12-dimethylbenz(a)anthracene induced experimental oral carcinogenesis. European Journal of Pharmacology, 670(2-3), 571-7. https://doi.org/10.1016/j.ejphar.2011.09.179
Silvan S, et al. Chemopreventive Potential of Apigenin in 7,12-dimethylbenz(a)anthracene Induced Experimental Oral Carcinogenesis. Eur J Pharmacol. 2011 Nov 30;670(2-3):571-7. PubMed PMID: 21970806.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chemopreventive potential of apigenin in 7,12-dimethylbenz(a)anthracene induced experimental oral carcinogenesis. AU - Silvan,Simon, AU - Manoharan,Shanmugam, AU - Baskaran,Nagarethinam, AU - Anusuya,Chezhiyan, AU - Karthikeyan,Sekar, AU - Prabhakar,Murugaraj Manoj, Y1 - 2011/09/29/ PY - 2011/06/02/received PY - 2011/09/18/revised PY - 2011/09/19/accepted PY - 2011/10/6/entrez PY - 2011/10/6/pubmed PY - 2012/3/1/medline SP - 571 EP - 7 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 670 IS - 2-3 N2 - Aim was to investigate the chemopreventive potential of apigenin by analyzing the tumor incidence as well as monitoring lipid peroxidation, antioxidants and phase I and phase II detoxification as biomarkers during DMBA induced hamster buccal pouch carcinogenesis. Oral tumors were developed in the buccal pouches of golden Syrian hamsters using topical application of 0.5% DMBA (DMBA) three times a week for 14weeks. Tumor incidence, tumor volume and burden were measured in hamsters treated with 7,12-dimethylbenz(a)anthracene and DMBA+apigenin (2.5mg/kg body weight) treated hamsters. Oral administration of apigenin not only completely prevented the formation of oral tumors, it also brought back the status of lipid peroxidation, antioxidants and phase I and phase II detoxification agents to near normal range during DMBA induced oral carcinogenesis. The present study thus concludes that apigenin might have inhibited oral carcinogenesis by improving the status of antioxidant defense mechanism and modulated the activities of phase I and phase II detoxification cascade toward increased excretion of active metabolite of DMBA, during DMBA induced hamster buccal pouch carcinogenesis. SN - 1879-0712 UR - https://www.unboundmedicine.com/medline/citation/21970806/Chemopreventive_potential_of_apigenin_in_712_dimethylbenz_a_anthracene_induced_experimental_oral_carcinogenesis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(11)01162-9 DB - PRIME DP - Unbound Medicine ER -