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Poly(glycerol adipate)-fatty acid esters as versatile nanocarriers: From nanocubes over ellipsoids to nanospheres.
J Control Release. 2012 Feb 28; 158(1):156-64.JC

Abstract

Poly(glycerol adipate) (PGA) is a biodegradable polymer with promising features for nanoparticulate drug carrier systems. By acylation of PGA with fatty acids, composite systems with amphiphilic properties can be obtained. Variation of the fatty acid (laurate, stearate and behenate) and their substitution degrees lead to a wide range of different polymer structures. This strongly influences the aggregation of the polymer and thus the nature of the resulting colloidal system. Based on the modification of the interfacial deposition method, various self-stabilizing nanoparticles with defined sizes and narrow size distributions could be prepared. Non-spherical shapes (squares, pentagons) with an internal lamellar-like structure were observed for low substituted PGA-stearates. Higher substitution degrees lead to ellipsoidal or spherical particles. The size, charge, fluidity and polarity of the nanoparticles have been studied comprehensively by PCS, AF4, zeta potential measurements, DSC, NMR, TEM and fluorescence spectroscopy. The chain lengths of the attached fatty acids as well as their substitution degree substantially influence the physicochemical properties of the bulk polymers and the nanoparticles. With their diverse particle shapes and internal structures as well as their different thermal behavior, aggregate states and polarities, the systems offer promising possibilities as delivery systems for lipophilic, amphiphilic and water soluble drugs.

Authors+Show Affiliations

Institute of Pharmacy, Department of Pharmaceutical Technology and Biopharmacy, Martin Luther University Halle-Wittenberg, Wolfgang-Langenbeck-Str. 4, 06120 Halle (Saale), Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21971295

Citation

Weiss, Verena M., et al. "Poly(glycerol Adipate)-fatty Acid Esters as Versatile Nanocarriers: From Nanocubes Over Ellipsoids to Nanospheres." Journal of Controlled Release : Official Journal of the Controlled Release Society, vol. 158, no. 1, 2012, pp. 156-64.
Weiss VM, Naolou T, Hause G, et al. Poly(glycerol adipate)-fatty acid esters as versatile nanocarriers: From nanocubes over ellipsoids to nanospheres. J Control Release. 2012;158(1):156-64.
Weiss, V. M., Naolou, T., Hause, G., Kuntsche, J., Kressler, J., & Mäder, K. (2012). Poly(glycerol adipate)-fatty acid esters as versatile nanocarriers: From nanocubes over ellipsoids to nanospheres. Journal of Controlled Release : Official Journal of the Controlled Release Society, 158(1), 156-64. https://doi.org/10.1016/j.jconrel.2011.09.077
Weiss VM, et al. Poly(glycerol Adipate)-fatty Acid Esters as Versatile Nanocarriers: From Nanocubes Over Ellipsoids to Nanospheres. J Control Release. 2012 Feb 28;158(1):156-64. PubMed PMID: 21971295.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Poly(glycerol adipate)-fatty acid esters as versatile nanocarriers: From nanocubes over ellipsoids to nanospheres. AU - Weiss,Verena M, AU - Naolou,Toufik, AU - Hause,Gerd, AU - Kuntsche,Judith, AU - Kressler,Jörg, AU - Mäder,Karsten, Y1 - 2011/09/25/ PY - 2011/07/21/received PY - 2011/09/15/revised PY - 2011/09/18/accepted PY - 2011/10/6/entrez PY - 2011/10/6/pubmed PY - 2012/6/30/medline SP - 156 EP - 64 JF - Journal of controlled release : official journal of the Controlled Release Society JO - J Control Release VL - 158 IS - 1 N2 - Poly(glycerol adipate) (PGA) is a biodegradable polymer with promising features for nanoparticulate drug carrier systems. By acylation of PGA with fatty acids, composite systems with amphiphilic properties can be obtained. Variation of the fatty acid (laurate, stearate and behenate) and their substitution degrees lead to a wide range of different polymer structures. This strongly influences the aggregation of the polymer and thus the nature of the resulting colloidal system. Based on the modification of the interfacial deposition method, various self-stabilizing nanoparticles with defined sizes and narrow size distributions could be prepared. Non-spherical shapes (squares, pentagons) with an internal lamellar-like structure were observed for low substituted PGA-stearates. Higher substitution degrees lead to ellipsoidal or spherical particles. The size, charge, fluidity and polarity of the nanoparticles have been studied comprehensively by PCS, AF4, zeta potential measurements, DSC, NMR, TEM and fluorescence spectroscopy. The chain lengths of the attached fatty acids as well as their substitution degree substantially influence the physicochemical properties of the bulk polymers and the nanoparticles. With their diverse particle shapes and internal structures as well as their different thermal behavior, aggregate states and polarities, the systems offer promising possibilities as delivery systems for lipophilic, amphiphilic and water soluble drugs. SN - 1873-4995 UR - https://www.unboundmedicine.com/medline/citation/21971295/Poly_glycerol_adipate__fatty_acid_esters_as_versatile_nanocarriers:_From_nanocubes_over_ellipsoids_to_nanospheres_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-3659(11)00883-2 DB - PRIME DP - Unbound Medicine ER -