Tags

Type your tag names separated by a space and hit enter

From urgency to frequency: facts and controversies of TRPs in the lower urinary tract.
Nat Rev Urol. 2011 Oct 04; 8(11):617-30.NR

Abstract

The members of transient receptor potential (TRP) superfamily of cationic ion channels represent universal sensors, which convert multiple exogenous and endogenous chemical and physical stimuli into electrical and functional cellular responses. TRPs are widely distributed in many different tissues, and expression of numerous TRP types has been reported in lower urinary tract (LUT) tissues, neuronal fibers innervating the bladder and urethra, and epithelial and muscular layers of the bladder and urethral walls, where they are mainly involved in nociception and mechanosensory transduction. As such, they represent attractive targets for treating LUT disorders. Although information on the functional significance of many of the TRP proteins in the LUT remains very limited, compelling evidence has accumulated for a pivotal role of TRPV1, TRPV2, TRPV4, TRPM8, and TRPA1 in normal and pathological LUT function, mainly as sensors of stretch and chemical irritation. Further studies into these and other TRPs in the LUT will facilitate the development of improved therapeutic strategies to target these channels in LUT disorders.

Authors+Show Affiliations

Inserm, U1003, Laboratoire de Physiologie Cellulaire, Equipe labelisée par la Ligue contre le cancer, Villeneuve d'Ascq, F-59650 France. roman.skryma@univ-lille1.frNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

21971315

Citation

Skryma, Roman, et al. "From Urgency to Frequency: Facts and Controversies of TRPs in the Lower Urinary Tract." Nature Reviews. Urology, vol. 8, no. 11, 2011, pp. 617-30.
Skryma R, Prevarskaya N, Gkika D, et al. From urgency to frequency: facts and controversies of TRPs in the lower urinary tract. Nat Rev Urol. 2011;8(11):617-30.
Skryma, R., Prevarskaya, N., Gkika, D., & Shuba, Y. (2011). From urgency to frequency: facts and controversies of TRPs in the lower urinary tract. Nature Reviews. Urology, 8(11), 617-30. https://doi.org/10.1038/nrurol.2011.142
Skryma R, et al. From Urgency to Frequency: Facts and Controversies of TRPs in the Lower Urinary Tract. Nat Rev Urol. 2011 Oct 4;8(11):617-30. PubMed PMID: 21971315.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - From urgency to frequency: facts and controversies of TRPs in the lower urinary tract. AU - Skryma,Roman, AU - Prevarskaya,Natalia, AU - Gkika,Dimitra, AU - Shuba,Yaroslav, Y1 - 2011/10/04/ PY - 2011/10/6/entrez PY - 2011/10/6/pubmed PY - 2012/8/17/medline SP - 617 EP - 30 JF - Nature reviews. Urology JO - Nat Rev Urol VL - 8 IS - 11 N2 - The members of transient receptor potential (TRP) superfamily of cationic ion channels represent universal sensors, which convert multiple exogenous and endogenous chemical and physical stimuli into electrical and functional cellular responses. TRPs are widely distributed in many different tissues, and expression of numerous TRP types has been reported in lower urinary tract (LUT) tissues, neuronal fibers innervating the bladder and urethra, and epithelial and muscular layers of the bladder and urethral walls, where they are mainly involved in nociception and mechanosensory transduction. As such, they represent attractive targets for treating LUT disorders. Although information on the functional significance of many of the TRP proteins in the LUT remains very limited, compelling evidence has accumulated for a pivotal role of TRPV1, TRPV2, TRPV4, TRPM8, and TRPA1 in normal and pathological LUT function, mainly as sensors of stretch and chemical irritation. Further studies into these and other TRPs in the LUT will facilitate the development of improved therapeutic strategies to target these channels in LUT disorders. SN - 1759-4820 UR - https://www.unboundmedicine.com/medline/citation/21971315/From_urgency_to_frequency:_facts_and_controversies_of_TRPs_in_the_lower_urinary_tract_ L2 - https://doi.org/10.1038/nrurol.2011.142 DB - PRIME DP - Unbound Medicine ER -