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Fast 3D Near-infrared breast imaging using indocyanine green for detection and characterization of breast lesions.
Rofo. 2011 Oct; 183(10):956-63.ROFO

Abstract

PURPOSE

To evaluate fast 3D near-infrared breast imaging using the optical contrast agent indocyanine green (ICG) for the detection and characterization of breast lesions.

MATERIALS AND METHODS

30 patients with suspicious breast lesions on mammography and/or ultrasound underwent fast 2 Hz 3D optical mammography before, during, and after administration of a 25 mg ICG bolus prior to needle biopsy. The bolus kinetics is analyzed using two perfusion parameters and a derived parameter: "peak amplitude" (PA), "time-to-peak" (TTP) and "peak-time grouped amplitude" (PTA). A receiver operating characteristic curve (ROC) analysis was performed to define a PTA cut-off for reader-independent differentiation of benign and malignant lesions. 8 patients had to be excluded from data analysis. Overall 14 breasts bearing a malignant lesion, 8 breasts bearing a benign lesion and 3 healthy breasts were analyzed.

RESULTS

The cut-off-based PTA analysis allowed correct detection for 12 of 14 malignant lesions (tumor size: 8 - 80 mm; sensitivity = 85.7 %). Two malignant lesions were missed. In the benign study group only one fibroadenoma was detected (specificity = 87.5 %). The PTA values differed significantly between the benign group and the malignant group (Mann-Whitney U-test, p < 0.05). Breasts with malignant lesions showed higher peaks at early time-points in ICG perfusion.

CONCLUSION

Early perfusion analysis of ICG-enhanced 3D fast optical mammography revealed different enhancement patterns for benign and malignant lesions. This approach might help with the detection of malignant breast lesions and the differentiation from benign lesions.

Authors+Show Affiliations

Radiology, Charité Universitätsmedizin Berlin, Campus Virchow Klinikum.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

21972043

Citation

Schneider, P, et al. "Fast 3D Near-infrared Breast Imaging Using Indocyanine Green for Detection and Characterization of Breast Lesions." RoFo : Fortschritte Auf Dem Gebiete Der Rontgenstrahlen Und Der Nuklearmedizin, vol. 183, no. 10, 2011, pp. 956-63.
Schneider P, Piper S, Schmitz CH, et al. Fast 3D Near-infrared breast imaging using indocyanine green for detection and characterization of breast lesions. Rofo. 2011;183(10):956-63.
Schneider, P., Piper, S., Schmitz, C. H., Schreiter, N. F., Volkwein, N., Lüdemann, L., Malzahn, U., & Poellinger, A. (2011). Fast 3D Near-infrared breast imaging using indocyanine green for detection and characterization of breast lesions. RoFo : Fortschritte Auf Dem Gebiete Der Rontgenstrahlen Und Der Nuklearmedizin, 183(10), 956-63. https://doi.org/10.1055/s-0031-1281726
Schneider P, et al. Fast 3D Near-infrared Breast Imaging Using Indocyanine Green for Detection and Characterization of Breast Lesions. Rofo. 2011;183(10):956-63. PubMed PMID: 21972043.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fast 3D Near-infrared breast imaging using indocyanine green for detection and characterization of breast lesions. AU - Schneider,P, AU - Piper,S, AU - Schmitz,C H, AU - Schreiter,N F, AU - Volkwein,N, AU - Lüdemann,L, AU - Malzahn,U, AU - Poellinger,A, Y1 - 2011/10/04/ PY - 2011/10/6/entrez PY - 2011/10/6/pubmed PY - 2011/12/13/medline SP - 956 EP - 63 JF - RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin JO - Rofo VL - 183 IS - 10 N2 - PURPOSE: To evaluate fast 3D near-infrared breast imaging using the optical contrast agent indocyanine green (ICG) for the detection and characterization of breast lesions. MATERIALS AND METHODS: 30 patients with suspicious breast lesions on mammography and/or ultrasound underwent fast 2 Hz 3D optical mammography before, during, and after administration of a 25 mg ICG bolus prior to needle biopsy. The bolus kinetics is analyzed using two perfusion parameters and a derived parameter: "peak amplitude" (PA), "time-to-peak" (TTP) and "peak-time grouped amplitude" (PTA). A receiver operating characteristic curve (ROC) analysis was performed to define a PTA cut-off for reader-independent differentiation of benign and malignant lesions. 8 patients had to be excluded from data analysis. Overall 14 breasts bearing a malignant lesion, 8 breasts bearing a benign lesion and 3 healthy breasts were analyzed. RESULTS: The cut-off-based PTA analysis allowed correct detection for 12 of 14 malignant lesions (tumor size: 8 - 80 mm; sensitivity = 85.7 %). Two malignant lesions were missed. In the benign study group only one fibroadenoma was detected (specificity = 87.5 %). The PTA values differed significantly between the benign group and the malignant group (Mann-Whitney U-test, p < 0.05). Breasts with malignant lesions showed higher peaks at early time-points in ICG perfusion. CONCLUSION: Early perfusion analysis of ICG-enhanced 3D fast optical mammography revealed different enhancement patterns for benign and malignant lesions. This approach might help with the detection of malignant breast lesions and the differentiation from benign lesions. SN - 1438-9010 UR - https://www.unboundmedicine.com/medline/citation/21972043/Fast_3D_Near_infrared_breast_imaging_using_indocyanine_green_for_detection_and_characterization_of_breast_lesions_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0031-1281726 DB - PRIME DP - Unbound Medicine ER -