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Furan fatty acid as an anti-inflammatory component from the green-lipped mussel Perna canaliculus.
Proc Natl Acad Sci U S A. 2011 Oct 18; 108(42):17533-7.PN

Abstract

A lipid extract of Perna canaliculus (New Zealand green-lipped mussel) has reportedly displayed anti-inflammatory effects in animal models and in human controlled studies. However, the anti-inflammatory lipid components have not been investigated in detail due to the instability of the lipid extract, which has made the identification of the distinct active components a formidable task. Considering the instability of the active component, we carefully fractionated a lipid extract of Perna canaliculus (Lyprinol) and detected furan fatty acids (F-acids). These naturally but rarely detected fatty acids show potent radical-scavenging ability and are essential constituents of plants and algae. Based on these data, it has been proposed that F-acids could be potential antioxidants, which may contribute to the protective properties of fish and fish oil diets against chronic inflammatory diseases. However, to date, in vivo data to support the hypothesis have not been obtained, presumably due to the limited availability of F-acids. To confirm the in vivo anti-inflammatory effect of F-acids in comparison with that of eicosapentaenoic acid (EPA), we developed a semisynthetic preparation and examined its anti-inflammatory activity in a rat model of adjuvant-induced arthritis. Indeed, the F-acid ethyl ester exhibited more potent anti-inflammatory activity than that of the EPA ethyl ester. We report on the in vivo activity of F-acids, confirming that the lipid extract of the green-lipped mussel includes an unstable fatty acid that is more effective than EPA.

Authors+Show Affiliations

Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo 113-0033, Japan. wakimoto@mol.f.u-tokyo.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21972415

Citation

Wakimoto, Toshiyuki, et al. "Furan Fatty Acid as an Anti-inflammatory Component From the Green-lipped Mussel Perna Canaliculus." Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 42, 2011, pp. 17533-7.
Wakimoto T, Kondo H, Nii H, et al. Furan fatty acid as an anti-inflammatory component from the green-lipped mussel Perna canaliculus. Proc Natl Acad Sci USA. 2011;108(42):17533-7.
Wakimoto, T., Kondo, H., Nii, H., Kimura, K., Egami, Y., Oka, Y., Yoshida, M., Kida, E., Ye, Y., Akahoshi, S., Asakawa, T., Matsumura, K., Ishida, H., Nukaya, H., Tsuji, K., Kan, T., & Abe, I. (2011). Furan fatty acid as an anti-inflammatory component from the green-lipped mussel Perna canaliculus. Proceedings of the National Academy of Sciences of the United States of America, 108(42), 17533-7. https://doi.org/10.1073/pnas.1110577108
Wakimoto T, et al. Furan Fatty Acid as an Anti-inflammatory Component From the Green-lipped Mussel Perna Canaliculus. Proc Natl Acad Sci USA. 2011 Oct 18;108(42):17533-7. PubMed PMID: 21972415.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Furan fatty acid as an anti-inflammatory component from the green-lipped mussel Perna canaliculus. AU - Wakimoto,Toshiyuki, AU - Kondo,Hikaru, AU - Nii,Hirohiko, AU - Kimura,Kaori, AU - Egami,Yoko, AU - Oka,Yusuke, AU - Yoshida,Masae, AU - Kida,Eri, AU - Ye,Yiping, AU - Akahoshi,Saeko, AU - Asakawa,Tomohiro, AU - Matsumura,Koichi, AU - Ishida,Hitoshi, AU - Nukaya,Haruo, AU - Tsuji,Kuniro, AU - Kan,Toshiyuki, AU - Abe,Ikuro, Y1 - 2011/10/04/ PY - 2011/10/6/entrez PY - 2011/10/6/pubmed PY - 2011/12/31/medline SP - 17533 EP - 7 JF - Proceedings of the National Academy of Sciences of the United States of America JO - Proc. Natl. Acad. Sci. U.S.A. VL - 108 IS - 42 N2 - A lipid extract of Perna canaliculus (New Zealand green-lipped mussel) has reportedly displayed anti-inflammatory effects in animal models and in human controlled studies. However, the anti-inflammatory lipid components have not been investigated in detail due to the instability of the lipid extract, which has made the identification of the distinct active components a formidable task. Considering the instability of the active component, we carefully fractionated a lipid extract of Perna canaliculus (Lyprinol) and detected furan fatty acids (F-acids). These naturally but rarely detected fatty acids show potent radical-scavenging ability and are essential constituents of plants and algae. Based on these data, it has been proposed that F-acids could be potential antioxidants, which may contribute to the protective properties of fish and fish oil diets against chronic inflammatory diseases. However, to date, in vivo data to support the hypothesis have not been obtained, presumably due to the limited availability of F-acids. To confirm the in vivo anti-inflammatory effect of F-acids in comparison with that of eicosapentaenoic acid (EPA), we developed a semisynthetic preparation and examined its anti-inflammatory activity in a rat model of adjuvant-induced arthritis. Indeed, the F-acid ethyl ester exhibited more potent anti-inflammatory activity than that of the EPA ethyl ester. We report on the in vivo activity of F-acids, confirming that the lipid extract of the green-lipped mussel includes an unstable fatty acid that is more effective than EPA. SN - 1091-6490 UR - https://www.unboundmedicine.com/medline/citation/21972415/Furan_fatty_acid_as_an_anti_inflammatory_component_from_the_green_lipped_mussel_Perna_canaliculus_ L2 - http://www.pnas.org/cgi/pmidlookup?view=long&pmid=21972415 DB - PRIME DP - Unbound Medicine ER -