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[Effects of electroacupuncture on IL-2-IFN-NKC immunity immunoloregulation net and IL-2 receptor in rats with exercise stress].
Zhongguo Zhen Jiu. 2011 Sep; 31(9):817-20.ZZ

Abstract

OBJECTIVE

To explore the effects of electroacupuncture on exercise-induced immunosuppression in rats and its mechanism.

METHODS

Sports immunosuppressive model was established successfully by the rats were conducted high intensity swimming training 150 min/day, 6 days/wk for 8 weeks in this study. Forty-three SD rats were randomly divided into a control group (group A, n = 10), a high intensity swimming training group (group B, n = 17), and a high intensity plus electroacupuncture group (group C, n = 16). Group A did not receive any intervention. Group B was conducted 150 min/day, 6 days/wk swimming training for 8 weeks. Group C was treated with electroacupuncture at "Baihui" (GV 20), "Guanyuan" (CV 4) and "Zusanli" (ST 36) after every exercise-time from the second week, once each day for 7 weeks. The changes of the rats' weight, gamma-interferon (gamma-IFN), interleukin-2 (IL-2), solubility IL-2 receptor (SIL-2R) and nature killer cell (NKC) were detected.

RESULTS

(1) Compared with group A, gamma-IFN and IL-2 in group B were significantly decreased (P < 0.01, P < 0.05), and NKC in group C was significantly increased (P < 0.01). Meanwhile, gamma-IFN and NKC in group C were both significantly higher than that in group B (P < 0.05, P < 0.01). (2) Compared with group A, the weight of the rats in group B and group C were significantly decreased (both P < 0.01), but SIL-2R in group B was significantly increased (P < 0.05). The weight of the rats in group C was significantly higher than that in group B (P < 0.05) and SIL-2R in group C was significantly lower than that in group B (P < 0.01).

CONCLUSION

Lasting gravis exercise stress does decrease the immune function in rats and is even inhibited significantly, but electroacupuncture can up-regulate the exercise-induced immunosuppression.

Authors+Show Affiliations

Guangzhou University of TCM, Guangzhou 510405, Guangdong Province, China.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

21972636

Citation

Lu, Yong-Mei, et al. "[Effects of Electroacupuncture On IL-2-IFN-NKC Immunity Immunoloregulation Net and IL-2 Receptor in Rats With Exercise Stress]." Zhongguo Zhen Jiu = Chinese Acupuncture & Moxibustion, vol. 31, no. 9, 2011, pp. 817-20.
Lu YM, Zhang H, Tang CZ. [Effects of electroacupuncture on IL-2-IFN-NKC immunity immunoloregulation net and IL-2 receptor in rats with exercise stress]. Zhongguo Zhen Jiu. 2011;31(9):817-20.
Lu, Y. M., Zhang, H., & Tang, C. Z. (2011). [Effects of electroacupuncture on IL-2-IFN-NKC immunity immunoloregulation net and IL-2 receptor in rats with exercise stress]. Zhongguo Zhen Jiu = Chinese Acupuncture & Moxibustion, 31(9), 817-20.
Lu YM, Zhang H, Tang CZ. [Effects of Electroacupuncture On IL-2-IFN-NKC Immunity Immunoloregulation Net and IL-2 Receptor in Rats With Exercise Stress]. Zhongguo Zhen Jiu. 2011;31(9):817-20. PubMed PMID: 21972636.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of electroacupuncture on IL-2-IFN-NKC immunity immunoloregulation net and IL-2 receptor in rats with exercise stress]. AU - Lu,Yong-Mei, AU - Zhang,Hong, AU - Tang,Chun-Zhi, PY - 2011/10/7/entrez PY - 2011/10/7/pubmed PY - 2011/10/26/medline SP - 817 EP - 20 JF - Zhongguo zhen jiu = Chinese acupuncture & moxibustion JO - Zhongguo Zhen Jiu VL - 31 IS - 9 N2 - OBJECTIVE: To explore the effects of electroacupuncture on exercise-induced immunosuppression in rats and its mechanism. METHODS: Sports immunosuppressive model was established successfully by the rats were conducted high intensity swimming training 150 min/day, 6 days/wk for 8 weeks in this study. Forty-three SD rats were randomly divided into a control group (group A, n = 10), a high intensity swimming training group (group B, n = 17), and a high intensity plus electroacupuncture group (group C, n = 16). Group A did not receive any intervention. Group B was conducted 150 min/day, 6 days/wk swimming training for 8 weeks. Group C was treated with electroacupuncture at "Baihui" (GV 20), "Guanyuan" (CV 4) and "Zusanli" (ST 36) after every exercise-time from the second week, once each day for 7 weeks. The changes of the rats' weight, gamma-interferon (gamma-IFN), interleukin-2 (IL-2), solubility IL-2 receptor (SIL-2R) and nature killer cell (NKC) were detected. RESULTS: (1) Compared with group A, gamma-IFN and IL-2 in group B were significantly decreased (P < 0.01, P < 0.05), and NKC in group C was significantly increased (P < 0.01). Meanwhile, gamma-IFN and NKC in group C were both significantly higher than that in group B (P < 0.05, P < 0.01). (2) Compared with group A, the weight of the rats in group B and group C were significantly decreased (both P < 0.01), but SIL-2R in group B was significantly increased (P < 0.05). The weight of the rats in group C was significantly higher than that in group B (P < 0.05) and SIL-2R in group C was significantly lower than that in group B (P < 0.01). CONCLUSION: Lasting gravis exercise stress does decrease the immune function in rats and is even inhibited significantly, but electroacupuncture can up-regulate the exercise-induced immunosuppression. SN - 0255-2930 UR - https://www.unboundmedicine.com/medline/citation/21972636/[Effects_of_electroacupuncture_on_IL_2_IFN_NKC_immunity_immunoloregulation_net_and_IL_2_receptor_in_rats_with_exercise_stress]_ DB - PRIME DP - Unbound Medicine ER -