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Influence of catechol-o-methyltransferase genotype (Val158Met) on endocrine, sympathetic nervous and mucosal immune systems in breast cancer survivors.

Abstract

Stress can play an important role in development of cancer-related fatigue (CRF) by activating the hypothalamic-pituitary-adrenal (HPA) axis, the sympathetic nervous system (SNS), and altering the immune system. This study examined the influence of catechol-O-methyltransferase (COMT) Val158Met genotypes on salivary markers of HPA axis (cortisol), SNS (α-amylase) and immune (IgA) systems, as well as on CRF in breast cancer survivors (BCS). One-hundred BCS participated. After amplifying Val158Met COMT polymorphisms by polymerase chain reaction, three COMT genotypes were considered: Val/Val, Val/Met, Met/Met. Salivary cortisol, α-amylase activity, salivary flow rate, and IgA concentration were collected from non-stimulated saliva. CRF was assessed with the fatigue subscale of the Profile of Mood State (POMS) questionnaire. We found that BCS carrying Met/Met genotype reported higher cortisol concentration, α-amylase activity and greater CRF than those with Val/Met (P < 0.05) and Val/Val (P < 0.001) genotypes. No differences in salivary flow rate or IgA concentration (P > 0.20) were found. The results suggest that BCS carrying Met/Met genotype exhibit greater dysfunction of the HPA axis and SNS system associated with severe CRF. This study is important because it strives to understand biological factors that predispose some BCS to higher levels of CRF.

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  • Authors+Show Affiliations

    ,

    Department of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine, Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, Avenida de Atenas s/n, 28922 Alcorcón, Madrid, Spain. cesar.fernandez@urjc.es

    , , , , , ,

    Source

    Breast (Edinburgh, Scotland) 21:2 2012 Apr pg 199-203

    MeSH

    Adult
    Breast Neoplasms
    Catechol O-Methyltransferase
    Fatigue
    Female
    Genotype
    Humans
    Hydrocortisone
    Hypothalamo-Hypophyseal System
    Immunity, Mucosal
    Immunoglobulin A
    Middle Aged
    Pituitary-Adrenal System
    Saliva
    Stress, Psychological
    Survivors
    Sympathetic Nervous System
    alpha-Amylases

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21974969

    Citation

    Fernández-de-Las-Peñas, César, et al. "Influence of Catechol-o-methyltransferase Genotype (Val158Met) On Endocrine, Sympathetic Nervous and Mucosal Immune Systems in Breast Cancer Survivors." Breast (Edinburgh, Scotland), vol. 21, no. 2, 2012, pp. 199-203.
    Fernández-de-Las-Peñas C, Cantarero-Villanueva I, Fernández-Lao C, et al. Influence of catechol-o-methyltransferase genotype (Val158Met) on endocrine, sympathetic nervous and mucosal immune systems in breast cancer survivors. Breast. 2012;21(2):199-203.
    Fernández-de-Las-Peñas, C., Cantarero-Villanueva, I., Fernández-Lao, C., Ambite-Quesada, S., Díaz-Rodríguez, L., Rivas-Martínez, I., ... Arroyo-Morales, M. (2012). Influence of catechol-o-methyltransferase genotype (Val158Met) on endocrine, sympathetic nervous and mucosal immune systems in breast cancer survivors. Breast (Edinburgh, Scotland), 21(2), pp. 199-203. doi:10.1016/j.breast.2011.09.012.
    Fernández-de-Las-Peñas C, et al. Influence of Catechol-o-methyltransferase Genotype (Val158Met) On Endocrine, Sympathetic Nervous and Mucosal Immune Systems in Breast Cancer Survivors. Breast. 2012;21(2):199-203. PubMed PMID: 21974969.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Influence of catechol-o-methyltransferase genotype (Val158Met) on endocrine, sympathetic nervous and mucosal immune systems in breast cancer survivors. AU - Fernández-de-Las-Peñas,César, AU - Cantarero-Villanueva,Irene, AU - Fernández-Lao,Carolina, AU - Ambite-Quesada,Silvia, AU - Díaz-Rodríguez,Lourdes, AU - Rivas-Martínez,Inés, AU - del Moral-Avila,Rosario, AU - Arroyo-Morales,Manuel, Y1 - 2011/10/05/ PY - 2011/05/31/received PY - 2011/09/07/revised PY - 2011/09/15/accepted PY - 2011/10/7/entrez PY - 2011/10/7/pubmed PY - 2012/7/24/medline SP - 199 EP - 203 JF - Breast (Edinburgh, Scotland) JO - Breast VL - 21 IS - 2 N2 - Stress can play an important role in development of cancer-related fatigue (CRF) by activating the hypothalamic-pituitary-adrenal (HPA) axis, the sympathetic nervous system (SNS), and altering the immune system. This study examined the influence of catechol-O-methyltransferase (COMT) Val158Met genotypes on salivary markers of HPA axis (cortisol), SNS (α-amylase) and immune (IgA) systems, as well as on CRF in breast cancer survivors (BCS). One-hundred BCS participated. After amplifying Val158Met COMT polymorphisms by polymerase chain reaction, three COMT genotypes were considered: Val/Val, Val/Met, Met/Met. Salivary cortisol, α-amylase activity, salivary flow rate, and IgA concentration were collected from non-stimulated saliva. CRF was assessed with the fatigue subscale of the Profile of Mood State (POMS) questionnaire. We found that BCS carrying Met/Met genotype reported higher cortisol concentration, α-amylase activity and greater CRF than those with Val/Met (P < 0.05) and Val/Val (P < 0.001) genotypes. No differences in salivary flow rate or IgA concentration (P > 0.20) were found. The results suggest that BCS carrying Met/Met genotype exhibit greater dysfunction of the HPA axis and SNS system associated with severe CRF. This study is important because it strives to understand biological factors that predispose some BCS to higher levels of CRF. SN - 1532-3080 UR - https://www.unboundmedicine.com/medline/citation/21974969/Influence_of_catechol_o_methyltransferase_genotype__Val158Met__on_endocrine_sympathetic_nervous_and_mucosal_immune_systems_in_breast_cancer_survivors_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0960-9776(11)00336-5 DB - PRIME DP - Unbound Medicine ER -