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Neurophysiological functioning of occasional and heavy cannabis users during THC intoxication.

Abstract

RATIONALE

Experienced cannabis users demonstrate tolerance to some of the impairing acute effects of cannabis.

OBJECTIVES

The present study investigates whether event-related potentials (ERPs) differ between occasional and heavy cannabis users after acute Δ9-tetrahydrocannabinol (THC) administration, as a result of tolerance.

METHODS

Twelve occasional and 12 heavy cannabis users participated in a double-blind, placebo-controlled, crossover study. On two separate days, they smoked a joint containing 0 or 500 μg/kg body weight THC. ERPs were measured while subjects performed a divided attention task (DAT) and stop signal task (SST).

RESULTS

In the DAT, THC significantly decreased P100 amplitude in occasional but not in heavy cannabis users. P300 amplitude in the DAT was significantly decreased by THC in both groups. The N200 peak in the SST was not affected by treatment in neither of the groups. Performance in the SST was impaired in both groups after THC treatment, whereas performance in the DAT was impaired by THC only in the occasional users group.

CONCLUSIONS

The present study confirms that heavy cannabis users develop tolerance to some of the impairing behavioral effects of cannabis. This tolerance was also evident in the underlying ERPs, suggesting that tolerance demonstrated on performance level is not (completely) due to behavioral compensation.

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  • Authors+Show Affiliations

    ,

    Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, P.O. Box 616, 6200MD Maastricht, The Netherlands. e.theunissen@maastrichtuniversity.nl

    , , , , ,

    Source

    Psychopharmacology 220:2 2012 Mar pg 341-50

    MeSH

    Adult
    Attention
    Brain Waves
    Double-Blind Method
    Dronabinol
    Drug Tolerance
    Evoked Potentials
    Female
    Humans
    Inhibition (Psychology)
    Male
    Marijuana Abuse
    Psychomotor Performance

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21975580

    Citation

    Theunissen, Eef L., et al. "Neurophysiological Functioning of Occasional and Heavy Cannabis Users During THC Intoxication." Psychopharmacology, vol. 220, no. 2, 2012, pp. 341-50.
    Theunissen EL, Kauert GF, Toennes SW, et al. Neurophysiological functioning of occasional and heavy cannabis users during THC intoxication. Psychopharmacology (Berl). 2012;220(2):341-50.
    Theunissen, E. L., Kauert, G. F., Toennes, S. W., Moeller, M. R., Sambeth, A., Blanchard, M. M., & Ramaekers, J. G. (2012). Neurophysiological functioning of occasional and heavy cannabis users during THC intoxication. Psychopharmacology, 220(2), pp. 341-50. doi:10.1007/s00213-011-2479-x.
    Theunissen EL, et al. Neurophysiological Functioning of Occasional and Heavy Cannabis Users During THC Intoxication. Psychopharmacology (Berl). 2012;220(2):341-50. PubMed PMID: 21975580.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Neurophysiological functioning of occasional and heavy cannabis users during THC intoxication. AU - Theunissen,Eef L, AU - Kauert,Gerold F, AU - Toennes,Stefan W, AU - Moeller,Manfred R, AU - Sambeth,Anke, AU - Blanchard,Mathieu M, AU - Ramaekers,Johannes G, PY - 2011/04/21/received PY - 2011/08/31/accepted PY - 2011/10/7/entrez PY - 2011/10/7/pubmed PY - 2012/7/28/medline SP - 341 EP - 50 JF - Psychopharmacology JO - Psychopharmacology (Berl.) VL - 220 IS - 2 N2 - RATIONALE: Experienced cannabis users demonstrate tolerance to some of the impairing acute effects of cannabis. OBJECTIVES: The present study investigates whether event-related potentials (ERPs) differ between occasional and heavy cannabis users after acute Δ9-tetrahydrocannabinol (THC) administration, as a result of tolerance. METHODS: Twelve occasional and 12 heavy cannabis users participated in a double-blind, placebo-controlled, crossover study. On two separate days, they smoked a joint containing 0 or 500 μg/kg body weight THC. ERPs were measured while subjects performed a divided attention task (DAT) and stop signal task (SST). RESULTS: In the DAT, THC significantly decreased P100 amplitude in occasional but not in heavy cannabis users. P300 amplitude in the DAT was significantly decreased by THC in both groups. The N200 peak in the SST was not affected by treatment in neither of the groups. Performance in the SST was impaired in both groups after THC treatment, whereas performance in the DAT was impaired by THC only in the occasional users group. CONCLUSIONS: The present study confirms that heavy cannabis users develop tolerance to some of the impairing behavioral effects of cannabis. This tolerance was also evident in the underlying ERPs, suggesting that tolerance demonstrated on performance level is not (completely) due to behavioral compensation. SN - 1432-2072 UR - https://www.unboundmedicine.com/medline/citation/21975580/abstract/Neurophysiological_functioning_of_occasional_and_heavy_cannabis_users_during_THC_intoxication_ L2 - https://dx.doi.org/10.1007/s00213-011-2479-x DB - PRIME DP - Unbound Medicine ER -