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Modulation of excitability in human primary somatosensory and motor cortex by paired associative stimulation targeting the primary somatosensory cortex.
Eur J Neurosci. 2011 Oct; 34(8):1292-300.EJ

Abstract

Input from primary somatosensory cortex (S1) to primary motor cortex (M1) is important for high-level motor performance, motor skill learning and motor recovery after brain lesion. This study tested the effects of manipulating S1 excitability with paired associative transcranial stimulation (S1-PAS) on M1 excitability. Given the important role of S1 in sensorimotor integration, we hypothesized that changes in S1 excitability would be directly paralleled by changes in M1 excitability. We applied two established protocols (S1-PAS(LTP) and S1-PAS(LTD)) to the left S1 to induce long-term potentiation (LTP)-like or long-term depression (LTD)-like plasticity. S1 excitability was assessed by the early cortical components (N20-P25) of the median nerve somatosensory-evoked potential. M1 excitability was assessed by motor-evoked potential amplitude and short-interval intracortical inhibition. Effects of S1-PAS(LTP) were compared with those of a PAS(LTP) protocol targeting the left M1 (M1-PAS(LTP)). S1-PAS(LTP) and S1-PAS(LTD) did not result in significant modifications of S1 or M1 excitability at the group level due to substantial interindividual variability. The individual S1-PAS-induced changes in S1 and M1 excitability showed no correlation. Furthermore, the individual changes in S1 and M1 excitability induced by S1-PAS(LTP) did not correlate with changes in M1 excitability induced by M1-PAS(LTP) . This demonstrates that the effects of S1-PAS in S1 are variable across individuals and, within a given individual, unrelated to those induced by S1-PAS or M1-PAS in M1. Potentially, this extends the opportunities of therapeutic PAS applications because M1-PAS 'non-responders' may well respond to S1-PAS.

Authors+Show Affiliations

Motor Cortex Group, Department of Neurology, Goethe University of Frankfurt, Schleusenweg 2-16, Frankfurt am Main, Germany.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21978102

Citation

Kriváneková, Lucia, et al. "Modulation of Excitability in Human Primary Somatosensory and Motor Cortex By Paired Associative Stimulation Targeting the Primary Somatosensory Cortex." The European Journal of Neuroscience, vol. 34, no. 8, 2011, pp. 1292-300.
Kriváneková L, Lu MK, Bliem B, et al. Modulation of excitability in human primary somatosensory and motor cortex by paired associative stimulation targeting the primary somatosensory cortex. Eur J Neurosci. 2011;34(8):1292-300.
Kriváneková, L., Lu, M. K., Bliem, B., & Ziemann, U. (2011). Modulation of excitability in human primary somatosensory and motor cortex by paired associative stimulation targeting the primary somatosensory cortex. The European Journal of Neuroscience, 34(8), 1292-300. https://doi.org/10.1111/j.1460-9568.2011.07849.x
Kriváneková L, et al. Modulation of Excitability in Human Primary Somatosensory and Motor Cortex By Paired Associative Stimulation Targeting the Primary Somatosensory Cortex. Eur J Neurosci. 2011;34(8):1292-300. PubMed PMID: 21978102.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modulation of excitability in human primary somatosensory and motor cortex by paired associative stimulation targeting the primary somatosensory cortex. AU - Kriváneková,Lucia, AU - Lu,Ming-Kuei, AU - Bliem,Barbara, AU - Ziemann,Ulf, Y1 - 2011/10/06/ PY - 2011/10/8/entrez PY - 2011/10/8/pubmed PY - 2012/3/10/medline SP - 1292 EP - 300 JF - The European journal of neuroscience JO - Eur. J. Neurosci. VL - 34 IS - 8 N2 - Input from primary somatosensory cortex (S1) to primary motor cortex (M1) is important for high-level motor performance, motor skill learning and motor recovery after brain lesion. This study tested the effects of manipulating S1 excitability with paired associative transcranial stimulation (S1-PAS) on M1 excitability. Given the important role of S1 in sensorimotor integration, we hypothesized that changes in S1 excitability would be directly paralleled by changes in M1 excitability. We applied two established protocols (S1-PAS(LTP) and S1-PAS(LTD)) to the left S1 to induce long-term potentiation (LTP)-like or long-term depression (LTD)-like plasticity. S1 excitability was assessed by the early cortical components (N20-P25) of the median nerve somatosensory-evoked potential. M1 excitability was assessed by motor-evoked potential amplitude and short-interval intracortical inhibition. Effects of S1-PAS(LTP) were compared with those of a PAS(LTP) protocol targeting the left M1 (M1-PAS(LTP)). S1-PAS(LTP) and S1-PAS(LTD) did not result in significant modifications of S1 or M1 excitability at the group level due to substantial interindividual variability. The individual S1-PAS-induced changes in S1 and M1 excitability showed no correlation. Furthermore, the individual changes in S1 and M1 excitability induced by S1-PAS(LTP) did not correlate with changes in M1 excitability induced by M1-PAS(LTP) . This demonstrates that the effects of S1-PAS in S1 are variable across individuals and, within a given individual, unrelated to those induced by S1-PAS or M1-PAS in M1. Potentially, this extends the opportunities of therapeutic PAS applications because M1-PAS 'non-responders' may well respond to S1-PAS. SN - 1460-9568 UR - https://www.unboundmedicine.com/medline/citation/21978102/Modulation_of_excitability_in_human_primary_somatosensory_and_motor_cortex_by_paired_associative_stimulation_targeting_the_primary_somatosensory_cortex_ L2 - https://doi.org/10.1111/j.1460-9568.2011.07849.x DB - PRIME DP - Unbound Medicine ER -