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The modulation of catecholamines to the immune response against bacteria Vibrio anguillarum challenge in scallop Chlamys farreri.
Fish Shellfish Immunol. 2011 Dec; 31(6):1065-71.FS

Abstract

Catecholamines are pivotal signal molecules in the neuroendocrine-immune regulatory network, and implicated in the modulation of immune response. In the present study, the activities of some immune-related enzymes and the concentration of catecholamines were determined in circulating haemolymph of scallops Chlamys farreri after bacteria Vibrio anguillarum challenge. The activities of superoxide dismutase (SOD), catalase (CAT) and lysozyme (LYZ) increased significantly and reached 610 U mg(-1) at 12 h, 37.6 U mg(-1) at 6 h and 261.5 U mg(-1) at 6 h after bacteria challenge, respectively. The concentration of norepinephrine, epinephrine and dopamine also increased significantly and reached 114.9 ng mL(-1) at 12 h, 86.9 ng mL(-1) at 24 h and 480.4 pg mL(-1) at 12 h after bacteria challenge, respectively. Meanwhile, the activities of these immune-related enzymes in haemolymph were monitored in those scallops which were challenged by bacteria V. anguillarum and stimulated simultaneously with norepinephrine, epinephrine and adrenoceptor antagonist. The injection of norepinephrine and epinephrine repressed significantly the induction of bacteria challenge on the activities of immune-related enzymes, and they were reduced to about half of that in the control groups. The blocking of α and β-adrenoceptor by antagonist only repressed the increase of CAT and LYZ activities significantly, while no significant effect was observed on the increase of SOD activities. The collective results indicated that scallop catecholaminergic neuroendocrine system could be activated by bacteria challenge to release catecholamines after the immune response had been triggered, and the immune response against bacteria challenge could been negatively modulated by norepinephrine, epinephrine, and adrenoceptor antagonist. This information is helpful to further understand the immunomodulation of catecholamines in scallops.

Authors+Show Affiliations

Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, 7 Nanhai Rd., Qingdao 266071, Shandong, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21979298

Citation

Zhou, Zhi, et al. "The Modulation of Catecholamines to the Immune Response Against Bacteria Vibrio Anguillarum Challenge in Scallop Chlamys Farreri." Fish & Shellfish Immunology, vol. 31, no. 6, 2011, pp. 1065-71.
Zhou Z, Wang L, Shi X, et al. The modulation of catecholamines to the immune response against bacteria Vibrio anguillarum challenge in scallop Chlamys farreri. Fish Shellfish Immunol. 2011;31(6):1065-71.
Zhou, Z., Wang, L., Shi, X., Zhang, H., Gao, Y., Wang, M., Kong, P., Qiu, L., & Song, L. (2011). The modulation of catecholamines to the immune response against bacteria Vibrio anguillarum challenge in scallop Chlamys farreri. Fish & Shellfish Immunology, 31(6), 1065-71. https://doi.org/10.1016/j.fsi.2011.09.009
Zhou Z, et al. The Modulation of Catecholamines to the Immune Response Against Bacteria Vibrio Anguillarum Challenge in Scallop Chlamys Farreri. Fish Shellfish Immunol. 2011;31(6):1065-71. PubMed PMID: 21979298.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The modulation of catecholamines to the immune response against bacteria Vibrio anguillarum challenge in scallop Chlamys farreri. AU - Zhou,Zhi, AU - Wang,Lingling, AU - Shi,Xiaowei, AU - Zhang,Huan, AU - Gao,Yang, AU - Wang,Mengqiang, AU - Kong,Pengfei, AU - Qiu,Limei, AU - Song,Linsheng, Y1 - 2011/10/01/ PY - 2011/05/12/received PY - 2011/09/06/revised PY - 2011/09/09/accepted PY - 2011/10/8/entrez PY - 2011/10/8/pubmed PY - 2012/3/14/medline SP - 1065 EP - 71 JF - Fish & shellfish immunology JO - Fish Shellfish Immunol. VL - 31 IS - 6 N2 - Catecholamines are pivotal signal molecules in the neuroendocrine-immune regulatory network, and implicated in the modulation of immune response. In the present study, the activities of some immune-related enzymes and the concentration of catecholamines were determined in circulating haemolymph of scallops Chlamys farreri after bacteria Vibrio anguillarum challenge. The activities of superoxide dismutase (SOD), catalase (CAT) and lysozyme (LYZ) increased significantly and reached 610 U mg(-1) at 12 h, 37.6 U mg(-1) at 6 h and 261.5 U mg(-1) at 6 h after bacteria challenge, respectively. The concentration of norepinephrine, epinephrine and dopamine also increased significantly and reached 114.9 ng mL(-1) at 12 h, 86.9 ng mL(-1) at 24 h and 480.4 pg mL(-1) at 12 h after bacteria challenge, respectively. Meanwhile, the activities of these immune-related enzymes in haemolymph were monitored in those scallops which were challenged by bacteria V. anguillarum and stimulated simultaneously with norepinephrine, epinephrine and adrenoceptor antagonist. The injection of norepinephrine and epinephrine repressed significantly the induction of bacteria challenge on the activities of immune-related enzymes, and they were reduced to about half of that in the control groups. The blocking of α and β-adrenoceptor by antagonist only repressed the increase of CAT and LYZ activities significantly, while no significant effect was observed on the increase of SOD activities. The collective results indicated that scallop catecholaminergic neuroendocrine system could be activated by bacteria challenge to release catecholamines after the immune response had been triggered, and the immune response against bacteria challenge could been negatively modulated by norepinephrine, epinephrine, and adrenoceptor antagonist. This information is helpful to further understand the immunomodulation of catecholamines in scallops. SN - 1095-9947 UR - https://www.unboundmedicine.com/medline/citation/21979298/The_modulation_of_catecholamines_to_the_immune_response_against_bacteria_Vibrio_anguillarum_challenge_in_scallop_Chlamys_farreri_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1050-4648(11)00345-7 DB - PRIME DP - Unbound Medicine ER -