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Efficacy of metformin for prevention of weight gain in psychiatric populations: a review.
Int Clin Psychopharmacol. 2012 Mar; 27(2):69-75.IC

Abstract

There is uncertainty with regard to the appropriate use of metformin for the prevention and management of second-generation antipsychotic-induced weight gain and metabolic abnormalities. We aim to systematically review the primary literature and to provide recommendations with regard to the use of metformin in psychiatric populations prescribed second-generation antipsychotics. The authors undertook a literature search of Medline, EMBASE, and PsycINFO using the search terms; antipsychotic OR atypical antipsychotic AND weight AND metformin. Narrative review was undertaken without additional statistical analysis. The search provided 198 results from which 10 original research papers were identified: six randomized controlled trials and one open-label study for adults and two randomized controlled trials and one open-label study for children and adolescents. Four meta-analyses were also identified. We concluded that if weight gain occurs after second-generation antipsychotic initiation, despite lifestyle intervention, metformin should be considered. Further studies with adequate statistical power are required to determine the efficacy of metformin in those with chronic psychotic illness.

Authors+Show Affiliations

Faculty of Medicine, University of New South Wales, NSW, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

21979790

Citation

Newall, Hannah, et al. "Efficacy of Metformin for Prevention of Weight Gain in Psychiatric Populations: a Review." International Clinical Psychopharmacology, vol. 27, no. 2, 2012, pp. 69-75.
Newall H, Myles N, Ward PB, et al. Efficacy of metformin for prevention of weight gain in psychiatric populations: a review. Int Clin Psychopharmacol. 2012;27(2):69-75.
Newall, H., Myles, N., Ward, P. B., Samaras, K., Shiers, D., & Curtis, J. (2012). Efficacy of metformin for prevention of weight gain in psychiatric populations: a review. International Clinical Psychopharmacology, 27(2), 69-75. https://doi.org/10.1097/YIC.0b013e32834d0a5b
Newall H, et al. Efficacy of Metformin for Prevention of Weight Gain in Psychiatric Populations: a Review. Int Clin Psychopharmacol. 2012;27(2):69-75. PubMed PMID: 21979790.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of metformin for prevention of weight gain in psychiatric populations: a review. AU - Newall,Hannah, AU - Myles,Nicholas, AU - Ward,Philip B, AU - Samaras,Katherine, AU - Shiers,David, AU - Curtis,Jackie, PY - 2011/10/8/entrez PY - 2011/10/8/pubmed PY - 2012/6/5/medline SP - 69 EP - 75 JF - International clinical psychopharmacology JO - Int Clin Psychopharmacol VL - 27 IS - 2 N2 - There is uncertainty with regard to the appropriate use of metformin for the prevention and management of second-generation antipsychotic-induced weight gain and metabolic abnormalities. We aim to systematically review the primary literature and to provide recommendations with regard to the use of metformin in psychiatric populations prescribed second-generation antipsychotics. The authors undertook a literature search of Medline, EMBASE, and PsycINFO using the search terms; antipsychotic OR atypical antipsychotic AND weight AND metformin. Narrative review was undertaken without additional statistical analysis. The search provided 198 results from which 10 original research papers were identified: six randomized controlled trials and one open-label study for adults and two randomized controlled trials and one open-label study for children and adolescents. Four meta-analyses were also identified. We concluded that if weight gain occurs after second-generation antipsychotic initiation, despite lifestyle intervention, metformin should be considered. Further studies with adequate statistical power are required to determine the efficacy of metformin in those with chronic psychotic illness. SN - 1473-5857 UR - https://www.unboundmedicine.com/medline/citation/21979790/Efficacy_of_metformin_for_prevention_of_weight_gain_in_psychiatric_populations:_a_review_ L2 - https://doi.org/10.1097/YIC.0b013e32834d0a5b DB - PRIME DP - Unbound Medicine ER -