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Behavioral sensitization to 3,4-methylenedioxymethamphetamine is long-lasting and modulated by the context of drug administration.
Behav Pharmacol. 2011 Dec; 22(8):847-50.BP

Abstract

To begin to characterize the temporal profile of behavioral sensitization to the amphetamine derivative 3,4-methylenedioxymethamphetamine (MDMA), rats were treated with either saline or MDMA (5.0 mg/kg) twice daily for 5 days, followed by a challenge injection of MDMA (2.5 mg/kg) either 15 or 100 days later. Because we found previously that contextual drug associations are important for the expression of behavioral sensitization to MDMA following relatively short withdrawal periods, rats received the repeated injections either in their home cages (unpaired group) or in the activity monitors that were used for testing sensitization on challenge day (paired group). Locomotor sensitization was evident at 15 days of withdrawal but only in the paired MDMA-treated group. Interestingly, however, sensitization was apparent at 100 days of withdrawal in both paired and unpaired rats but the form of sensitization differed between groups. Thus, sensitization in paired rats was expressed as an increase in stereotypy, whereas sensitization in unpaired rats was expressed as an increase in locomotion, paralleling locomotion levels in paired animals at 15 days of withdrawal. These results suggest that the neural changes that underlie behavioral sensitization to MDMA are quite enduring but involve an interaction between withdrawal time and the context of drug administration.

Authors+Show Affiliations

Department of Psychology, Bloomsburg University of Pennsylvania, Bloomsburg, Pennsylvania 17815, USA. kball@bloomu.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

21979834

Citation

Ball, Kevin T., et al. "Behavioral Sensitization to 3,4-methylenedioxymethamphetamine Is Long-lasting and Modulated By the Context of Drug Administration." Behavioural Pharmacology, vol. 22, no. 8, 2011, pp. 847-50.
Ball KT, Klein JE, Plocinski JA, et al. Behavioral sensitization to 3,4-methylenedioxymethamphetamine is long-lasting and modulated by the context of drug administration. Behav Pharmacol. 2011;22(8):847-50.
Ball, K. T., Klein, J. E., Plocinski, J. A., & Slack, R. (2011). Behavioral sensitization to 3,4-methylenedioxymethamphetamine is long-lasting and modulated by the context of drug administration. Behavioural Pharmacology, 22(8), 847-50. https://doi.org/10.1097/FBP.0b013e32834d13b4
Ball KT, et al. Behavioral Sensitization to 3,4-methylenedioxymethamphetamine Is Long-lasting and Modulated By the Context of Drug Administration. Behav Pharmacol. 2011;22(8):847-50. PubMed PMID: 21979834.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Behavioral sensitization to 3,4-methylenedioxymethamphetamine is long-lasting and modulated by the context of drug administration. AU - Ball,Kevin T, AU - Klein,Jessalyn E, AU - Plocinski,Jacob A, AU - Slack,Rachel, PY - 2011/10/8/entrez PY - 2011/10/8/pubmed PY - 2013/2/6/medline SP - 847 EP - 50 JF - Behavioural pharmacology JO - Behav Pharmacol VL - 22 IS - 8 N2 - To begin to characterize the temporal profile of behavioral sensitization to the amphetamine derivative 3,4-methylenedioxymethamphetamine (MDMA), rats were treated with either saline or MDMA (5.0 mg/kg) twice daily for 5 days, followed by a challenge injection of MDMA (2.5 mg/kg) either 15 or 100 days later. Because we found previously that contextual drug associations are important for the expression of behavioral sensitization to MDMA following relatively short withdrawal periods, rats received the repeated injections either in their home cages (unpaired group) or in the activity monitors that were used for testing sensitization on challenge day (paired group). Locomotor sensitization was evident at 15 days of withdrawal but only in the paired MDMA-treated group. Interestingly, however, sensitization was apparent at 100 days of withdrawal in both paired and unpaired rats but the form of sensitization differed between groups. Thus, sensitization in paired rats was expressed as an increase in stereotypy, whereas sensitization in unpaired rats was expressed as an increase in locomotion, paralleling locomotion levels in paired animals at 15 days of withdrawal. These results suggest that the neural changes that underlie behavioral sensitization to MDMA are quite enduring but involve an interaction between withdrawal time and the context of drug administration. SN - 1473-5849 UR - https://www.unboundmedicine.com/medline/citation/21979834/Behavioral_sensitization_to_34_methylenedioxymethamphetamine_is_long_lasting_and_modulated_by_the_context_of_drug_administration_ L2 - http://dx.doi.org/10.1097/FBP.0b013e32834d13b4 DB - PRIME DP - Unbound Medicine ER -