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Folic acid supplementation in early pregnancy and asthma in children aged 6 years.
Am J Obstet Gynecol. 2012 Jan; 206(1):72.e1-7.AJ

Abstract

OBJECTIVE

The objective of the study was to assess whether folic acid intake during the first trimester of pregnancy is related to asthma in the offspring by the age of 6 years.

STUDY DESIGN

This was a prospective cohort study of 1499 women who were followed up from the first trimester of pregnancy. Their children were followed up until they were 6 years old.

RESULTS

Fifty-one percent of the women used folic acid in the month before conception and 88% in the third month of pregnancy. The adjusted odds ratio for asthma per 100 μm increase in the average daily intake of folic acid was 0.98 (95% confidence interval, 0.93-1.04). For categories of daily folate intake, there was no evidence of associations with childhood asthma or evidence of any dose response relation for any time period (all P(trend) > .05).

CONCLUSION

Our results do not support any association of folic acid supplementation in pregnancy and asthma risk in offspring by age 6 years.

Authors+Show Affiliations

Yale Center for Perinatal, Pediatric, and Environmental Epidemiology, Yale School of Public Health, New Haven, CT 06510, USA. michael.bracken@yale.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

21982024

Citation

Martinussen, Marit P., et al. "Folic Acid Supplementation in Early Pregnancy and Asthma in Children Aged 6 Years." American Journal of Obstetrics and Gynecology, vol. 206, no. 1, 2012, pp. 72.e1-7.
Martinussen MP, Risnes KR, Jacobsen GW, et al. Folic acid supplementation in early pregnancy and asthma in children aged 6 years. Am J Obstet Gynecol. 2012;206(1):72.e1-7.
Martinussen, M. P., Risnes, K. R., Jacobsen, G. W., & Bracken, M. B. (2012). Folic acid supplementation in early pregnancy and asthma in children aged 6 years. American Journal of Obstetrics and Gynecology, 206(1), e1-7. https://doi.org/10.1016/j.ajog.2011.07.033
Martinussen MP, et al. Folic Acid Supplementation in Early Pregnancy and Asthma in Children Aged 6 Years. Am J Obstet Gynecol. 2012;206(1):72.e1-7. PubMed PMID: 21982024.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Folic acid supplementation in early pregnancy and asthma in children aged 6 years. AU - Martinussen,Marit P, AU - Risnes,Kari R, AU - Jacobsen,Geir W, AU - Bracken,Michael B, Y1 - 2011/07/29/ PY - 2011/04/13/received PY - 2011/06/20/revised PY - 2011/07/22/accepted PY - 2011/10/11/entrez PY - 2011/10/11/pubmed PY - 2012/2/24/medline SP - 72.e1 EP - 7 JF - American journal of obstetrics and gynecology JO - Am J Obstet Gynecol VL - 206 IS - 1 N2 - OBJECTIVE: The objective of the study was to assess whether folic acid intake during the first trimester of pregnancy is related to asthma in the offspring by the age of 6 years. STUDY DESIGN: This was a prospective cohort study of 1499 women who were followed up from the first trimester of pregnancy. Their children were followed up until they were 6 years old. RESULTS: Fifty-one percent of the women used folic acid in the month before conception and 88% in the third month of pregnancy. The adjusted odds ratio for asthma per 100 μm increase in the average daily intake of folic acid was 0.98 (95% confidence interval, 0.93-1.04). For categories of daily folate intake, there was no evidence of associations with childhood asthma or evidence of any dose response relation for any time period (all P(trend) > .05). CONCLUSION: Our results do not support any association of folic acid supplementation in pregnancy and asthma risk in offspring by age 6 years. SN - 1097-6868 UR - https://www.unboundmedicine.com/medline/citation/21982024/Folic_acid_supplementation_in_early_pregnancy_and_asthma_in_children_aged_6_years_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9378(11)00950-1 DB - PRIME DP - Unbound Medicine ER -