Tags

Type your tag names separated by a space and hit enter

What defines extraintestinal pathogenic Escherichia coli?
Int J Med Microbiol. 2011 Dec; 301(8):642-7.IJ

Abstract

Escherichia coli (E. coli) exhibits considerable physiological and metabolic versatility and includes a variety of non-pathogenic, commensal variants, which belong to the normal gut flora of humans and warm-blooded animals. Additionally, several pathogenic variants have been identified which cause various types of intestinal or extraintestinal infections in humans and animals. In contrast to intestinal pathogenic E. coli (IPEC), which are obligate pathogens, extraintestinal pathogenic E. coli (ExPEC) are facultative pathogens which belong to the normal gut flora of a certain fraction of the healthy population where they live as commensals. Comparative genomics and epidemiological studies have been applied to study genomic diversity, markers, and phenotypic traits that may support discrimination of different E. coli pathotypes. Whereas IPEC are often epidemiologically and phylogenetically distinct from ExPEC and non-pathogenic, commensal strains, many ExPEC and non-pathogenic E. coli share large genomic fractions. Furthermore, extraintestinal infections of elderly or immunocompromised patients can be caused by E. coli variants which differ in their geno- and phenotypes from archetypal ExPEC. Thus, strain typing based on the detection of a limited number of ExPEC virulence/fitness-related genes may be ambiguous. A limited number of ExPEC-dominated clonal complexes can be identified in the E. coli population by multi locus sequence typing. Nevertheless, ExPEC and non-pathogenic E. coli cannot be clearly discriminated by molecular epidemiological approaches. Increased knowledge of the phylogeny, virulence and fitness traits, and host factors contributing to host susceptibility of the different groups of ExPEC variants is required for a better understanding of the biological basis of ExPEC infections.

Authors+Show Affiliations

Institute for Hygiene, University of Münster, Robert-Koch-Str. 41, 48149 Münster, Germany.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

21982038

Citation

Köhler, Christian-Daniel, and Ulrich Dobrindt. "What Defines Extraintestinal Pathogenic Escherichia Coli?" International Journal of Medical Microbiology : IJMM, vol. 301, no. 8, 2011, pp. 642-7.
Köhler CD, Dobrindt U. What defines extraintestinal pathogenic Escherichia coli? Int J Med Microbiol. 2011;301(8):642-7.
Köhler, C. D., & Dobrindt, U. (2011). What defines extraintestinal pathogenic Escherichia coli? International Journal of Medical Microbiology : IJMM, 301(8), 642-7. https://doi.org/10.1016/j.ijmm.2011.09.006
Köhler CD, Dobrindt U. What Defines Extraintestinal Pathogenic Escherichia Coli. Int J Med Microbiol. 2011;301(8):642-7. PubMed PMID: 21982038.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - What defines extraintestinal pathogenic Escherichia coli? AU - Köhler,Christian-Daniel, AU - Dobrindt,Ulrich, Y1 - 2011/10/05/ PY - 2011/10/11/entrez PY - 2011/10/11/pubmed PY - 2012/2/23/medline SP - 642 EP - 7 JF - International journal of medical microbiology : IJMM JO - Int J Med Microbiol VL - 301 IS - 8 N2 - Escherichia coli (E. coli) exhibits considerable physiological and metabolic versatility and includes a variety of non-pathogenic, commensal variants, which belong to the normal gut flora of humans and warm-blooded animals. Additionally, several pathogenic variants have been identified which cause various types of intestinal or extraintestinal infections in humans and animals. In contrast to intestinal pathogenic E. coli (IPEC), which are obligate pathogens, extraintestinal pathogenic E. coli (ExPEC) are facultative pathogens which belong to the normal gut flora of a certain fraction of the healthy population where they live as commensals. Comparative genomics and epidemiological studies have been applied to study genomic diversity, markers, and phenotypic traits that may support discrimination of different E. coli pathotypes. Whereas IPEC are often epidemiologically and phylogenetically distinct from ExPEC and non-pathogenic, commensal strains, many ExPEC and non-pathogenic E. coli share large genomic fractions. Furthermore, extraintestinal infections of elderly or immunocompromised patients can be caused by E. coli variants which differ in their geno- and phenotypes from archetypal ExPEC. Thus, strain typing based on the detection of a limited number of ExPEC virulence/fitness-related genes may be ambiguous. A limited number of ExPEC-dominated clonal complexes can be identified in the E. coli population by multi locus sequence typing. Nevertheless, ExPEC and non-pathogenic E. coli cannot be clearly discriminated by molecular epidemiological approaches. Increased knowledge of the phylogeny, virulence and fitness traits, and host factors contributing to host susceptibility of the different groups of ExPEC variants is required for a better understanding of the biological basis of ExPEC infections. SN - 1618-0607 UR - https://www.unboundmedicine.com/medline/citation/21982038/What_defines_extraintestinal_pathogenic_Escherichia_coli L2 - https://linkinghub.elsevier.com/retrieve/pii/S1438-4221(11)00092-0 DB - PRIME DP - Unbound Medicine ER -