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Vitamin A palmitate and α-lipoic acid stability in o/w emulsions for cosmetic application.
J Cosmet Sci. 2011 Jul-Aug; 62(4):405-15.JC

Abstract

Skin becomes thin, dry, pale, and finely wrinkled with age. Retinoids are a large class of compounds that are important in modern therapy for dermatological treatment of wrinkled skin. Of the retinoids, retinol and vitamin A palmitate are thought to induce thickening of the epidermis and to be effective for treatment of skin diseases. Accordingly, α-lipoic acid or the reduced form, dihydrolipoate, are potent scavengers of hydroxyl radicals, superoxide radicals, peroxyl radicals, singlet oxygen, and nitric oxide with anti-inflammatory properties (1). Cosmetic ingredient stability prediction relies on kinetic quantitative chemical analysis of active components at different temperatures. Vitamin A palmitate and α-lipoic acid, are known to be unstable to light or heat (2). The aims of this study were to evaluate the stability of α-lipoic acid and vitamin A palmitate in the presence of vitamin E (acetate) and other antioxidants in lipophilic/hydrophilic medium (O/W emulsions) at pH 3.0, 5.0, and 7.0. The formulations that were investigated contained 0.12% (w/w) vitamin A palmitate, 0.4% (w/w) vitamin E acetate, and 0.5 % α-lipoic acid (formulation A), supplemented with ascorbyl palmitate, magnesium ascorbyl phosphate, and vitamin C (formulation B) or with butylhydroxytoluene (BHT, formulation C) or ascorbyl palmitate (formulation D). The chemical analyses of α-lipoic acid and vitamin A palmitate were carried out by HPLC. Formulations C and D at pH 7.0 were selected as the most stable for these components. The purpose of this paper is the selection of the most stable formulations for their application in in vivo studies.

Authors+Show Affiliations

Cátedra de Control de Calidad de Medicamentos, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956, 1113 Buenos Aires, Argentina.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21982355

Citation

Moyano, M A., and A Segall. "Vitamin a Palmitate and Α-lipoic Acid Stability in O/w Emulsions for Cosmetic Application." Journal of Cosmetic Science, vol. 62, no. 4, 2011, pp. 405-15.
Moyano MA, Segall A. Vitamin A palmitate and α-lipoic acid stability in o/w emulsions for cosmetic application. J Cosmet Sci. 2011;62(4):405-15.
Moyano, M. A., & Segall, A. (2011). Vitamin A palmitate and α-lipoic acid stability in o/w emulsions for cosmetic application. Journal of Cosmetic Science, 62(4), 405-15.
Moyano MA, Segall A. Vitamin a Palmitate and Α-lipoic Acid Stability in O/w Emulsions for Cosmetic Application. J Cosmet Sci. 2011 Jul-Aug;62(4):405-15. PubMed PMID: 21982355.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin A palmitate and α-lipoic acid stability in o/w emulsions for cosmetic application. AU - Moyano,M A, AU - Segall,A, PY - 2011/02/28/accepted PY - 2011/10/11/entrez PY - 2011/10/11/pubmed PY - 2011/12/13/medline SP - 405 EP - 15 JF - Journal of cosmetic science JO - J Cosmet Sci VL - 62 IS - 4 N2 - Skin becomes thin, dry, pale, and finely wrinkled with age. Retinoids are a large class of compounds that are important in modern therapy for dermatological treatment of wrinkled skin. Of the retinoids, retinol and vitamin A palmitate are thought to induce thickening of the epidermis and to be effective for treatment of skin diseases. Accordingly, α-lipoic acid or the reduced form, dihydrolipoate, are potent scavengers of hydroxyl radicals, superoxide radicals, peroxyl radicals, singlet oxygen, and nitric oxide with anti-inflammatory properties (1). Cosmetic ingredient stability prediction relies on kinetic quantitative chemical analysis of active components at different temperatures. Vitamin A palmitate and α-lipoic acid, are known to be unstable to light or heat (2). The aims of this study were to evaluate the stability of α-lipoic acid and vitamin A palmitate in the presence of vitamin E (acetate) and other antioxidants in lipophilic/hydrophilic medium (O/W emulsions) at pH 3.0, 5.0, and 7.0. The formulations that were investigated contained 0.12% (w/w) vitamin A palmitate, 0.4% (w/w) vitamin E acetate, and 0.5 % α-lipoic acid (formulation A), supplemented with ascorbyl palmitate, magnesium ascorbyl phosphate, and vitamin C (formulation B) or with butylhydroxytoluene (BHT, formulation C) or ascorbyl palmitate (formulation D). The chemical analyses of α-lipoic acid and vitamin A palmitate were carried out by HPLC. Formulations C and D at pH 7.0 were selected as the most stable for these components. The purpose of this paper is the selection of the most stable formulations for their application in in vivo studies. SN - 1525-7886 UR - https://www.unboundmedicine.com/medline/citation/21982355/Vitamin_A_palmitate_and_α_lipoic_acid_stability_in_o/w_emulsions_for_cosmetic_application_ L2 - https://medlineplus.gov/cosmetics.html DB - PRIME DP - Unbound Medicine ER -