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Abnormal ventilatory control in Parkinson's disease--further evidence for non-motor dysfunction.
Respir Physiol Neurobiol. 2011 Dec 15; 179(2-3):300-4.RP

Abstract

There has been increasing recognition of pre-motor manifestations of Parkinson's disease (PD) resulting from early brainstem involvement. We sought to determine whether ventilatory control is abnormal. Patients with PD without respiratory disease were recruited. Spirometry, lung volumes, diffusing capacity and respiratory muscle strength were assessed. Occlusion pressure and ventilation were measured with increasing CO(2). Arterial blood gases were taken at rest and following 20 min exposure to 15% O(2). A linear correlation assessed associations between respiratory function and indices of PD severity. 19 subjects (17 males) with mild-moderate PD were studied (mean (SD) age 66 (8) years). Respiratory flows and volumes were normal in 16/19. Maximum inspiratory and expiratory pressures were below LLN in 13/19 and 15/19 respectively. 7/15 had a reduced ventilatory response to hypercapnia and 11/15 had an abnormal occlusion pressure. There was no correlation between impairment of ventilatory response and reduction in respiratory muscle strength. Response to mild hypoxia was normal and there were no associations between disease severity and respiratory function. Our findings suggest that patients with mild-moderate PD have abnormal ventilatory control despite normal lung volumes and flows.

Authors+Show Affiliations

Department of Thoracic Medicine, Concord Repatriation General Hospital, Sydney, NSW, Australia. leigh.seccombe@sswahs.nsw.gov.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21982817

Citation

Seccombe, Leigh M., et al. "Abnormal Ventilatory Control in Parkinson's Disease--further Evidence for Non-motor Dysfunction." Respiratory Physiology & Neurobiology, vol. 179, no. 2-3, 2011, pp. 300-4.
Seccombe LM, Giddings HL, Rogers PG, et al. Abnormal ventilatory control in Parkinson's disease--further evidence for non-motor dysfunction. Respir Physiol Neurobiol. 2011;179(2-3):300-4.
Seccombe, L. M., Giddings, H. L., Rogers, P. G., Corbett, A. J., Hayes, M. W., Peters, M. J., & Veitch, E. M. (2011). Abnormal ventilatory control in Parkinson's disease--further evidence for non-motor dysfunction. Respiratory Physiology & Neurobiology, 179(2-3), 300-4. https://doi.org/10.1016/j.resp.2011.09.012
Seccombe LM, et al. Abnormal Ventilatory Control in Parkinson's Disease--further Evidence for Non-motor Dysfunction. Respir Physiol Neurobiol. 2011 Dec 15;179(2-3):300-4. PubMed PMID: 21982817.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Abnormal ventilatory control in Parkinson's disease--further evidence for non-motor dysfunction. AU - Seccombe,Leigh M, AU - Giddings,Hugh L, AU - Rogers,Peter G, AU - Corbett,Alastair J, AU - Hayes,Michael W, AU - Peters,Matthew J, AU - Veitch,Elizabeth M, Y1 - 2011/09/29/ PY - 2011/07/26/received PY - 2011/09/02/revised PY - 2011/09/21/accepted PY - 2011/10/11/entrez PY - 2011/10/11/pubmed PY - 2012/6/13/medline SP - 300 EP - 4 JF - Respiratory physiology & neurobiology JO - Respir Physiol Neurobiol VL - 179 IS - 2-3 N2 - There has been increasing recognition of pre-motor manifestations of Parkinson's disease (PD) resulting from early brainstem involvement. We sought to determine whether ventilatory control is abnormal. Patients with PD without respiratory disease were recruited. Spirometry, lung volumes, diffusing capacity and respiratory muscle strength were assessed. Occlusion pressure and ventilation were measured with increasing CO(2). Arterial blood gases were taken at rest and following 20 min exposure to 15% O(2). A linear correlation assessed associations between respiratory function and indices of PD severity. 19 subjects (17 males) with mild-moderate PD were studied (mean (SD) age 66 (8) years). Respiratory flows and volumes were normal in 16/19. Maximum inspiratory and expiratory pressures were below LLN in 13/19 and 15/19 respectively. 7/15 had a reduced ventilatory response to hypercapnia and 11/15 had an abnormal occlusion pressure. There was no correlation between impairment of ventilatory response and reduction in respiratory muscle strength. Response to mild hypoxia was normal and there were no associations between disease severity and respiratory function. Our findings suggest that patients with mild-moderate PD have abnormal ventilatory control despite normal lung volumes and flows. SN - 1878-1519 UR - https://www.unboundmedicine.com/medline/citation/21982817/Abnormal_ventilatory_control_in_Parkinson's_disease__further_evidence_for_non_motor_dysfunction_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1569-9048(11)00346-6 DB - PRIME DP - Unbound Medicine ER -