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Effect of etomidate versus thiopental on major depressive disorder in electroconvulsive therapy, a randomized double-blind controlled clinical trial.
J ECT. 2012 Mar; 28(1):10-3.JE

Abstract

BACKGROUND

Although the therapeutic effect of electroconvulsive therapy (ECT) on major depressive disorder is widely investigated, there is a gap in literature regarding the possible effects of the medications used for induction of anesthesia in ECT. To the best of the authors' knowledge, this study is the first randomized double-blind clinical trial comparing the effect of etomidate and sodium thiopental on the depression symptoms in patients who have received ECT.

METHODS

The participants of this study are 60 adult patients with major depressive disorder who were referred for ECT. They were randomly allocated into 1 of the 2 groups. One group received etomidate, and the other group received sodium thiopental, as medication for induction of anesthesia. All the patients received bilateral ECT. The outcomes measures included the Beck Depression Inventory score, seizure duration, and recovery duration after induction of anesthesia.

RESULTS

The sex ratio and mean age were not different between the 2 groups. Linear regression analysis showed that etomidate decreased the depression score more than did sodium thiopental. Seizure duration in all of the sessions in the etomidate group was significantly higher than that of sodium thiopental group.

CONCLUSIONS

In conclusion, etomidate may improve major depressive disorder more than sodium thiopental in patients who are receiving ECT.

Authors+Show Affiliations

Anesthesiology Department, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

21983758

Citation

Abdollahi, Mohammad Hassan, et al. "Effect of Etomidate Versus Thiopental On Major Depressive Disorder in Electroconvulsive Therapy, a Randomized Double-blind Controlled Clinical Trial." The Journal of ECT, vol. 28, no. 1, 2012, pp. 10-3.
Abdollahi MH, Izadi A, Hajiesmaeili MR, et al. Effect of etomidate versus thiopental on major depressive disorder in electroconvulsive therapy, a randomized double-blind controlled clinical trial. J ECT. 2012;28(1):10-3.
Abdollahi, M. H., Izadi, A., Hajiesmaeili, M. R., Ghanizadeh, A., Dastjerdi, G., Hosseini, H. A., Ghiamat, M. M., & Abbasi, H. R. (2012). Effect of etomidate versus thiopental on major depressive disorder in electroconvulsive therapy, a randomized double-blind controlled clinical trial. The Journal of ECT, 28(1), 10-3. https://doi.org/10.1097/YCT.0b013e31822a6b8e
Abdollahi MH, et al. Effect of Etomidate Versus Thiopental On Major Depressive Disorder in Electroconvulsive Therapy, a Randomized Double-blind Controlled Clinical Trial. J ECT. 2012;28(1):10-3. PubMed PMID: 21983758.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of etomidate versus thiopental on major depressive disorder in electroconvulsive therapy, a randomized double-blind controlled clinical trial. AU - Abdollahi,Mohammad Hassan, AU - Izadi,Amir, AU - Hajiesmaeili,Mohammad Reza, AU - Ghanizadeh,Ahmad, AU - Dastjerdi,Ghasem, AU - Hosseini,Habib Allah, AU - Ghiamat,Mohammad Mehdi, AU - Abbasi,Hamid Reza, PY - 2011/10/11/entrez PY - 2011/10/11/pubmed PY - 2012/6/13/medline SP - 10 EP - 3 JF - The journal of ECT JO - J ECT VL - 28 IS - 1 N2 - BACKGROUND: Although the therapeutic effect of electroconvulsive therapy (ECT) on major depressive disorder is widely investigated, there is a gap in literature regarding the possible effects of the medications used for induction of anesthesia in ECT. To the best of the authors' knowledge, this study is the first randomized double-blind clinical trial comparing the effect of etomidate and sodium thiopental on the depression symptoms in patients who have received ECT. METHODS: The participants of this study are 60 adult patients with major depressive disorder who were referred for ECT. They were randomly allocated into 1 of the 2 groups. One group received etomidate, and the other group received sodium thiopental, as medication for induction of anesthesia. All the patients received bilateral ECT. The outcomes measures included the Beck Depression Inventory score, seizure duration, and recovery duration after induction of anesthesia. RESULTS: The sex ratio and mean age were not different between the 2 groups. Linear regression analysis showed that etomidate decreased the depression score more than did sodium thiopental. Seizure duration in all of the sessions in the etomidate group was significantly higher than that of sodium thiopental group. CONCLUSIONS: In conclusion, etomidate may improve major depressive disorder more than sodium thiopental in patients who are receiving ECT. SN - 1533-4112 UR - https://www.unboundmedicine.com/medline/citation/21983758/Effect_of_etomidate_versus_thiopental_on_major_depressive_disorder_in_electroconvulsive_therapy_a_randomized_double_blind_controlled_clinical_trial_ L2 - https://doi.org/10.1097/YCT.0b013e31822a6b8e DB - PRIME DP - Unbound Medicine ER -