TY - JOUR T1 - Comparison of efficacy of letrozole and clomiphene citrate in ovulation induction in Indian women with polycystic ovarian syndrome. AU - Banerjee Ray,Payal, AU - Ray,Amitabh, AU - Chakraborti,P S, Y1 - 2011/10/07/ PY - 2011/05/31/received PY - 2011/09/12/accepted PY - 2011/10/11/entrez PY - 2011/10/11/pubmed PY - 2012/7/3/medline SP - 873 EP - 7 JF - Archives of gynecology and obstetrics JO - Arch Gynecol Obstet VL - 285 IS - 3 N2 - OBJECTIVES: The objective of this study was to compare the efficacy of letrozole versus clomiphene citrate as an ovulation induction drug in polycystic ovarian syndrome (PCOS) patients of Indian origin. METHOD: One hundred and forty seven infertile PCOS patients were randomly given letrozole (2.5 mg) (n = 69) or clomiphene (100 mg) (n = 78) from day 3 to day 7 of menstrual cycle, followed-up with transvaginal serial folliculometry from day 9. 10,000 IU of human chorionic gonadotropin (hCG) was administered when at least 1 ovarian follicle was ≥ 18 mm in size. RESULTS: The pertinent results of the study are as follows: on the day of hCG injection, mean E2 level was significantly higher in the clomphene citrate group (817 ± 286.70 pg/ml) in comparison with letrozole group (444.03 ± 85.42 pg/ml). Mean endometrial development was 8.72 ± 1.41 mm in the letrozole and 8.78 ± 1.16 mm in the clomiphene group (P = 0.004). CONCLUSION: Letrozole has beneficial effect on endometrium, thereby potentially increasing pregnancy rates after successful ovulation induction in women with PCOS. SN - 1432-0711 UR - https://www.unboundmedicine.com/medline/citation/21984038/Comparison_of_efficacy_of_letrozole_and_clomiphene_citrate_in_ovulation_induction_in_Indian_women_with_polycystic_ovarian_syndrome_ L2 - https://dx.doi.org/10.1007/s00404-011-2091-7 DB - PRIME DP - Unbound Medicine ER -