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Indoloquinazoline alkaloids from Euodia rutaecarpa and their cytotoxic activities.
J Asian Nat Prod Res. 2011 Oct; 13(11):977-83.JA

Abstract

Nine indoloquinazoline alkaloids (1-9) were isolated from the dried and nearly ripe fruits of Euodia rutaecarpa (Juss.) Benth. (Euodiae Fructus), along with limonin and β-sitosterol. Their structures were elucidated on the basis of their spectroscopic data. Among them, compounds 1 and 2 were new compounds and characterized as (7R,8S)-7-hydroxy-8-methoxy-rutaecarpine and (7R,8S)-7-hydroxy-8-ethoxy-rutaecarpine, respectively, and 1-hydroxy-rutaecarpine (3) and (7R,8S)-7,8-dihydroxy-rutaecarpine (4) were isolated from Euodiae Fructus for the first time. The nine indoloquinazoline alkaloids were evaluated for their cytotoxic activities against human promyelocytic leukemia HL-60 cells and human gastric carcinoma N-87 cells.

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Authors+Show Affiliations

Huang X
State Key Laboratory of Natural and Biomimetic Drugs (Peking University), Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
Zhang YB
No affiliation info available
Yang XW
No affiliation info available

MeSH

AlkaloidsAntineoplastic Agents, PhytogenicCyclohexane MonoterpenesDrug Screening Assays, AntitumorEvodiaFruitHL-60 CellsHumansIndolesMolecular StructureMonoterpenesNuclear Magnetic Resonance, BiomolecularQuinazolinesSitosterols

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21985129

Citation

Huang, Xin, et al. "Indoloquinazoline Alkaloids From Euodia Rutaecarpa and Their Cytotoxic Activities." Journal of Asian Natural Products Research, vol. 13, no. 11, 2011, pp. 977-83.
Huang X, Zhang YB, Yang XW. Indoloquinazoline alkaloids from Euodia rutaecarpa and their cytotoxic activities. J Asian Nat Prod Res. 2011;13(11):977-83.
Huang, X., Zhang, Y. B., & Yang, X. W. (2011). Indoloquinazoline alkaloids from Euodia rutaecarpa and their cytotoxic activities. Journal of Asian Natural Products Research, 13(11), 977-83. https://doi.org/10.1080/10286020.2011.602015
Huang X, Zhang YB, Yang XW. Indoloquinazoline Alkaloids From Euodia Rutaecarpa and Their Cytotoxic Activities. J Asian Nat Prod Res. 2011;13(11):977-83. PubMed PMID: 21985129.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Indoloquinazoline alkaloids from Euodia rutaecarpa and their cytotoxic activities. AU - Huang,Xin, AU - Zhang,You-Bo, AU - Yang,Xiu-Wei, Y1 - 2011/10/10/ PY - 2011/10/12/entrez PY - 2011/10/12/pubmed PY - 2012/1/21/medline SP - 977 EP - 83 JF - Journal of Asian natural products research JO - J Asian Nat Prod Res VL - 13 IS - 11 N2 - Nine indoloquinazoline alkaloids (1-9) were isolated from the dried and nearly ripe fruits of Euodia rutaecarpa (Juss.) Benth. (Euodiae Fructus), along with limonin and β-sitosterol. Their structures were elucidated on the basis of their spectroscopic data. Among them, compounds 1 and 2 were new compounds and characterized as (7R,8S)-7-hydroxy-8-methoxy-rutaecarpine and (7R,8S)-7-hydroxy-8-ethoxy-rutaecarpine, respectively, and 1-hydroxy-rutaecarpine (3) and (7R,8S)-7,8-dihydroxy-rutaecarpine (4) were isolated from Euodiae Fructus for the first time. The nine indoloquinazoline alkaloids were evaluated for their cytotoxic activities against human promyelocytic leukemia HL-60 cells and human gastric carcinoma N-87 cells. SN - 1477-2213 UR - https://www.unboundmedicine.com/medline/citation/21985129/Indoloquinazoline_alkaloids_from_Euodia_rutaecarpa_and_their_cytotoxic_activities_ L2 - https://www.tandfonline.com/doi/full/10.1080/10286020.2011.602015 DB - PRIME DP - Unbound Medicine ER -